The multifunctional role of transforming growth factor (TGF)-ßs on mammary epithelial cell biology

1996 ◽  
Vol 38 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Carlos L. Arteaga ◽  
Teresa C. Dugger ◽  
Stephen D. Hurd
Keyword(s):  
Growth Factor ◽  
Epithelial Cell ◽  
Cell Biology ◽  
Mammary Epithelial Cell ◽  
Transforming Growth Factor ◽  
Mammary Epithelial

scholarly journals Accelerated Mammary Tumor Development in Mutant Polyomavirus Middle T Transgenic Mice Expressing Elevated Levels of Either the Shc or Grb2 Adapter Protein

1999 ◽  
Vol 19 (12) ◽  
pp. 8169-8179 ◽  
Author(s):  
Michael J. Rauh ◽  
Valerie Blackmore ◽  
Eran R. Andrechek ◽  
Christopher G. Tortorice ◽  
Roger Daly ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Mammary Tumorigenesis ◽  
Growth Factor Receptor ◽  
Mammary Epithelium ◽  
Mammary Epithelial ◽  
Adapter Proteins ◽  
Adapter Protein

ABSTRACT The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial development and tumorigenesis, we have generated transgenic mice which individually express the Grb2 and Shc proteins in the mammary epithelium. Although mammary epithelial cell-specific expression of Grb2 or Shc accelerated ductal morphogenesis, mammary tumors were rarely observed in these strains. To explore the potential role of these adapter proteins in mammary tumorigenesis, mice coexpressing either Shc or Grb2 and a mutant form of polyomavirus middle T (PyV mT) antigen in the mammary epithelium were generated. Coexpression of either Shc or Grb2 with the mutant PyV mT antigen resulted in a dramatic acceleration of mammary tumorigenesis compared to parental mutant PyV mT strain. The increased rate of tumor formation observed in these mice was correlated with activation of the epidermal growth factor receptor family and mitogen-activated protein kinase pathway. These observations suggest that elevated levels of the Grb2 or Shc adapter protein can accelerate mammary tumor progression by sensitizing the mammary epithelial cell to growth factor receptor signaling.

Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development

2001 ◽  
Vol 188 (1) ◽  
pp. 75-88 ◽  
Author(s):  
Ping-Ping H. Lee ◽  
Jiuan-Jiuan Hwang ◽  
Lawrence Mead ◽  
Margot M. Ip
Keyword(s):  
Epithelial Cell ◽  
Matrix Metalloproteinases ◽  
Mammary Epithelial Cell ◽  
Functional Role ◽  
Cell Development ◽  
Mammary Epithelial
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