Tidal volume, breathing frequency, and oxygen consumption at different pressure support levels in the early stage of weaning in patients without chronic obstructive polmonary disease

1992 ◽  
Vol 18 (4) ◽  
pp. 226-230 ◽  
Author(s):  
Ch. Hörmann ◽  
M. Baum ◽  
G. Luz ◽  
Ch. Putensen ◽  
G. Putz
Keyword(s):  
Oxygen Consumption ◽  
Tidal Volume ◽  
Pressure Support ◽  
Early Stage ◽  
Chronic Obstructive ◽  
Breathing Frequency ◽  
Tidal Volume Breathing

Ventilation standards for small mammals

1964 ◽  
Vol 19 (2) ◽  
pp. 360-362 ◽  
Author(s):  
Leonard I. Kleinman ◽  
Edward P. Radford
Keyword(s):  
Body Weight ◽  
Tidal Volume ◽  
Small Mammals ◽  
Artificial Respiration ◽  
Alveolar Ventilation ◽  
Breathing Frequency ◽  
Slide Rule ◽  
Physiological Dead Space ◽  
The Relationship ◽  
Tidal Volume Breathing

Ventilation standards for small mammals have been prepared on the basis of the relationship between alveolar ventilation and metabolism. On the assumptions of an average respiratory quotient of 0.85 and physiological dead space directly proportional to tidal volume, the relationship between tidal volume, breathing frequency, and body weight has been derived. The standards are presented in a graphic form and as a slide rule. animal ventilation; artificial respiration; tidal volume, breathing frequency and body weight relationship Submitted on August 15, 1963

A comparison of tidal volume, breathing frequency, and minute ventilation between two sitting postures in healthy adults

2003 ◽  
Vol 19 (2) ◽  
pp. 109-119 ◽  
Author(s):  
Merrill Landers ◽  
Greg Barker ◽  
Scott Wallentine ◽  
J. Wesley McWhorter ◽  
Claire Peel
Keyword(s):  
Tidal Volume ◽  
Minute Ventilation ◽  
Healthy Adults ◽  
Breathing Frequency ◽  
Tidal Volume Breathing

scholarly journals Breathing while altricial: the ontogeny of ventilatory chemosensitivity in red-winged blackbird (Agelaius phoeniceus) nestlings

2016 ◽  
Vol 311 (6) ◽  
pp. R1105-R1112 ◽  
Author(s):  
Edward M. Dzialowski ◽  
Tushar S. Sirsat ◽  
Sarah K. G. Sirsat ◽  
Edwin R. Price
Keyword(s):  
Oxygen Consumption ◽  
Tidal Volume ◽  
Aerobic Capacity ◽  
Minute Ventilation ◽  
Bird Species ◽  
Developmental Changes ◽  
Agelaius Phoeniceus ◽  
Breathing Frequency ◽  
Metabolic Capacity ◽  
Precocial Birds

Altricial bird species, like red-winged blackbirds, hatch at an immature state of functional maturity with limited aerobic capacity and no endothermic capacity. Over the next 10–12 days in the nest, red-winged blackbirds develop increased metabolic capacity before fledging. Although ontogeny of respiration has been described in precocial birds, ontogeny of ventilatory chemosensitivity is unknown in altricial species. Here we examined developmental changes in chemosensitivity of tidal volume (Vt), breathing frequency (ƒ), minute ventilation (V̇e), and whole animal oxygen consumption (V̇o2) from hatching to just before fledging in red-winged blackbirds on days 1, 3, 5, 7, and 9 posthatching (dph) in response to hypercapnia (2 and 4% CO2) and hypoxia (15 and 10% O2). Under control conditions, there was a developmental increase in V̇e with age due to increased Vt. Hypercapnic and hypoxic chemosensitivities were present as early as 1 dph. In response to hypoxia, 1, 3, and 9 dph nestlings increased V̇e at 10% O2, by increasing ƒ with some change in Vt in younger animals. In contrast to early neonatal altricial mammals, the hypoxic response of nestling red-winged blackbirds was not biphasic. In response to hypercapnia, 3 dph nestlings increased V̇e by increasing both ƒ and Vt. From 5 dph on, the hypercapnic increase in V̇e was accounted for by increased Vt and not ƒ. Chemosensitivity to O2 and CO2 matures early in nestling red-winged blackbirds, well before the ability to increase V̇o2 in response to cooling, and thus does not represent a limitation to the development of endothermy.

scholarly journals The Ability of Metabolomics to Discriminate Non-Small-Cell Lung Cancer Subtypes Depends on the Stage of the Disease and the Type of Material Studied

