Killer cells induced by stimulation with allogeneic tumor cells and subsequent culture with recombinant interleukin-2

1991 ◽  
Vol 33 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Tadahiro Fukiage ◽  
Hiroki Murakami ◽  
Masao Eura ◽  
Tsutomu Ikawa ◽  
Takeru Ishikawa
Keyword(s):  
Tumor Cells ◽  
Interleukin 2 ◽  
Killer Cells ◽  
Allogeneic Tumor ◽  
Recombinant Interleukin 2

Continuous infusion of recombinant interleukin-2 and lymphokine-activated killer cells in refractory malignancies

1989 ◽  
Vol 17 (5-6) ◽  
pp. 455-458 ◽  
Author(s):  
Neal P. Christiansen ◽  
B. J. Kennedy ◽  
Augusto C. Ochoa ◽  
Keith M. Skubitz ◽  
Fritz H. Bach
Keyword(s):  
Continuous Infusion ◽  
Interleukin 2 ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Recombinant Interleukin 2

Generation of tumor-specific cytotoxic T lymphocytesin vivo by combined treatment with inactivated tumor cells and recombinant interleukin-2

1994 ◽  
Vol 38 (5) ◽  
pp. 332-338
Author(s):  
Mamoru Harada ◽  
Goro Matsuzaki ◽  
Yoshihiro Shinomiya ◽  
Shin Kurosawa ◽  
Osamu Ito ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Combined Treatment ◽  
Interleukin 2 ◽  
Recombinant Interleukin 2

Interstitial Nephritis in a Patient Receiving Adoptive Immunotherapy with Recombinant Interleukin-2 and Lymphokine-Activated Killer Cells

1991 ◽  
Vol 11 (6) ◽  
pp. 489-492 ◽  
Author(s):  
Donald A. Feinfeld ◽  
Vivette D’Agati ◽  
Janice P. Dutcher ◽  
Steven B. Werfel ◽  
Robert I. Lynn ◽  
...  
Keyword(s):  
Interstitial Nephritis ◽  
Adoptive Immunotherapy ◽  
Interleukin 2 ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Recombinant Interleukin 2

Specific cytotoxic activity of T lymphocyte clones derived from a patient with gliosarcoma

1988 ◽  
Vol 69 (5) ◽  
pp. 751-759 ◽  
Author(s):  
Shin-Ichi Miyatake ◽  
Haruhiko Kikuchi ◽  
Kohichi Iwasaki ◽  
Junkoh Yamashita ◽  
Yuzirou Namba ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Cytotoxic Activity ◽  
Tumor Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Interleukin 2 ◽  
Target Cells ◽  
Autologous Tumor ◽  
Lymphokine Activated Killer Cells ◽  
Recombinant Interleukin 2

✓ Eleven lymphocyte clones were established from the peripheral blood lymphocytes of a patient with gliosarcoma by means of autologous tumor stimulation and the limiting-dilution technique with recombinant interleukin-2. Ten of the 11 clones were cytotoxic against the autologous tumor cell line GI-1. Seven of the 10 clones were also cytotoxic against allogeneic brain-tumor lines and HeLa cells, one clone was cytotoxic against several target cells, and two clones were specifically cytotoxic against GI-1 and allogeneic brain-tumor cells. One of the 11 clones was not cytotoxic against any target cells tested. Lymphokine-activated killer cells induced by recombinant interleukin-2 alone exhibited cytotoxic activity against all target tumor cells tested. Surface phenotypic analysis revealed that all lymphocyte clones expressed CD3 antigen, some expressed CD4 antigen, and others expressed CD8 antigen. These clones seemed to be antigen-specific cytotoxic T lymphocyte clones. Analysis with these antigen-specific cytotoxic T lymphocyte clones may be useful in the elucidation of tumor-specific or tumor-associated antigens on autologous tumor cells.

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