Spectrum and susceptibility of pathogens causing acute uncomplicated lower UTI in females and its correlation to bacteriologic outcome after single dose therapy with fosfomycin trometamol versus ofloxacin/Co-trimoxazole

Infection ◽  
1992 ◽  
Vol 20 (S4) ◽  
pp. S296-S301 ◽  
Author(s):  
K. G. Naber ◽  
Ursula Thyroff-Friesinger
Keyword(s):  
Single Dose ◽  
Dose Therapy ◽  
Fosfomycin Trometamol ◽  
Single Dose Therapy

scholarly journals COMPARISON OF FOSFOMYCIN TROMETAMOL WITH CIPROFLOXACIN FOR UNCOMPLICATED UTI DUE TO E.COLI IN WOMEN

2015 ◽  
Vol 22 (1) ◽  
Author(s):  
Heri Budiono ◽  
Sunaryo Hardjowijoto ◽  
Tarmono Djojodimedjo ◽  
Doddy M Soebadi ◽  
Agung Dwi Wahyu Widodo ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Single Dose ◽  
T Test ◽  
Therapeutic Effects ◽  
Chi Square ◽  
Dose Therapy ◽  
Fosfomycin Trometamol ◽  
Chi Square Test ◽  
Single Dose Therapy ◽  
Better Than

Objective: To compare clinical therapeutic effects (frequency, dysuria, and pyuria), microbiology, pharmacokinetics index Cmax/MIC Fosfomycin Trometamol 3 gr single dose with Ciprofloxacin 2 x 500 mg/12 hours for 5 days in the treatment of uncomplicated UTI in women due to Escherichia coli (E.Coli). Materials & Methods: Experimental observational design from February until July 2013. Twenty two women with uncomplicated UTI due to E.Coli performed clinical and microbiological examination. Pharmacokinetics index (Cmax/MIC) is looked for. Patients are divided 2 group, Ciprofloxacin 500 mg/12 hours 5 days and Fosfomycin Trometamol single dose. Repeat clinical and microbiological evaluation is performed in 7 days after therapy. Statistic analysis use Chi Square test, Paired T test, and Independent T test. Results: In the treatment of uncomplicated UTI in women, Fosfomycin Trometamol single dose therapy provides clinical cure (dysuria 81.2%, p = 0.338, frequency 90.9%, p = 0.004, pyuria 90.9%, p = 0.009) much better than Ciprofloxacin 500 mg/12 hours 5 days. Fosfomycin Trometamol single dose therapy also provides bacteriological eradication (100%) better than Ciprofloxacin 500 mg/12 hours 5 days (p = 0.035). Fosfomycin Trometamol single dose had a higher pharmacokinetics index (Cmax/MIC) compared to Ciprofloxacin 500 mg/12 hours (p = 0.035). Conclusion: Fosfomycin Trometamol single dose therapy is superior to Ciprofloxacin 500 mg/12 hours 5 days in the treatment of uncomplicated UTI in women. Keywords: Therapeutic effect, fosfomycin trometamol, ciprofloxacin, uncomplicated UTI, Escherichia coli.

Fosfomycin Trometamol versus Amoxycillin Single-Dose Therapy

2015 ◽  
pp. 185-190 ◽  
Author(s):  
A. Corbusier ◽  
F. Germeau ◽  
M. Bonadio ◽  
O. Maccanti ◽  
S. Benvenuti ◽  
...  
Keyword(s):  
Single Dose ◽  
Dose Therapy ◽  
Fosfomycin Trometamol ◽  
Single Dose Therapy

scholarly journals Single-Dose Therapy for Oral Candidiasis with Fluconazole in HIV-Infected Adults: A Pilot Study

1989 ◽  
Vol 159 (4) ◽  
pp. 806-807 ◽  
Author(s):  
J. P. Crave ◽  
A. Cajot ◽  
J. Bille ◽  
M. P. Glauser
Keyword(s):  
Single Dose ◽  
Pilot Study ◽  
Oral Candidiasis ◽  
Dose Therapy ◽  
Single Dose Therapy
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