Reversed Fick principle versus indirect calorimetry: Do systematic differences between methods represent intrapulmonary oxygen consumption?

1994 ◽  
Vol 20 (6) ◽  
pp. 457-458 ◽  
Author(s):  
A. Weyland
Keyword(s):  
Oxygen Consumption ◽  
Indirect Calorimetry ◽  
Fick Principle

scholarly journals Derived Oxygen Saturations are not Clinically Useful for the Calculation of Oxygen Consumption

1992 ◽  
Vol 20 (4) ◽  
pp. 460-463 ◽  
Author(s):  
J. A. Myburgh
Keyword(s):  
Oxygen Consumption ◽  
Critically Ill ◽  
Indirect Calorimetry ◽  
Critically Ill Patients ◽  
Severity Of Illness ◽  
Gas Monitoring ◽  
Limits Of Agreement ◽  
Fick Principle ◽  
The Mean ◽  
A Prospective Study

In critically ill patients, oxygen consumption (VO2) and delivery (Do2) are used to determine optimal haemodynamic management and to grade severity of illness. Vo2 may be measured by indirect calorimetry with metabolic gas monitoring systems or derived using the reverse Fick principle. Oxygen saturation (Sao2) may be measured directly by co-oximetry or derived by equations for incorporation into reverse Fick equations. A prospective study comparing Vo2 measured by these methods was performed in 20 critically ill patients. The mean Vo2 measured by the metabolic gas monitoring system (308 ± 63.9 ml/min) was significantly greater than that measured by reverse Fick using measured Sao2 (284 ± 72.0 ml/min) (P < 0.01). This difference may be due to intrapulmonary Vo2. When SaO2 was, calculated from three logarithmic equations and incorporated into the reverse Fick equations, calculated Vo2‘s were significantly greater (P < 0.001) than those measured by indirect calorimetry. Correlation was poor and wide limits of agreement (-118 to + 350 ml/min) were demonstrated. Vo2 should ideally be measured by indirect calorimetry in the critically ill, or if reverse Fick is used, SaO2 should be measured by co-oximetry as the use of equations for clinical measurement of SaO2 is clinically suspect.

Oxygen consumption in the early postinjury period: Use of continuous, on-line indirect calorimetry

2000 ◽  
Vol 28 (2) ◽  
pp. 395-401 ◽  
Author(s):  
Joel R. Peerless ◽  
Carol D. Epstein ◽  
James E. Martin ◽  
Alfred C. Pinchak ◽  
Mark A. Malangoni
Keyword(s):  
Oxygen Consumption ◽  
Indirect Calorimetry ◽  
On Line

IMPROVE ON PERFORMANCE OF INDIRECT CALORIMETRY FOR SMALL PRETERM INFANTS

2001 ◽  
Vol 13 (03) ◽  
pp. 109-115 ◽  
Author(s):  
SHIH-CHING LIN ◽  
CHING-HSING LUO ◽  
TSU-FUH YEH
Keyword(s):  
Oxygen Consumption ◽  
Energy Consumption ◽  
Clinical Research ◽  
Preterm Infants ◽  
Indirect Calorimetry ◽  
Carbon Dioxide Production ◽  
Laboratory Evaluation ◽  
Low Birth Weight Infants ◽  
Accuracy And Precision ◽  
Improved Performance

An indirect calorimetry system of measuring oxygen consumption and carbon dioxide production has been frequently used for preterm infants. The energy consumption and metabolic measurements are based on flow-through technology. The noninvasive measurement feature of the indirect calorimeter is widely used in pediatric clinical research. However, the indirect calorimeter has several limitations for small preterm infants, particularly the ill infant weighing < 1.0 kg. In this paper, we propose some technologies and methodologies to improve the performance of the indirect calorimetry. According to these technologies and methodologies, we redesign the indirect calorimeter proposed in our pervious study. The laboratory evaluation at the different alcohol combustion rates and several exhaust flow rates is used to survey the improved performance. As the results, the accuracy and precision is enhanced by these methods and the lowest oxygen consumption rate, 4.35 ml/min, fits for baby weight of 0.66 kg. It is demonstrated that the performances of new indirect calorimetry are substantially improved. It can be applied to calculate the energy consumption and metabolic rate for low-birth-weight infants in clinical research.

