Western blot as a seroepidemiologic tool for detecting foci of Mediterranean spotted fever (MSF)

1994 ◽  
Vol 10 (1) ◽  
pp. 37-40 ◽  
Author(s):  
D. Raoult ◽  
J-P. Arzouni ◽  
M. C. Jambon ◽  
J. Beytout ◽  
O. Ramousse
Keyword(s):  
Western Blot ◽  
Spotted Fever ◽  
Mediterranean Spotted Fever

scholarly journals Mediterranean Spotted Fever in Central Tunisia

1994 ◽  
Vol 1 (2) ◽  
pp. 106-108 ◽  
Author(s):  
Letaïef Jemni ◽  
Houssem Hmouda ◽  
Mohamed Chakroun ◽  
Moez Ernez ◽  
Mezri May
Keyword(s):  
Spotted Fever ◽  
Mediterranean Spotted Fever ◽  
Central Tunisia

IMMUNOLOGICAL STUDIES IN MEDITERRANEAN SPOTTED FEVER

The Lancet ◽  
1982 ◽  
Vol 319 (8283) ◽  
pp. 1249 ◽  
Author(s):  
M.A. Piras ◽  
C. Gakis ◽  
M. Budroni ◽  
G. Andreoni
Keyword(s):  
Spotted Fever ◽  
Mediterranean Spotted Fever

scholarly journals Assessment of the Percentages of T-lymphocyte Subsets in the Peripheral Blood of Mediterranean Spotted Fever Patients

2020 ◽  
Vol 18 (2) ◽  
pp. 111-119
Author(s):  
Iv. Baltadzhiev ◽  
P. Pavlov
Keyword(s):  
T Cells ◽  
Disease Severity ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Spotted Fever ◽  
Healing Process ◽  
Cell Subset ◽  
Rickettsia Conorii ◽  
Mediterranean Spotted Fever ◽  
T Lymphocyte Subsets

Purpose: Mediterranean spotted fever (MSF) is a rickettsial disease. The aim was to evaluate the host immunе response to Rickettsia conorii. Material and methods: 62 patients were assigned into three groups: with mild, moderate or severe clinical forms of MSF. Controls were 32 healthy individuals. The diagnosis of MSF was confirmed by the indirect immunofluorescence assay. Immunophenotyping was performed using Epics XL-MCL Coulter. Results: The percentage of immune competent (CD3+) cells decreased, whereas that of helper/inducer (CD3+CD4+) and suppressor/cytotoxic (CD3+CD8+) did not change compared to controls. All three T-cell subset percentages did not parallel the disease severity. Naïve T-cells (CD4+CD45RA+) showed reduced levels, whereas activated memory (CD4+CD45RO+) T-cells did not change significantly. The percentage of activated (CD3+HLA-DR+) T-cells increased regardless of the disease severity, till the rise of stimulatory molecules (CD38+total) matched the disease severity forms. The percentage of costimulatory CD28-molecules corresponded to the disease severity as their levels increased significantly in mild forms and showed an evident downward trend towards the severe ones. Conclusion: Reduced T-lymphocyte subsets are likely related to trans-migration into perivascular inflammatory foci. The increased percentage of T-lymphocytes armed with stimulatory molecules probably reflects the mobilization of cell-mediated immune response in the healing process.

Mediterranean spotted fever in Salamanca, Spain. Epidemiological study in patients and serosurvey in animals and healthy human population

Acta Tropica ◽  
1989 ◽  
Vol 46 (5-6) ◽  
pp. 335-350 ◽  
Author(s):  
JoséIgnacio Herrero-Herrero ◽  
Ricardo Ruiz-Beltrán ◽  
A.Manuel Martín-Sánchez ◽  
Enrique J. García
Keyword(s):  
Epidemiological Study ◽  
Human Population ◽  
Spotted Fever ◽  
Mediterranean Spotted Fever ◽  
Healthy Human
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