Influence of antibody protein dose on therapeutic efficacy of radioiodinated antibodies in nude mice bearing GW-39 human tumor

1992 ◽  
Vol 35 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Otto C. Boerman ◽  
Robert M. Sharkey ◽  
George Y. Wong ◽  
Rosalyn D. Blumenthal ◽  
Rosarito L. Aninipot ◽  
...  
Keyword(s):  
Nude Mice ◽  
Therapeutic Efficacy ◽  
Human Tumor

scholarly journals Epigallocatechin-3-gallate-induced vascular normalization in A549-cell xenograft-bearing nude mice: therapeutic efficacy in combination with chemotherapy

2019 ◽  
Vol Volume 11 ◽  
pp. 2425-2439 ◽  
Author(s):  
Pengbo Deng ◽  
ChengPing Hu ◽  
Zeng Xiong ◽  
Yuanyuan Li ◽  
Juan Jiang ◽  
...  
Keyword(s):  
Nude Mice ◽  
A549 Cell ◽  
Therapeutic Efficacy ◽  
Vascular Normalization

Hypothalamic appetite-regulating neuropeptide mRNA levels in cachectic nude mice bearing human tumor cells

Metabolism ◽  
2001 ◽  
Vol 50 (10) ◽  
pp. 1213-1219 ◽  
Author(s):  
N. Nara-Ashizawa ◽  
T. Tsukada ◽  
K. Maruyama ◽  
Y. Akiyama ◽  
N. Kajimura ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Nude Mice ◽  
Human Tumor ◽  
Mrna Levels ◽  
Human Tumor Cells

Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice

2004 ◽  
Vol 15 (8) ◽  
pp. 773-778 ◽  
Author(s):  
Sabrina Lei ◽  
Pei-Yu Chien ◽  
Saifuddin Sheikh ◽  
Allen Zhang ◽  
Shahid Ali ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Human Tumor ◽  
Scid Mice ◽  
Tumor Models

Nude mice with lacZ transduced human tumor xenografts as an in vivo model for invasion and metastasis

Lung Cancer ◽  
1991 ◽  
Vol 7 ◽  
pp. 30 ◽  
Author(s):  
Mogens Spang-Thomsen ◽  
James A. Zwiebel ◽  
Jørgen Rygaard ◽  
Nils Brünner
Keyword(s):  
Nude Mice ◽  
Human Tumor ◽  
In Vivo Model ◽  
Invasion And Metastasis ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts

scholarly journals Repeated Intraperitoneal -Radioimmunotherapy of Ovarian Cancer in Mice

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Jörgen Elgqvist ◽  
Håkan Andersson ◽  
Holger Jensen ◽  
Helena Kahu ◽  
Sture Lindegren ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Monoclonal Antibody ◽  
Cell Line ◽  
Nude Mice ◽  
Therapeutic Efficacy ◽  
Therapeutic Index ◽  
Repeated Treatment ◽  
Treatment Regimens ◽  
Potential Increase

The aim of this study was to investigate the therapeutic efficacy of -radioimmunotherapy of ovarian cancer in mice using different fractionated treatment regimens. The study was performed using the monoclonal antibody MX35 F labeled with the -particle emitter .Methods. Nude mice were intraperitoneally inoculated with ~ cells of the cell line NIH:OVCAR-3. Four weeks later 6 groups of animals were given F as a single or as a repeated treatment of up to 6 times ( in each group). The fractionated treatments were given every seventh day. Control animals were treated with unlabeled F (). Eight weeks posttreatment the animals were sacrificed and the presence of macro- and microscopic tumors and ascites was determined.Results. The tumor-free fractions (TFFs) of the animals, defined as the fraction of animals with no macro- and microtumors and no ascites, were 0.17, 0.11, 0.39, 0.44, 0.44, and 0.67 when treated with F once or 2, 3, 4, 5, or 6 times, respectively. Repeated treatment 3 times or more resulted in a significantly higher () TFF than compared to treatment once or twice. The presence of ascites decreased from 15 out of 18 animals in the group given only one treatment to zero for the 2 groups given 5 or 6 fractions. Treatment with unlabeled F resulted in a TFF of zero.Conclusion. Weekly repeated intraperitoneal injections of tolerable amounts of activity of F of up to 6 times produced increased therapeutic efficacy without observed toxicity, indicating a potential increase of the therapeutic index.

Role of x-linked immunodeficiency (xid) and NK activity in rejection of human tumor xenotransplants in nude mice

Apmis ◽  
1993 ◽  
Vol 101 (1-6) ◽  
pp. 345-352 ◽  
Author(s):  
KOHJI MARUO ◽  
KAZUO SHIMAMURA ◽  
KYOJI HIOKI ◽  
MAMORU ITOH ◽  
YOSHITO UEYAMA ◽  
...  
Keyword(s):  
Nude Mice ◽  
Human Tumor ◽  
Nk Activity

Adeno-associated virus-mediated anti-DR5 chimeric antibody expression suppresses human tumor growth in nude mice

2011 ◽  
Vol 302 (2) ◽  
pp. 119-127 ◽  
Author(s):  
Fujia Lv ◽  
Yuhe Qiu ◽  
Yaxi Zhang ◽  
Shilian Liu ◽  
Juan Shi ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Nude Mice ◽  
Human Tumor ◽  
Chimeric Antibody ◽  
Adeno Associated Virus ◽  
Antibody Expression
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