Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in Brown-Norway rats

1995 ◽  
Vol 44 (2) ◽  
pp. 83-86 ◽  
Author(s):  
W. Elwood ◽  
J. Sun ◽  
P. J. Barnes ◽  
M. A. Giembycz ◽  
K. F. Chung
Keyword(s):  
Phosphodiesterase Inhibitors ◽  
Brown Norway ◽  
Type Iii ◽  
Lung Eosinophilia ◽  
Norway Rats

scholarly journals Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats

2008 ◽  
Vol 9 (3) ◽  
Author(s):  
Norbert Fülöp ◽  
Wenguang Feng ◽  
Dongqi Xing ◽  
Kai He ◽  
László G. Nőt ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Age-related declines in thirst and salt appetite responses in male Fischer 344×Brown Norway rats

2014 ◽  
Vol 135 ◽  
pp. 180-188 ◽  
Author(s):  
Robert L. Thunhorst ◽  
Terry Beltz ◽  
Alan Kim Johnson
Keyword(s):  
Brown Norway ◽  
Salt Appetite ◽  
Fischer 344 ◽  
Age Related ◽  
Norway Rats

Effect of interleukin-1β on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats

1994 ◽  
Vol 93 (2) ◽  
pp. 464-469 ◽  
Author(s):  
Hideo Tsukagoshi ◽  
Tatsuo Sakamoto ◽  
Wenbing Xu ◽  
Peter J. Barnes ◽  
K.Fan Chung
Keyword(s):  
Airway Hyperresponsiveness ◽  
Interleukin 1Β ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Enhanced Antigen-Specific Delayed-Type Hypersensitivity and Immunoglobulin G2b Responses after Oral Administration of ViableLactobacillus casei YIT9029 in Wistar and Brown Norway Rats

2001 ◽  
Vol 8 (4) ◽  
pp. 762-767 ◽  
Author(s):  
R. de Waard ◽  
J. Garssen ◽  
J. Snel ◽  
G. C. A. M. Bokken ◽  
T. Sako ◽  
...  
Keyword(s):  
Trichinella Spiralis ◽  
Active Role ◽  
Lymphoid Organ ◽  
Delayed Type Hypersensitivity ◽  
Brown Norway ◽  
Infection Model ◽  
Cell Mediated Immunity ◽  
Th1 Cell ◽  
Inflammatory Reactions ◽  
Norway Rats

ABSTRACT In this study, the effects of orally administered viableLactobacillus casei Shirota strain YIT9029 on the immunity parameters of Wistar and Brown Norway rats were examined. For this purpose, we used the Trichinella spiralis host resistance model. Two weeks before and during T. spiralisinfection, rats were fed 109 viable L. casei bacteria 5 days per week. The T. spiralis-specific delayed-type hypersensitivity (DTH) response was significantly enhanced in both Wistar and Brown Norway rats given L. casei. In both rat strains fedL. casei, serum T. spiralis-specific immunoglobulin G2b (IgG2b) concentrations were also significantly increased. In the model, no significant effects ofL. casei on larval counts or inflammatory reactions in the tongue musculature, body weights, or lymphoid organ weights were observed. Serum specific antibody responses, other than IgG2b, were not changed by feeding of L. casei. In contrast toL. casei, it was shown that orally administeredBifidobacterium breve or Bifidobacterium bifidum had no influence on the measured infection and immunity indices in the rat infection model. Since the rat DTH response is considered to be a manifestation of Th1 cell-mediated immunity and the IgG2b isotype has been associated with Th1 activity, it was concluded that Th1 cells could play an active role in the immunomodulatory effects of orally administered L. casei. Furthermore, our data do not indicate that the effect of oral supplementation withL. casei is dependent on the genetic background of the host.

Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats

1996 ◽  
Vol 315 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Marian T. Namovic ◽  
Robin E. Walsh ◽  
Carole Goodfellow ◽  
Richard R. Harris ◽  
George W. Carter ◽  
...  
Keyword(s):  
Brown Norway ◽  
Pharmacological Modulation ◽  
Norway Rats

Supplementing docosahexaenoic acid along with arachidonic acid during weaning period improves immune response in neonatal Brown Norway rats

2021 ◽  
Author(s):  
Dhruvesh Patel ◽  
Marnie Newell ◽  
Susan Goruk ◽  
Sue Tsai ◽  
Caroline Richard ◽  
...  
Keyword(s):  
Immune Response ◽  
Arachidonic Acid ◽  
Docosahexaenoic Acid ◽  
Brown Norway ◽  
Norway Rats

Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats

1989 ◽  
Vol 66 (2) ◽  
pp. 606-612 ◽  
Author(s):  
S. Bellofiore ◽  
D. H. Eidelman ◽  
P. T. Macklem ◽  
J. G. Martin
Keyword(s):  
Lung Volume ◽  
Brown Norway ◽  
Pulmonary Mechanics ◽  
Maximum Increase ◽  
Before And After ◽  
Airway Response ◽  
Residual Capacity ◽  
Airway Responses ◽  
Norway Rats ◽  
Concentration Response Curve

We examined the effects of elastase-induced emphysema on lung volumes, pulmonary mechanics, and airway responses to inhaled methacholine (MCh) of nine male Brown Norway rats. Measurements were made before and weekly for 4 wk after elastase in five rats. In four rats measurements were made before and at 3 wk after elastase; in these same animals the effects of changes in end-expiratory lung volume on the airway responses to MCh were evaluated before and after elastase. Airway responses were determined from peak pulmonary resistance (RL) calculated after 30-s aerosolizations of saline and doubling concentrations of MCh from 1 to 64 mg/ml. Porcine pancreatic elastase (1 IU/g) was administered intratracheally. Before elastase RL rose from 0.20 +/- 0.02 cmH2O.ml-1.s (mean +/- SE; n = 9) to 0.57 +/- 0.06 after MCh (64 mg/ml). A plateau was observed in the concentration-response curve. Static compliance and the maximum increase in RL (delta RL64) were significantly correlated (r = 0.799, P less than 0.01). Three weeks after elastase the maximal airway response to MCh was enhanced and no plateau was observed; delta RL64 was 0.78 +/- 0.07 cmH2O.ml-1.s, significantly higher than control delta RL64 (0.36 +/- 0.7, P less than 0.05). Before elastase, increase of end-expiratory lung volume to functional residual capacity + 1.56 ml (+/- 0.08 ml) significantly reduced RL at 64 mg MCh/ml from 0.62 +/- 0.05 cmH2O.ml-1.s to 0.50 +/- 0.03, P less than 0.05.(ABSTRACT TRUNCATED AT 250 WORDS)

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