Arterial thrombosis as clinical manifestation of congenital protein C deficiency

1991 ◽  
Vol 62 (5) ◽  
pp. 180-183 ◽  
Author(s):  
V. De Stefano ◽  
G. Leone ◽  
P. Micalizzi ◽  
L. Teofili ◽  
P. G. Falappa ◽  
...  
Keyword(s):  
Clinical Manifestation ◽  
Arterial Thrombosis ◽  
Protein C ◽  
Protein C Deficiency ◽  
Congenital Protein C Deficiency

scholarly journals Unusual Presentation of Congenital Protein C Deficiency as Arterial Thrombosis along with Venous Thromboembolism

2017 ◽  
Vol 12 (1) ◽  
pp. 34-36
Author(s):  
Tunaggina Afrin Khan ◽  
Saiful Ahmed ◽  
Abu Sadique Abdullah ◽  
Mohammad Sarwar Alam ◽  
SM Eftarjahan Kabir ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Arterial Thrombosis ◽  
Protein C ◽  
Unusual Presentation ◽  
Protein C Deficiency ◽  
Congenital Protein C Deficiency

Abstract not availableUniversity Heart Journal Vol. 12, No. 1, January 2016; 34-36

scholarly journals Congenital protein C deficiency causing major arterial thrombosis in a neonate

2019 ◽  
Vol 12 (7) ◽  
pp. e230034 ◽  
Author(s):  
Sanchari Chakravarty ◽  
Saugata Acharyya ◽  
Manas Kumar Mahapatra
Keyword(s):  
Lower Limb ◽  
Arterial Thrombosis ◽  
Protein C ◽  
Common Iliac Artery ◽  
Protein C Deficiency ◽  
History Of ◽  
The Common ◽  
Female Baby ◽  
Congenital Protein C Deficiency ◽  
Urokinase Infusion

A 9-day-old female baby presented with complaints of progressively worsening respiratory distress and lethargy. The parents were first cousins with history of multiple fetal losses in previous pregnancies. On examination, the baby was noted to be tachypnoeic, tachycardic with poor peripheral perfusion of the lower extremities. Femoral pulses on both sides were barely palpable. Echocardiography was normal. But cardiac catheterisation revealed the presence of an intraluminal obstruction of the distal aorta by a large thrombus. An attempt to dissolve the thrombus with urokinase infusion was unsuccessful. The affected vessels were then surgically explored and a large thrombus from the common iliac artery and distal abdominal aorta was removed. Following this, the child recovered uneventfully with return of lower limb pulsation. A thrombotic profile revealed the underlying diagnosis of congenital protein C deficiency responsible for the arterial thrombosis. This is an extremely unusual presentation, hardly ever been reported before.

Severe Arterial Cerebral Thrombosis in a Patient with Protein S Deficiency (Moderately Reduced Total and Markedly Reduced Free Protein S): A Family Study

1989 ◽  
Vol 61 (01) ◽  
pp. 144-147 ◽  
Author(s):  
A Girolami ◽  
P Simioni ◽  
A R Lazzaro ◽  
I Cordiano
Keyword(s):  
Arterial Thrombosis ◽  
Protein C ◽  
Protein S ◽  
Protein S Deficiency ◽  
Protein C Deficiency ◽  
Free Protein ◽  
Her Family ◽  
S Deficiency ◽  
Increased Risk ◽  
Patient Reported

SummaryDeficiency of protein S has been associated with an increased risk of thrombotic disease as already shown for protein C deficiency. Deficiencies of any of these two proteins predispose to venous thrombosis but have been only rarely associated with arterial thrombosis.In this study we describe a case of severe cerebral arterial thrombosis in a 44-year old woman with protein S deficiency. The defect was characterized by moderately reduced levels of total and markedly reduced levels of free protein S. C4b-bp level was normal. Protein C, AT III and routine coagulation tests were within the normal limits.In her family two other members showed the same defect. All the affected members had venous thrombotic manifestations, two of them at a relatively young age. No other risk factors for thrombotic episodes were present in the family members. The patient reported was treated with ASA and dipyridamole and so far there were no relapses.

Transient ischemic attack in a patient with congenital protein-c deficiency during treatment with stanozolol

1988 ◽  
Vol 29 (2) ◽  
pp. 120-121 ◽  
Author(s):  
Valerio de Stefano ◽  
Giuseppe Leone ◽  
Luciana Teofili ◽  
Rita Ferrelli ◽  
Giuseppe Pollari ◽  
...  
Keyword(s):  
Transient Ischemic Attack ◽  
Protein C ◽  
Protein C Deficiency ◽  
Ischemic Attack ◽  
Congenital Protein C Deficiency

Purpura Fulminans in a Chinese Boy With Congenital Protein C Deficiency

PEDIATRICS ◽  
1986 ◽  
Vol 77 (5) ◽  
pp. 670-676
Author(s):  
Patrick Yuen ◽  
Alfred Cheung ◽  
Hsiang Ju Lin ◽  
Faith Ho ◽  
Jun Mimuro ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Protein C ◽  
Purpura Fulminans ◽  
Fresh Frozen Plasma ◽  
Protein C Deficiency ◽  
Intravascular Coagulation ◽  
The Family ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Congenital Protein C Deficiency

Severe and recurrent purpura fulminans developed in a Chinese boy at one day of age. Results of coagulation studies performed on the patient during attacks were compatible with the diagnosis of disseminated intravascular coagulation. Subsequent investigations have revealed that the patient is homozygous and that his parents are heterozygous for protein C deficiency. Cryoprecipitate and fresh frozen plasma induced a remission, and administration of warfarin has been successful in preventing recurrence of attacks for as long as 8 months without infusion of any plasma components. None of the family members who are heterozygous for protein C deficiency have had thrombotic episodes.

scholarly journals Aortic Mural Thrombus Associated with Congenital Protein C Deficiency in an Elderly Patient

2020 ◽  
Vol 27 (1) ◽  
pp. 100-103
Author(s):  
Kazuki Ueda ◽  
Eriko Morishita ◽  
Hironaga Shiraki ◽  
Shunzo Matsuoka ◽  
Shinsaku Imashuku
Keyword(s):  
Elderly Patient ◽  
Protein C ◽  
Mural Thrombus ◽  
Protein C Deficiency ◽  
Congenital Protein C Deficiency

scholarly journals A Study of Congenital Protein C Deficiency With Infancy Onset of CADASIL in a Chinese Baby

2019 ◽  
Vol 41 (4) ◽  
pp. e210-e215 ◽  
Author(s):  
Xiuli Yuan ◽  
Changgang Li ◽  
Xiaowen Chen ◽  
Liwei Liu ◽  
Guosheng Liu ◽  
...  
Keyword(s):  
Protein C ◽  
Protein C Deficiency ◽  
Congenital Protein C Deficiency
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