Treatment of acute exacerbations of chronic bronchitis: Comparison of trovafloxacin and amoxicillin in a multicentre, double-blind, double-dummy study

1998 ◽  
Vol 17 (6) ◽  
pp. 441-446 ◽  
Author(s):  
B. O'Doherty ◽  
R. Daniel ◽  
Keyword(s):  
Chronic Bronchitis ◽  
Double Blind ◽  
Acute Exacerbations

Cefodizime and cefotaxime in acute exacerbations of chronic bronchitis: a randomized double-blind prospective study in 180 patients

1990 ◽  
Vol 25 (3) ◽  
pp. 413-422 ◽  
Author(s):  
F. P. V. Maesen ◽  
B. I. Davies ◽  
J. J. A. M. van den Bergh ◽  
H. L. L. Gubbelmans ◽  
J. C. E. Meek ◽  
...  
Keyword(s):  
Prospective Study ◽  
Chronic Bronchitis ◽  
Double Blind ◽  
Acute Exacerbations

Oral Telithromycin 800 mg Once Daily for 5 Days versus Cefuroxime Axetil 500 mg Twice Daily for 10 Days in Adults with Acute Exacerbations of Chronic Bronchitis

2003 ◽  
Vol 31 (3) ◽  
pp. 157-169 ◽  
Author(s):  
MJ Zervos ◽  
AM Heyder ◽  
B Leroy
Keyword(s):  
Chronic Bronchitis ◽  
Cefuroxime Axetil ◽  
Double Blind ◽  
Once Daily ◽  
Parallel Group ◽  
Acute Exacerbations ◽  
Cure Rates ◽  
Parallel Group Trial ◽  
Post Therapy ◽  
Group Trial

The efficacy and safety of a 5-day regimen of 800 mg telithromycin once daily was compared with a standard 10-day regimen of 500 mg cefuroxime axetil twice daily in a multicentre, randomized, double-blind, parallel-group trial involving 376 patients with acute exacerbations of chronic bronchitis (AECB). In clinically evaluable patients ( n = 282), post-therapy clinical cure rates were 86.4% with telithromycin and 83.1% with cefuroxime axetil. In bacteriologically evaluable patients ( n = 53), eradication or presumed eradication of the pathogen was achieved in 76.0% and 78.6% of telithromycin and cefuroxime axetil patients, respectively. Adverse events were mostly mild; the most common were diarrhoea (12.8% versus 11.8%) and nausea (8.9% versus 3.2%) in telithromycin and cefuroxime axetil patients, respectively. The 5-day regimen of 800 mg telithromycin once daily was similar in efficacy and equally well tolerated as a 10-day regimen of 500 mg cefuroxime axetil twice daily in adults with AECB.

Randomized, Double-Blind Study of Prulifloxacin versus Ciprofloxacin in Patients with Acute Exacerbations of Chronic Bronchitis

Respiration ◽  
2002 ◽  
Vol 69 (3) ◽  
pp. 217-222 ◽  
Author(s):  
Carlo Grassi ◽  
Enrica Salvatori ◽  
Maria Teresa Rosignoli ◽  
Paolo Dionisio
Keyword(s):  
Chronic Bronchitis ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Acute Exacerbations

A Comparative Trial of Minocin (Minocycline Hydrochloride) and Ampicillin in the Treatment of Acute Exacerbations of Chronic Bronchitis

1975 ◽  
Vol 3 (5) ◽  
pp. 304-308 ◽  
Author(s):  
G R F Burrow ◽  
A S Fox ◽  
R J E Daniel
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Chronic Bronchitis ◽  
Therapeutic Efficacy ◽  
Comparative Trial ◽  
Double Blind ◽  
Significant Difference ◽  
Acute Exacerbations ◽  
Minocycline Hydrochloride ◽  
Long Acting

One hundred and fifteen patients suffering from acute exacerbations of chronic bronchitis took part in a double-blind, multicentre, clinical trial designed to compare the therapeutic efficacy and tolerability of ampicillin and minocycline hydrochloride, a new, long-acting, semi-synthetic tetracycline. Both antibiotics were equally successful in treatment, there being no statistically significant difference between the two in any of the parameters studied. Side-effects were few and far between. Only one patient out of the 57 who took minocycline, complained of dizziness.

scholarly journals Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies

Thorax ◽  
2008 ◽  
Vol 63 (5) ◽  
pp. 415-422 ◽  
Author(s):  
R El Moussaoui ◽  
B M Roede ◽  
P Speelman ◽  
P Bresser ◽  
J M Prins ◽  
...  
Keyword(s):  
Chronic Bronchitis ◽  
Antibiotic Treatment ◽  
Meta Analysis ◽  
Double Blind ◽  
Short Course ◽  
Acute Exacerbations
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