Identification of cyclized calmodulin antagonists from a phage display random peptide library

1996 ◽  
Vol 1 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Heather Hanson Pierce ◽  
Nils Adey ◽  
Brian K. Kay
Keyword(s):  
Phage Display ◽  
Peptide Library ◽  
Calmodulin Antagonists ◽  
Random Peptide Library ◽  
Random Peptide

scholarly journals Epitope Fingerprinting for Recognition of the Polyclonal Serum Autoantibodies of Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Luiz Carlos de Oliveira-Júnior ◽  
Fabiana de Almeida Araújo Santos ◽  
Luiz Ricardo Goulart ◽  
Carlos Ueira-Vieira
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phage Display ◽  
Neural Tissue ◽  
Peptide Library ◽  
Phage Display Technology ◽  
Random Peptide Library ◽  
Random Peptide ◽  
Display Technology ◽  
Polyclonal Serum

Autoantibodies (aAb) associated with Alzheimer’s disease (AD) have not been sufficiently characterized and their exact involvement is undefined. The use of information technology and computerized analysis with phage display technology was used, in the present research, to map the epitope of putative self-antigens in AD patients. A 12-mer random peptide library, displayed on M13 phages, was screened using IgG from AD patients with two repetitions. Seventy-one peptides were isolated; however, only 10 were positive using the Elisa assay technique (Elisa Index > 1). The results showed that the epitope regions of the immunoreactive peptides, identified by phage display analysis, were on the exposed surfaces of the proteins. The putative antigens MAST1, Enah, MAO-A, X11/MINT1, HGF, SNX14, ARHGAP 11A, APC, and CENTG3, which have been associated with AD or have functions in neural tissue, may indicate possible therapeutic targets.

scholarly journals Screening specific polypeptides of breast cancer stem cells from a phage display random peptide library

2016 ◽  
Vol 12 (6) ◽  
pp. 4727-4731 ◽  
Author(s):  
Fei Liu ◽  
Chun-Ling Qi ◽  
Mian Kong ◽  
Ting-Ting Liu ◽  
Lei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Phage Display ◽  
Peptide Library ◽  
Breast Cancer Stem Cells ◽  
Random Peptide Library ◽  
Random Peptide

scholarly journals Identification of cell proliferation-associated epitope on CD98 oncoprotein using phage display random peptide library

2007 ◽  
Vol 98 (11) ◽  
pp. 1696-1700 ◽  
Author(s):  
Kunihiko Itoh ◽  
Kazuyuki Inoue ◽  
Hideki Hayashi ◽  
Toshio Suzuki ◽  
Takashi Masuko
Keyword(s):  
Cell Proliferation ◽  
Phage Display ◽  
Peptide Library ◽  
Random Peptide Library ◽  
Random Peptide

36. Random Peptide Library Based on a Spider Neurotoxin, and Utilization of the Library in in vitro Evolution Directed to GPCR Ligands

Toxicon ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 113 ◽  
Author(s):  
Tai Kubo ◽  
Seigo Ono ◽  
Tadashi Kimura ◽  
Suzuko Kobayashi ◽  
Tetsuro Kondo ◽  
...  
Keyword(s):  
Peptide Library ◽  
In Vitro Evolution ◽  
Random Peptide Library ◽  
Random Peptide

Definition of the peptide mimotope of cellular receptor for hepatitis C virus E2 protein using random peptide library

2001 ◽  
Vol 1 (1) ◽  
pp. 77
Author(s):  
In-Hee Lee ◽  
Jae-Eun Paik ◽  
Sang-Yong Seol ◽  
Dae-Hyun Seog ◽  
Sae-Gwang Park ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Peptide Library ◽  
Cellular Receptor ◽  
E2 Protein ◽  
Random Peptide Library ◽  
Random Peptide ◽  
Definition Of
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