Progressive axonopathy: An inherited neuropathy of boxer dogs. 4. myelin sheath and Schwann cell changes in the nerve roots

1987 ◽  
Vol 16 (2) ◽  
pp. 145-153 ◽  
Author(s):  
I. R. Griffiths ◽  
M. C. McCulloch ◽  
S. Abrahams
Keyword(s):  
Schwann Cell ◽  
Myelin Sheath ◽  
Nerve Roots ◽  
Inherited Neuropathy ◽  
Cell Changes ◽  
Boxer Dogs

Formation of Lamellar Bodies in Schwann Cell Cytoplasm Induced by Alcohol Injury

1972 ◽  
Vol 30 ◽  
pp. 96-97
Author(s):  
C. N. Sun ◽  
H. J. White ◽  
S. Flanigan
Keyword(s):  
Schwann Cell ◽  
Myelin Sheath ◽  
Intrathecal Injection ◽  
Ethanol Treatment ◽  
Lamellar Bodies ◽  
Cell Cytoplasm ◽  
Nerve Roots ◽  
Alcohol Injection ◽  
Complete Destruction ◽  
Alcohol Injury

The presence of lamellar bodies in the Schwann cell has been encountered in several occasions. This presentation deals with lamellar bodies which occur in the Schwann cell of patients treated with 0.8 cc absolute ethanol intrathecal injection for relief of pain. Biopsies of nerve roots in the region of injection were taken from patients, 2 days and 5 days after ethanol treatment. Two days after alcohol injection, the myelin sheath of the axon in the Schwann cells was disrupted; in many cases, a complete destruction of the myelin system was seen (Fig. 1). By the 5th day after treatment, apparently less destruction was seen and we are led to assume that the damaged axons recovered through a process of remyelinization, although focal degeneration of the myelin sheath and lamellar bodies still remained.

Progressive axonopathy: An inherited neuropathy of Boxer dogs

1986 ◽  
Vol 75 (1) ◽  
pp. 69-88 ◽  
Author(s):  
I.R. Griffiths ◽  
E. Kyriakides ◽  
J. Scott
Keyword(s):  
Inherited Neuropathy ◽  
Boxer Dogs

LIPID–PROTEIN COMPLEXES IN MEMBRANES OF NERVOUS TISSUE

1962 ◽  
Vol 40 (1) ◽  
pp. 1261-1271
Author(s):  
L. S. Wolfe
Keyword(s):  
Nervous System ◽  
Sialic Acid ◽  
Schwann Cell ◽  
Myelin Sheath ◽  
Nervous Tissue ◽  
Chemical Structure ◽  
Grey Matter ◽  
Protein Complexes ◽  
Functional Importance ◽  
Acetylneuraminic Acid

Recent investigations have demonstrated that cellular and intracellular membranes within the nervous system contain complex associations of lipids, proteins, and carbohydrates. The myelin sheath contains such complexes derived from the Schwann cell or satellite cell membranes. Similar complexes are found in membranes from grey matter together with less familiar associations between lipids and carbohydrates. Gangliosides are a group of acidic glycolipids which contain among other sugars the sialic acid, N-acetylneuraminic acid. The present state of knowledge on the chemical structure, metabolism, and functional importance of these complex macromolecules is discussed.

Development of the axon membrane during differentiation of myelinated fibres in spinal nerve roots

1980 ◽  
Vol 209 (1176) ◽  
pp. 441-446 ◽  
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Spinal Nerve ◽  
Spinal Nerve Roots ◽  
Nerve Roots ◽  
Axon Membrane ◽  
Nodal Membrane ◽  
Spinal Roots ◽  
Myelinated Fibres

Previous studies by a number of workers have shown that the axon membrane in normal mature myelinated fibres is highly differentiated, with the nodal axolemma exhibiting characteristics different to those of the internodal axolemma. However, the development of this axolemmal heterogeneity has not been previously explored. In the present study we used cytochemical methods to examine the development of nodal axolemma during the differentiation of myelinated fibres in rat spinal roots. The staining properties characteristic of normal nodal membrane appear in the axon, at gaps between Schwann cells, before the develop­ment of mature compact myelin or well defined paranodal axon-Schwann cell specializations close to the region of nodal axolemmal differentiation. These results are consistent with the hypothesis that the axon membrane differentiates into nodal and internodal regions before, or early in the process of, myelination, and suggest that the differentiation of the axon membrane may provide a signal demarcating the region to be covered by the myelin-forming cell.

scholarly journals A TIME-SEQUENCE AUTORADIOGRAPHIC STUDY OF THE IN VIVO INCORPORATION OF [1, 2-3H]CHOLESTEROL INTO PERIPHERAL NERVE MYELIN

1973 ◽  
Vol 58 (1) ◽  
pp. 42-53 ◽  
Author(s):  
Frank A. Rawlins
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Myelin Sheath ◽  
Central Zone ◽  
Autoradiographic Study ◽  
Nerve Fibers ◽  
Time Sequence ◽  
Time Interval ◽  
Electron Microscope Autoradiography

A time-sequence study of the incorporation and distribution of cholesterol in peripheral nerve myelin was carried out by electron microscope autoradiography. [1,2-3H]Cholesterol was injected into 10-day old mice and the sciatic nerves were dissected out at 10, 20, 40, 60, 90, 120, and 180 min after the injection. 20 min after injection the higher densities of grains due to the presence of [3H]cholesterol were confined to the outer and inner edges of the myelin sheath. Practically no cholesterol was detected in the midzone of the myelin sheath. 1 ½ h after injection, cholesterol showed a wider distribution within the myelin sheath, the higher densities of grains occurring over the two peripheral myelin bands, each approximately 3,100 Å wide. Cholesterol was also present in the center of the myelin sheath but to a considerably lesser extent. 3 h after injection cholesterol appeared homogeneously distributed within the myelin sheath. Schwann cell and axon compartments were also labeled at each time interval studied beginning 20 min postinjection. These observations indicate that preformed cholesterol enters myelin first and almost simultaneously through the inner and outer edges of the sheath; only after 90 min does the density of labeled cholesterol in the central zone of myelin reach the same density as that in the outer and inner zones. These findings suggest that cholesterol used by the nerve fibers in the formation and maintenance of the myelin sheath enters the lamellae from the Schwann cell cytoplasm and from the axon. The possibility of a bidirectional movement of molecules, i.e. from the Schwann cell to the axon and from the axon to the Schwann cell through the myelin sheath, is noted. The results are discussed in the light of recent observations on the exchange, reutilization, and transaxonal movement of cholesterol.

Schwann cell changes and demyelination in chronic galactose neuropathy

1983 ◽  
Vol 6 (3) ◽  
pp. 218-227 ◽  
Author(s):  
H. C. Powell ◽  
R. R. Myers
Keyword(s):  
Schwann Cell ◽  
Cell Changes
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