Evidence of in vivo iodine-induced hyperthyroidism in hyperfunctional autoimmune and autonomous human thyroid tissue xenotransplanted to nude mice

1987 ◽  
Vol 65 (4) ◽  
pp. 197-201 ◽  
Author(s):  
P. -M. Schumm-Draeger ◽  
R. Senekowitsch ◽  
F. -D. Maul ◽  
H. J. C. Wenisch ◽  
C. R. Pickardt ◽  
...  
Keyword(s):  
Nude Mice ◽  
Thyroid Tissue ◽  
Human Thyroid ◽  
Human Thyroid Tissue

Immunologic Effects of Human Peripheral and Intrathyroidal Lymphocytes on Xenotransplanted Human Thyroid Tissue in Athymic Nude Mice

Thyroid ◽  
1999 ◽  
Vol 9 (1) ◽  
pp. 39-46 ◽  
Author(s):  
K. JUNGHEIM ◽  
K.H. USADEL ◽  
G. CASPAR ◽  
P.M. SCHUMM-DRAEGER
Keyword(s):  
Nude Mice ◽  
Thyroid Tissue ◽  
Human Thyroid ◽  
Athymic Nude Mice ◽  
Human Thyroid Tissue

IODOTHYRONINE CONTENT OF HUMAN THYROID ALBUMIN

1976 ◽  
Vol 81 (2) ◽  
pp. 288-297
Author(s):  
Colette Thomas-Morvan
Keyword(s):  
Thyroid Hormones ◽  
Gel Electrophoresis ◽  
Thyroid Tissue ◽  
Iodine Concentration ◽  
Human Thyroid ◽  
Human Thyroid Tissue ◽  
Normal Human ◽  
The Difference ◽  
Radioactive Measurement

ABSTRACT Stable thyroid hormones (T4 and T3)1) have been demonstrated in pure albumin isolated from normal human thyroid tissue iodinated in vivo. Five samples of albumin were separated from other thyroid proteins by acrylamide gel electrophoresis. After pronase hydrolysis, the content of Thyroid hormones was measured chemically (T4 + T3) as well as by competitive radioactive measurement (T4) and radioimmunoassay (T3). The purity of the albumin and validity of these measurements were confirmed by different techniques. The synthesis of thyroid hormones is not therefore a property unique to Tg and may occur in albumin. However the amount of iodothyronines in the albumin (average 0.004 residue per molecule) is much less than that found in Tg (0.5 residue per molecule). In the albumin as in Tg the number of hormone residues per molecule is proportional to the number of atoms of iodine. At an equivalent iodine concentration, the albumin seems capable of forming the thyroid hormones as well as Tg. The difference between these two proteins, in their capacity to synthesize thyroid hormones, seems to depend on their capacity for iodination. This difference of iodination does not seem to be linked with the number of tyrosyl residues, but might be related to the position of these residues.

Vascularization of Normal Human Thyroid Tissue Transplanted to Nude Mice

Pathobiology ◽  
1987 ◽  
Vol 55 (2) ◽  
pp. 104-114
Author(s):  
Johan Mölne ◽  
Erik Jörtsö ◽  
Staffan Smeds ◽  
Lars E. Ericson
Keyword(s):  
Nude Mice ◽  
Thyroid Tissue ◽  
Human Thyroid ◽  
Human Thyroid Tissue ◽  
Normal Human

Iodine-Induced Expression of Immunoglobulin Supergene Family in Normal Human Thyroid Tissue in vivo

1996 ◽  
pp. 32-35
Author(s):  
Petra-Maria Schumm-Draeger ◽  
Hans-Peter Fortmeyer ◽  
Hubertus Johannes Christoph Wenisch ◽  
Claudia Müller ◽  
Klaus Henning Usadel
Keyword(s):  
Thyroid Tissue ◽  
Human Thyroid ◽  
Induced Expression ◽  
Human Thyroid Tissue ◽  
Normal Human ◽  
Immunoglobulin Supergene Family ◽  
Supergene Family

Effect of thyroxine and iodide treatment on xenotransplanted human thyroid tissue endogenously stimulated with TSH

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S48-S49
Author(s):  
P.-M. SCHUMM-DRAEGER ◽  
H.J.C. WENISCH ◽  
F.D. MAUL ◽  
C. TIMM
Keyword(s):  
Thyroid Tissue ◽  
Human Thyroid ◽  
Human Thyroid Tissue
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