Percent relative cumulative frequency analysis in indirect calorimetry: application to studies of transgenic mice

2004 ◽  
Vol 82 (12) ◽  
pp. 1075-1083 ◽  
Author(s):  
Marc Riachi ◽  
Jean Himms-Hagen ◽  
Mary-Ellen Harper
Keyword(s):  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Metabolic Rate ◽  
Indirect Calorimetry ◽  
Uncoupling Protein ◽  
Resting Metabolic Rate ◽  
Large Data ◽  
Cumulative Frequency ◽  
And Control ◽  
Deficient Mice

Indirect calorimetry is commonly used in research and clinical settings to assess characteristics of energy expenditure. Respiration chambers in indirect calorimetry allow measurements over long periods of time (e.g., hours to days) and thus the collection of large sets of data. Current methods of data analysis usually involve the extraction of only a selected small proportion of data, most commonly the data that reflects resting metabolic rate. Here, we describe a simple quantitative approach for the analysis of large data sets that is capable of detecting small differences in energy metabolism. We refer to it as the percent relative cumulative frequency (PRCF) approach and have applied it to the study of uncoupling protein-1 (UCP1) deficient and control mice. The approach involves sorting data in ascending order, calculating their cumulative frequency, and expressing the frequencies in the form of percentile curves. Results demonstrate the sensitivity of the PRCF approach for analyses of oxygen consumption ([Formula: see text]02) as well as respiratory exchange ratio data. Statistical comparisons of PRCF curves are based on the 50th percentile values and curve slopes (H values). The application of the PRCF approach revealed that energy expenditure in UCP1-deficient mice housed and studied at room temperature (24 °C) is on average 10% lower (p < 0.0001) than in littermate controls. The gradual acclimation of mice to 12 °C caused a near-doubling of [Formula: see text] in both UCP1-deficient and control mice. At this lower environmental temperature, there were no differences in [Formula: see text] between groups. The latter is likely due to augmented shivering thermogenesis in UCP1-deficient mice compared with controls. With the increased availability of murine models of metabolic disease, indirect calorimetry is increasingly used, and the PRCF approach provides a novel and powerful means for data analysis.Key words: thermogenesis, oxygen consumption, metabolic rate, uncoupling protein, UCP.

scholarly journals Energy Expenditure of Daily Living Activities in 3- to 6-Year-Old Children

2016 ◽  
Vol 13 (s1) ◽  
pp. S3-S6 ◽  
Author(s):  
Wonwoo Byun ◽  
Allison Barry ◽  
Jung-Min Lee
Keyword(s):  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Young Children ◽  
Indirect Calorimetry ◽  
Daily Living ◽  
Physical Activities ◽  
Daily Living Activities ◽  
Watching Tv

Background:There has been a call for updating the Youth Compendium of Energy Expenditure (YCEE) by including energy expenditure (EE) data of young children (ie, < 6-year-old children). Therefore, this study examined the activity EE in 3 to 6 year old children using indirect calorimetry.Methods: Using Oxycon Mobile portable indirect calorimetry, both the oxygen consumption (VO2) and the EE of 28 children (Girls: 46%, Age: 4.8 ± 1.0, BMI: 16.4 ± 1.6) were measured while they performed various daily living activities (eg, watching TV, playing with toys, shooting baskets, soccer).Results:Across physical activities, averages of VO2 (ml·kg·min-1), VO2 (L·min-1), and EE ranged from 8.9 ± 1.5 to 33.3 ± 4.8 ml·kg·min-1, from 0.17 ± 0.04 to 0.64 ± 0.16 L·min-1, and from 0.8 ± 0.2 to 3.2 ± 0.7 kcal·min-1, respectively.Conclusions:These findings will contribute to the upcoming YCEE update.

The Surface of the Heart Leaks Oxygen

Physiology ◽  
1995 ◽  
Vol 10 (3) ◽  
pp. 129-133 ◽  
Author(s):  
DS Loiselle ◽  
JHGM van Beek ◽  
DA Mawson ◽  
PJ Hunter
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Oxygen Exchange ◽  
Fick Principle ◽  
Rate Of Oxygen Consumption

The rate of oxygen consumption of the heart is classically measured using the Fick principle. Uncritical application of this principle can cause errors of measurement, particularly when estimating cardiac basal metabolic rate. Consideration of these errors leads to a model that supports modern notions of oxygen exchange in perfused tissue.

Sign in / Sign up

Export Citation Format

Share Document