Extraneuronal uptake of noradrenaline in human tissue (uptake2)

1995 ◽  
Vol 10 (3) ◽  
pp. 151-153 ◽  
Author(s):  
Jörg Babin-Ebell ◽  
Martin Gliese
Keyword(s):  
Human Tissue ◽  
Extraneuronal Uptake ◽  
Uptake Of Noradrenaline

Effects of corticoadrenal extract on the neuronal and extraneuronal uptake of noradrenaline in the isolated rabbit heart

1985 ◽  
Vol 72 (2) ◽  
pp. 94-95
Author(s):  
Pham Huu Chanh ◽  
R. Kaiser ◽  
R. Chahine ◽  
K. Abou Khalil ◽  
M. Abou-Assaly ◽  
...  
Keyword(s):  
Rabbit Heart ◽  
Extraneuronal Uptake ◽  
Isolated Rabbit Heart ◽  
Uptake Of Noradrenaline

Extraneuronal uptake of noradrenaline in rabbit dental pulp: evidence of identity with uptake

1992 ◽  
Vol 346 (2) ◽  
pp. 166-172 ◽  
Author(s):  
V. Marino ◽  
I. S. de la Laude ◽  
D. A. S. Parker ◽  
J. Dally ◽  
S. Wing
Keyword(s):  
Dental Pulp ◽  
Extraneuronal Uptake ◽  
Uptake Of Noradrenaline ◽  
Rabbit Dental Pulp

Inhibition of neuronal noradrenaline uptake by angiotensin II in the rat mesentery

1979 ◽  
Vol 57 (12) ◽  
pp. 1443-1447 ◽  
Author(s):  
Edwin K. Jackson ◽  
William B. Campbell
Keyword(s):  
Angiotensin Ii ◽  
Extraneuronal Uptake ◽  
Neuronal Uptake ◽  
Appreciable Effect ◽  
Noradrenaline Uptake ◽  
Similar Extent ◽  
Rat Mesentery ◽  
Uptake Of Noradrenaline ◽  
6 Hydroxydopamine ◽  
Uptake Blockers

In the isolated perfused rat mesentery, angiotensin II (3 × 10−9 M) in subpressor doses enhanced the vasoconstrictor responses to noradrenaline by 9.6 ± 1.4 mmHg. However, in mesenteries obtained from rats chemically sympathectomized with 6-hydroxydopamine, angiotensin II was without effect. Treatment of mesenteries with the noradrenaline neuronal uptake blockers desmethylimipramine (10−10 M), protriptyline (10−10 M), or cocaine (10−6 M) potentiated responses to noradrenaline by 3.8 ± 0.84, 3.7 ± 0.67, and 5.5 ± 0.26 mmHg, respectively. Angiotensin II alone or in combination with either desmethylimipramine, protriptyline, or cocaine potentiated the noradrenaline responses to a similar extent. On the other hand, corticosterone (1.5 × 10−6 M), an extraneuronal uptake blocker, enhanced noradrenaline responses by 4.3 ± 1.4 mmHg, and this enhancement was additive with the potentiation produced by cocaine and (or) angiotensin II. We conclude that angiotensin II in subpressor doses acts presynaptically to block selectively the neuronal uptake of noradrenaline without any appreciable effect on extraneuronal uptake.

Neuronal and Extraneuronal Uptake of 3H-Norepinephrine in the Heart of the Active Bat: An Electron Microscopic Radioautographic Study

1973 ◽  
Vol 31 ◽  
pp. 522-523
Author(s):  
Martin Hagopian ◽  
Michael D. Gershon ◽  
Eladio A. Nunez
Keyword(s):  
Smooth Muscle ◽  
Monoamine Oxidase ◽  
Vascular Smooth Muscle ◽  
Cardiac Muscle ◽  
Maximum Rate ◽  
External Medium ◽  
Extraneuronal Uptake ◽  
Electron Microscopic ◽  
Cardiac Tissues ◽  
High Affinity

The ability of cardiac tissues to take up norepinephrine from an external medium is well known. Two mechanisms, called Uptake and Uptake respectively by Iversen have been differentiated. Uptake is a high affinity system associated with adrenergic neuronal elements. Uptake is a low affinity system, with a higher maximum rate than that of Uptake. Uptake has been associated with extraneuronal tissues such as cardiac muscle, fibroblasts or vascular smooth muscle. At low perfusion concentrations of norepinephrine most of the amine taken up by Uptake is metabolized. In order to study the localization of sites of norepinephrine storage following its uptake in the active bat heart, tritiated norepinephrine (2.5 mCi; 0.064 mg) was given intravenously to 2 bats. Monoamine oxidase had been inhibited with pheniprazine (10 mg/kg) one hour previously to decrease metabolism of norepinephrine.

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