Flumazenil in the treatment of hepatic encephalopathy in children with fulminant liver failure

1995 ◽  
Vol 21 (3) ◽  
pp. 253-256 ◽  
Author(s):  
D. Devictor ◽  
C. Tahiri ◽  
C. Lanchier ◽  
Y. Navelet ◽  
P. Durand ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Liver Failure ◽  
Fulminant Liver Failure

Hepatic Encephalopathy and Liver Failure in Pediatric Patient with hepatitis A

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Shaima’a Dakhel AbdulHassa
Keyword(s):  
Hepatic Encephalopathy ◽  
Liver Failure ◽  
Hepatitis A ◽  
Gene Sequence ◽  
Stool Examination ◽  
Age Group ◽  
Significant Difference ◽  
Medical City ◽  
Sequence Method ◽  
Stool Samples

Gairdia lamblia is one of parasites that cause intestinal problems within the human body, particularly private travelers and children. In this study a total of (100) diarrheal patients, 20 patients with Giardiasis were identified by fecal antigen. 9 out of 20(20%) of them were infected by fecal antigen, while 9(9%) of them were infected by using the screening general stool examination (GSE). The stool samples were collected from patient how vested the Medical City/ Baghdad and Tikrit teaching Hospital during the period from 1 st may 2018 to 1 February 2019. The results revealing a significant difference (p andlt; 0.05) between the two methods of detection for G. lamblia (Fecal antigen method and GSE). IT has been shown that out of 20 infected individuals 12(12%) were males and 8(8%) were females, indicating regarding no significant deference in the distribution of Giardiasis among genders. In regard the age, our results showed that highest infection rate 8(3.2%) was recorded in the age group (10-19) years, followed by the age group (20-2) years which was 692.4%). In this study five mutations were recorded at position (926, 1094, 1202and 1304), by using tpiA gene sequence method, and tpiB gene was on point mutation change (G254A), in the position (85) of triose phosphate isomease.

Cirrhosis and acute on chronic liver failure: is ammonia a predictor of hepatic encephalopathy and mortality?

2017 ◽  
Vol 66 (1) ◽  
pp. S559
Author(s):  
M. Sheikh ◽  
N. Arias ◽  
K. Thomsen ◽  
R. Gallego-Durán ◽  
B. Agarwal ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure

Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy

Blood ◽  
2003 ◽  
Vol 102 (4) ◽  
pp. 1525-1528 ◽  
Author(s):  
Brian J. Ruscito ◽  
Neil L. Harrison
Keyword(s):  
Cognitive Impairment ◽  
Hepatic Encephalopathy ◽  
Synaptic Transmission ◽  
Liver Failure ◽  
Gabaa Receptor ◽  
Protoporphyrin Ix ◽  
Aminobutyric Acid ◽  
Endogenous Ligands ◽  
Inhibitory Synaptic Transmission ◽  
Clinical Observations

Abstract Liver failure is often accompanied by cognitive impairment and coma, a syndrome known as hepatic encephalopathy (HE). The administration of flumazenil, a benzodiazepine (BZ) antagonist, is effective in reversing the symptoms of HE in many patients. These clinical observations gave rise to notions of an endogenous BZ-like mechanism in HE, but to date no viable candidate compounds have been characterized. We show here that the hemoglobin (Hb) metabolites hemin and protoporphyrin IX (PPIX) interact with the BZ site on the γ-aminobutyric acid (GABAA) receptor and enhance inhibitory synaptic transmission in a manner similar to diazepam and zolpidem. This finding suggests that hemin and PPIX are neuroactive porphyrins capable of acting as endogenous ligands for the central BZ site. The accumulation of these porphyrins under pathophysiologic conditions provides a potentially novel mechanism for the central manifestations of HE.

Hepatic amyloidosis as a case of fatal fulminant liver failure

2021 ◽  
Vol 45 (1) ◽  
pp. 101506
Author(s):  
Flora Charpy ◽  
Antoine Debourdeau ◽  
Lucile Boivineau ◽  
Magdalena Meszaros ◽  
Lucy Meunier
Keyword(s):  
Liver Failure ◽  
Fulminant Liver Failure ◽  
Hepatic Amyloidosis
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