Lymph node metastasis and cell movement: ultrastructural studies on the rat 13762 mammary carcinoma and Walker carcinoma

1985 ◽  
Vol 3 (2) ◽  
pp. 125-139 ◽  
Author(s):  
I. Carr ◽  
M. Levy ◽  
K. Orr ◽  
J. Bruni
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mammary Carcinoma ◽  
Cell Movement ◽  
Ultrastructural Studies ◽  
Node Metastasis ◽  
Walker Carcinoma

scholarly journals Tumor-associated macrophage is correlated with survival and SOCS protein expression in canine mammary carcinoma

2018 ◽  
Vol 38 (10) ◽  
pp. 1972-1980
Author(s):  
Carlos H.C. Vieira-Filho ◽  
Stella M. Barrouin-Melo ◽  
Karine A. Damasceno ◽  
Márcio S.S. Araújo ◽  
Natalie F. Borges ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mammary Carcinoma ◽  
Inflammatory Infiltrate ◽  
Histological Grade ◽  
Survival Rates ◽  
Clinical Staging ◽  
Clinicopathological Parameters ◽  
Node Metastasis ◽  
Socs3 Expression

ABSTRACT: The inflammatory infiltrate in the tumor microenvironment, particularly in mammary tumors, has aroused great interest in oncology, to play different roles in the progression or tumor regression dependent on the types and cell subsets involved. The present study aimed to evaluate (1) the occurrence and intensity of macrophage infiltration in the mammary carcinoma microenvironment, (2) the expression of SOCS1 and SOCS3 proteins in tumor associated macrophages, (3) any association between these parameters and tumor development, as well as survival rates in female dogs. Twenty-two female dogs diagnosed as carcinoma arising in a mixed tumor (CMT) by histopathology were divided into two groups following mastectomy: dogs without metastasis (CMT(-)=11) and those with metastasis (CMT(+)=11). The following parameters were analyzed: tumor size, lymph node metastasis, clinical stage, histological grade, distribution and intensity of inflammatory infiltrate, tumor macrophage quantification by immunohistochemical analysis of SOCS1 and SOCS3 expression, and immunophenotyping of peripheral blood leukocytes by flow cytometry. Dogs with the higher proportions of macrophages in the inflammatory infiltrate (≥400/tumor) also had higher survival rates in comparison with dogs with less macrophages. Immunostaining revealed higher proportions of SOCS3-positive macrophages in dogs without lymph node metastasis, while SOCS1-positive macrophages were predominant in dogs with metastasis (p<0.05). Multivariate analysis found associations between survival rate and clinical staging (p=0.025), histological grade (p=0.007), and the expression of MHC-CI in circulating monocytes (p=0.018). Higher SOCS3 expression in activated macrophages within the inflammatory infiltrate were considered indicative of an antitumor immune response, improved clinicopathological parameters and longer survival, whereas SOCS1-related activation was associated with tumor progression, metastasis development and reduced survival in female dogs with mammary carcinomas.

scholarly journals Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

2011 ◽  
Vol 121 (5) ◽  
pp. 2000-2012 ◽  
Author(s):  
Dontscho Kerjaschki ◽  
Zsuzsanna Bago-Horvath ◽  
Margaretha Rudas ◽  
Veronika Sexl ◽  
Christine Schneckenleithner ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mammary Carcinoma ◽  
Lymphatic Vessels ◽  
Human Mammary Carcinoma ◽  
Node Metastasis

Desmopressin inhibits lung and lymph node metastasis in a mouse mammary carcinoma model of surgical manipulation

2002 ◽  
Vol 81 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Santiago Giron ◽  
Agueda M. Tejera ◽  
Giselle V. Ripoll ◽  
Daniel E. Gomez ◽  
Daniel F. Alonso
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mammary Carcinoma ◽  
Mouse Mammary Carcinoma ◽  
Node Metastasis ◽  
Surgical Manipulation

scholarly journals Lymphangiogenesis and Axillary Lymph Node Metastases Correlated with VEGF-C Expression in Two Immunocompetent Mouse Mammary Carcinoma Models

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Yuko Ito ◽  
Masa-Aki Shibata ◽  
Nabil Eid ◽  
Junji Morimoto ◽  
Yoshinori Otsuki
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Line ◽  
Mouse Models ◽  
Mammary Carcinoma ◽  
Axillary Lymph Node ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Mouse Mammary Carcinoma ◽  
Node Metastasis

Lymphangiogenesis and the expression of vascular endothelial cell growth factor C (VEGF-C) in tumors have been considered to be causally promoting lymphatic metastasis. There are only a few studies on lymphatic metastasis in immunocompetent allograft mouse models. To study the relationship between VEGF-C-mediated lymphangiogenesis and axillary lymph node metastasis, we used two mouse mammary carcinoma cell lines; the BJMC338 has a low metastatic propensity, whereas the BJMC3879 has a high metastatic propensity although it originated from the former cell line. Each cell line was injected separately into two groups of female BALB/cmice creatingin vivomammary cancer models. The expression level of VEGF-C in BJMC3879 was higher than BJMC338. As the parent cell line, BJMC3879-derived tumors showed higher expression of VEGF-C compared to BJMC338-derived tumors. This higher expression of VEGF-C in BJMC3879-derived tumors was associated with marked increase in infiltrating macrophages and enhanced expression of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) reflecting increased tumoral lymphatic density and subsequent induction of axillary lymph node metastasis. Our mouse mammary carcinoma models are allotransplanted tumors showing the same axillary lymph node metastatic spectrum as human breast cancers. Therefore, our mouse models are ideal for exploring the various molecular mechanisms of cancer metastasis.

Lymph Node Metastasis in the Biliary Tract Carcinoma: CT Evaluation

1994 ◽  
Vol 31 (1) ◽  
pp. 119
Author(s):  
Young Soo Do ◽  
Byung Hee Lee ◽  
Kie Hwan Kim ◽  
Soo Yil Chin ◽  
Ah Ra Lee
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Biliary Tract ◽  
Biliary Tract Carcinoma ◽  
Node Metastasis ◽  
Ct Evaluation
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