Kinetics of hydrogen-deuterium exchange of tryptophan and tryptophan peptides in deutero-trifluoroacetic acid using proton magnetic resonance spectroscopy

1976 ◽  
Vol 12 (2) ◽  
pp. 103-111 ◽  
Author(s):  
Raymond S. Norton ◽  
J. Howard Bradbury
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Trifluoroacetic Acid ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Deuterium Exchange ◽  
Resonance Spectroscopy ◽  
Hydrogen Deuterium Exchange ◽  
Hydrogen Deuterium ◽  
Kinetics Of

Anisotropic effects on proton magnetic resonance frequencies of substituted barbituric acids

1969 ◽  
Vol 47 (5) ◽  
pp. 743-750 ◽  
Author(s):  
George A. Neville ◽  
Denys Cook
Keyword(s):  
Infrared Spectroscopy ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Magnetic Resonance Spectroscopy ◽  
Trifluoroacetic Acid ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Alkyl Substitution ◽  
Resonance Frequencies

Several pharmacologically important barbituric acids were examined by proton magnetic resonance spectroscopy in trifluoroacetic acid, p-dioxane, and dimethyl sulfoxide-d6. The data obtained greatly facilitate identifying and distinguishing barbiturates. Variations in chemical shift with alkyl substitution have been discussed, and the suggestion has been put forward that—the CH3(Et) protons may be a sensitive probe for detecting changes in anisotropy (both ring and C=O) in a series of barbiturates. Evidence for the preferred configuration of C-5 phenyl, ethyl, and isopropyl substituents was obtained. Concentration studies by both proton magnetic resonance and infrared spectroscopy indicate that the barbiturates examined exist predominantly as solvated monomers rather than as dimers or oligomers.

scholarly journals Imaging intelligence with proton magnetic resonance spectroscopy

Intelligence ◽  
2009 ◽  
Vol 37 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Rex E. Jung ◽  
Charles Gasparovic ◽  
Robert S. Chavez ◽  
Arvind Caprihan ◽  
Ranee Barrow ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

Disulfiram Determination by Proton Magnetic Resonance Spectroscopy and by Colorimetry

1973 ◽  
Vol 56 (1) ◽  
pp. 124-127 ◽  
Author(s):  
Eric B Sheinin ◽  
Walter R Benson ◽  
Myron M Smith
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Colorimetric Method ◽  
Drug Substance ◽  
Resonance Spectroscopy ◽  
Pmr Spectroscopy ◽  
Label Claim ◽  
Tablet Excipients

Abstract Disulfiram was determined in disulfiram drug substance and tablets by proton magnetic resonance (PMR) spectroscopy at the 100–480 mg level and by a colorimetric technique involving cuprous iodide at the 50 mg level. The tablet excipients do not interfere in the analysis. The average result for disulfiram in a tablet composite was 100.8±1.4% of label claim by PMR and 100.7±0.4% by the colorimetric method.

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