Noncoding control region of naturally occurring BK virus variants: Sequence comparison and functional analysis

Virus Genes ◽  
1995 ◽  
Vol 10 (3) ◽  
pp. 261-275 ◽  
Author(s):  
Ugo Moens ◽  
Terje Johansen ◽  
John Inge Johnsen ◽  
Ole Morten Seternes ◽  
Terje Traavik
Keyword(s):  
Functional Analysis ◽  
Control Region ◽  
Sequence Comparison ◽  
Bk Virus ◽  
Naturally Occurring ◽  
Noncoding Control Region

A Suppressive Effect of Cyclosporine A on Replication and Noncoding Control Region Activation of Polyomavirus BK Virus

2010 ◽  
Vol 89 (3) ◽  
pp. 299-306 ◽  
Author(s):  
Yi-Jung Li ◽  
Cheng-Hao Weng ◽  
Wen-Chi Lai ◽  
Hsin-Hsu Wu ◽  
Yung-Chang Chen ◽  
...  
Keyword(s):  
Control Region ◽  
Cyclosporine A ◽  
Suppressive Effect ◽  
Bk Virus ◽  
Noncoding Control Region ◽  
Polyomavirus Bk

scholarly journals Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Imran A. Memon ◽  
Bijal A. Parikh ◽  
Monique Gaudreault-Keener ◽  
Rebecca Skelton ◽  
Gregory A. Storch ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dna Sequencing ◽  
Control Region ◽  
Calcineurin Inhibitor ◽  
Pcr Amplification ◽  
Virus Genome ◽  
Bk Virus ◽  
Plasma Samples ◽  
Peak Viremia ◽  
Noncoding Control Region

Changes in the BK virus archetypal noncoding control region (NCCR) have been associated with BK-virus-associated nephropathy (BKVAN). Whether sustained viremia, a surrogate for BKVAN, is associated with significant changes in the BK-NCCR is unknown. We performed PCR amplification and sequencing of (1) stored urine and (2) plasma samples from the time of peak viremia from 11 patients with sustained viremia who participated in a 200-patient clinical trial. The antimetabolite was withdrawn for BK viremia and reduction of the calcineurin inhibitor for sustained BK viremia. DNA sequencing from the 11 patients with sustained viremia revealed 8 insertions, 16 transversions, 3 deletions, and 17 transitions. None were deemed significant. No patient developed clinically evident BKVAN. Our data support, at a genomic level, the effectiveness of reduction of immunosuppression for prevention of progression from viremia to BKVAN.

Polyomavirus JC reactivation and noncoding control region sequence analysis in pediatric Crohn's disease patients treated with infliximab

2011 ◽  
Vol 17 (4) ◽  
pp. 303-313 ◽  
Author(s):  
Anna Bellizzi ◽  
Elena Anzivino ◽  
Federica Ferrari ◽  
Giovanni Di Nardo ◽  
Maria Teresa Colosimo ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Sequence Analysis ◽  
Crohn's Disease ◽  
Control Region ◽  
Control Region Sequence ◽  
Region Sequence ◽  
Polyomavirus Jc ◽  
Noncoding Control Region
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