Potential for cytologic breast fluid analysis in breast disease

1986 ◽  
Vol 8 (1) ◽  
pp. 21-23 ◽  
Author(s):  
Shahnaz Hashmi Dairkee ◽  
Adeline J. Hackett
Keyword(s):  
Breast Disease ◽  
Fluid Analysis ◽  
Breast Fluid

Nipple aspirates of breast fluid and the epidemiology of breast disease

Cancer ◽  
1985 ◽  
Vol 56 (6) ◽  
pp. 1473-1478 ◽  
Author(s):  
Ernst L. Wynder ◽  
Heli Lahti ◽  
Kristiina Laakso ◽  
Shu-Lin Cheng ◽  
Susan Debevoise ◽  
...  
Keyword(s):  
Breast Disease ◽  
Breast Fluid ◽  
Nipple Aspirates

Prospective multicenter trial to determine the feasibility of collection and predictive ability of breast fluid analysis in postmenopausal women receiving SERMs

The Breast ◽  
2007 ◽  
Vol 16 (5) ◽  
pp. 489-494 ◽  
Author(s):  
Edward R. Sauter ◽  
Patricia A. Ganz ◽  
Hormoz Ehya ◽  
John E. Hewett ◽  
Lisa Schlatter ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Predictive Ability ◽  
Multicenter Trial ◽  
Fluid Analysis ◽  
Breast Fluid ◽  
Prospective Multicenter Trial

Cytologic Evaluation of Breast Fluid in the Detection of Breast Disease 2

1977 ◽  
Vol 59 (4) ◽  
pp. 1073-1080 ◽  
Author(s):  
Otto W. Sartorius ◽  
Helene S. Smith ◽  
Peter Morris ◽  
Doris Benedict ◽  
Lawrence Friesen
Keyword(s):  
Breast Disease ◽  
Breast Fluid

Oestrogens and other biochemical and cytological components in nipple aspirates of breast fluid: relationship to risk factors for breast disease

1989 ◽  
Vol 95 ◽  
pp. 169-181
Author(s):  
Nicholas L. Petrakis
Keyword(s):  
Serum Levels ◽  
Breast Disease ◽  
Breast Diseases ◽  
Published Data ◽  
Factors Affecting ◽  
Biochemical Constituents ◽  
Nipple Aspiration ◽  
Nulliparous Women ◽  
Breast Fluid ◽  
High Concentrations

SynopsisThe breast of the nonpregnant woman secretes, retains or reabsorbs a variety of endogenous and exogenous biochemical substances of potential physiological and clinical significance. Among these substances are steroid hormones, prolactin, growth hormones, and peptide growth factors. Because the concentrations of these hormones secreted into the breast ducts are often significantly higher than the concentrations in serum, the breast epithelium is commonly exposed to very high concentrations of steroid and other hormones which may play a role in the aetiology and pathogenesis of breast disease.This paper presents a brief review of published data on the cytological and biochemical constituents of breast fluid obtained by nipple aspiration and data on factors affecting oestradiol and oestrone concentrations in breast fluid. Concentrations of oestradiol and oestrone in nipple aspirate fluid are much higher than in serum, not correlated with serum levels, much lower in women who recently have given birth or breast-fed their infants, not related to day in menstrual cycle, and higher in women with biopsied benign breast disease compared with nulliparous women without breast disease.Further studies of the interrelationships of hormones, other biochemical constituents and the cytopathology of breast fluid may provide new insights into the pathophysiology and aetiology of breast diseases.

Surface ultrastructure of danazol treated rat endometrium: A SEM study

1983 ◽  
Vol 41 ◽  
pp. 556-557
Author(s):  
R.P. Apkarian ◽  
J.S. Sanfilippo
Keyword(s):  
Cross Sections ◽  
Reproductive Tract ◽  
Preliminary Investigation ◽  
Breast Disease ◽  
Distal Segment ◽  
Uterine Horn ◽  
Female Reproductive Tract ◽  
Ultrastructural Changes ◽  
Cycle Phase ◽  
Sprague Dawley

The synthetic androgen danazol, is an isoxazol derivative of ethisterone. It is utilized in the treatment of endometriosis, fibrocystic breast disease, and has a potential use as a contraceptive. A study was designed to evaluate the ultrastructural changes associated with danazol therapy in a rat model. The preliminary investigation of the distal segment of the rat uterine horn was undertaken as part of a larger study intended to elucidate the effects of danazol on the female reproductive tract.Cross-sections (2-3 mm in length) of the distal segment of the uterine horn from sixteen Sprague-Dawley rats were prepared for SEM. Ten rats in estrus served as controls and six danazol treated rats were noted to have alterations of the estrus cycle i.e. a lag in cycle phase or noncycling patterns. Specimens were fixed in 3% glutaraldehyde in 0.05M phosphate buffer containing CaCl2 at pH 7.0-7.4 and chilled to 4°C. After a brief wash in distilled water, specimens were passed through a graded series of ethanol, critical point dryed in CO2 from absolute ethanol, and coated with 6nm Au. Observations were made with an IS1-40 SEM operated at 15kV.

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