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3314
Author(s):  
Tomasz Kowalczyk ◽  
Joanna Kisluk ◽  
Karolina Pietrowska ◽  
Joanna Godzien ◽  
Miroslaw Kozlowski ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Early Stage ◽  
Chronic Obstructive ◽  
Liquid Chromatography Mass Spectrometry ◽  
Obstructive Pulmonary Disease ◽  
Cell Lung Carcinoma ◽  
Cancer Subtypes ◽  
Inflammatory State ◽  
Nsclc Patients

Identification of the NSCLC subtype at an early stage is still quite sophisticated. Metabolomics analysis of tissue and plasma of NSCLC patients may indicate new, and yet unknown, metabolic pathways active in the NSCLC. Our research characterized the metabolomics profile of tissue and plasma of patients with early and advanced NSCLC stage. Samples were subjected to thorough metabolomics analyses using liquid chromatography-mass spectrometry (LC-MS) technique. Tissue and/or plasma samples from 137 NSCLC patients were analyzed. Based on the early stage tissue analysis, more than 200 metabolites differentiating adenocarcinoma (ADC) and squamous cell lung carcinoma (SCC) subtypes as well as normal tissue, were identified. Most of the identified metabolites were amino acids, fatty acids, carnitines, lysoglycerophospholipids, sphingomyelins, plasmalogens and glycerophospholipids. Moreover, metabolites related to N-acyl ethanolamine (NAE) biosynthesis, namely glycerophospho (N-acyl) ethanolamines (GP-NAE), which discriminated early-stage SCC from ADC, have also been identified. On the other hand, the analysis of plasma of chronic obstructive pulmonary disease (COPD) and NSCLC patients allowed exclusion of the metabolites related to the inflammatory state in lungs and the identification of compounds (lysoglycerophospholipids, glycerophospholipids and sphingomyelins) truly characteristic to cancer. Our results, among already known, showed novel, thus far not described, metabolites discriminating NSCLC subtypes, especially in the early stage of cancer. Moreover, the presented results also indicated the activity of new metabolic pathways in NSCLC. Further investigations on the role of NAE biosynthesis pathways in the early stage of NSCLC may reveal new prognostic and diagnostic targets.

scholarly journals A population-based analysis of spirometry use and the prevalence of chronic obstructive pulmonary disease in lung cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sophie Corriveau ◽  
Gregory R. Pond ◽  
Grace H. Tang ◽  
John R. Goffin
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Early Stage ◽  
Advanced Lung Cancer ◽  
Public Healthcare ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Early Stage Disease ◽  
Morbidity Score

Abstract Background Chronic obstructive pulmonary disease (COPD) and lung cancer are associated diseases. COPD is underdiagnosed and thus undertreated, but there is limited data on COPD diagnosis in the setting of lung cancer. We assessed the diagnosis of COPD with lung cancer in a large public healthcare system. Methods Anonymous administrative data was acquired from ICES, which links demographics, hospital records, physician billing, and cancer registry data in Ontario, Canada. Individuals age 35 or older with COPD were identified through a validated, ICES-derived cohort and spirometry use was derived from physician billings. Statistical comparisons were made using Wilcoxon rank sum, Cochran-Armitage, and chi-square tests. Results From 2002 to 2014, 756,786 individuals were diagnosed with COPD, with a 2014 prevalence of 9.3%. Of these, 51.9% never underwent spirometry. During the same period, 105,304 individuals were diagnosed with lung cancer, among whom COPD was previously diagnosed in 34.9%. Having COPD prior to lung cancer was associated with lower income, a rural dwelling, a lower Charlson morbidity score, and less frequent stage IV disease (48 vs 54%, p < 0.001). Spirometry was more commonly undertaken in early stage disease (90.6% in stage I-II vs. 54.4% in stage III-IV). Conclusion Over a third of individuals with lung cancer had a prior diagnosis of COPD. Among individuals with advanced lung cancer, greater use of spirometry and diagnosis of COPD may help to mitigate respiratory symptoms.

Fixed ventilation during tidal volume breathing bronchial challenge may improve repeatability

Allergy ◽  
1987 ◽  
Vol 42 (7) ◽  
pp. 535-540 ◽  
Author(s):  
F. Madsen ◽  
L. Frølund ◽  
N. H. Nielsen ◽  
U. G. Svendsen ◽  
B. Weeke
Keyword(s):  
Tidal Volume ◽  
Bronchial Challenge ◽  
Tidal Volume Breathing
Sign in / Sign up

Export Citation Format

Share Document