Large deviations and asymptotic efficiency of a statistic of integral type. II

1984 ◽  
Vol 24 (5) ◽  
pp. 585-603 ◽  
Author(s):  
Ya. Yu. Nikitin
Keyword(s):  
Large Deviations ◽  
Asymptotic Efficiency ◽  
Type Ii ◽  
Integral Type

scholarly journals Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency

2021 ◽  
Author(s):  
Andreas Schmiedl ◽  
Inga Wagener ◽  
Meike Jungen ◽  
Stephan von Hörsten ◽  
Michael Stephan
Keyword(s):  
T Cells ◽  
Cell Sorting ◽  
Lung Development ◽  
Immune Status ◽  
Immune Cell ◽  
Type Ii ◽  
Integral Type ◽  
Lung Maturation ◽  
Rat Pups ◽  
Fischer Rats

AbstractDipeptidyl-peptidase IV (CD26), a multifactorial integral type II protein, is expressed in the lungs during development and is involved in inflammation processes. We tested whether daily LPS administration influences the CD26-dependent retardation in morphological lung development and induces alterations in the immune status. Newborn Fischer rats with and without CD26 deficiency were nebulized with 1 µg LPS/2 ml NaCl for 10 min from days postpartum (dpp) 3 to 9. We used stereological methods and fluorescence activated cell sorting (FACS) to determine morphological lung maturation and alterations in the pulmonary leukocyte content on dpp 7, 10, and 14. Daily LPS application did not change the lung volume but resulted in a significant retardation of alveolarization in both substrains proved by significantly lower values of septal surface and volume as well as higher mean free distances in airspaces. Looking at the immune status after LPS exposure compared to controls, a significantly higher percentage of B lymphocytes and decrease of CD4+CD25+ T cells were found in both subtypes, on dpp7 a significantly higher percentage of CD4 T+ cells in CD26+ pups, and a significantly higher percentage of monocytes in CD26− pups. The percentage of T cells was significantly higher in the CD26-deficient group on each dpp. Thus, daily postnatal exposition to low doses of LPS for 1 week resulted in a delay in formation of secondary septa, which remained up to dpp 14 in CD26− pups. The retardation was accompanied by moderate parenchymal inflammation and CD26-dependent changes in the pulmonary immune cell composition.

The role of the integral type II transmembrane protein BRI2 in health and disease

2021 ◽  
Author(s):  
Filipa Martins ◽  
Isabela Santos ◽  
Odete A. B. da Cruz e Silva ◽  
Simone Tambaro ◽  
Sandra Rebelo
Keyword(s):  
Transmembrane Protein ◽  
Type Ii ◽  
Integral Type ◽  
Health And Disease

scholarly journals On the Large Deviations Theorem of Weaker Types

2017 ◽  
Vol 27 (08) ◽  
pp. 1750127 ◽  
Author(s):  
Xinxing Wu ◽  
Xiong Wang ◽  
Guanrong Chen
Keyword(s):  
Dynamical System ◽  
Dynamical Systems ◽  
Large Deviations ◽  
Ergodic Measure ◽  
Type I ◽  
Type Ii ◽  
Text Type ◽  
Type Iii ◽  
Ergodic Dynamical System ◽  
Uniquely Ergodic

In this paper, we introduce the concepts of the large deviations theorem of weaker types, i.e. type I, type I[Formula: see text], type II, type II[Formula: see text], type III, and type III[Formula: see text], and present a systematic study of the ergodic and chaotic properties of dynamical systems satisfying the large deviations theorem of various types. Some characteristics of the ergodic measure are obtained and then applied to prove that every dynamical system satisfying the large deviations theorem of type I[Formula: see text] is ergodic, which is equivalent to the large deviations theorem of type II[Formula: see text] in this regard, and that every uniquely ergodic dynamical system restricted on its support satisfies the large deviations theorem. Moreover, we prove that every dynamical system satisfying the large deviations theorem of type III is an [Formula: see text]-system.

Asymptotic efficiency of exponentiality tests based on order statistics characterization

2010 ◽  
Vol 17 (4) ◽  
pp. 749-763
Author(s):  
Ya. Yu. Nikitin ◽  
Ksenia Yu. Volkova
Keyword(s):  
Large Deviations ◽  
Order Statistics ◽  
Asymptotic Efficiency ◽  
Bahadur Efficiency ◽  
Limiting Distributions ◽  
Scale Invariant ◽  
New Statistics

Abstract We propose new scale-invariant tests for exponentiality based on the characterization in terms of order statistics. Limiting distributions and large deviations of new statistics are described and their local Bahadur efficiency for common alternatives is calculated.

Sign in / Sign up

Export Citation Format

Share Document