In vivo binding of p,p′-DDE to human serum proteins

1973 ◽  
Vol 9 (2) ◽  
pp. 70-74 ◽  
Author(s):  
W. P. Schoor
Keyword(s):  
Human Serum ◽  
Serum Proteins ◽  
In Vivo Binding ◽  
Human Serum Proteins

scholarly journals Unraveling the Antioxidant, Binding and Health-Protecting Properties of Phenolic Compounds of Beers with Main Human Serum Proteins: In Vitro and In Silico Approaches

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4962
Author(s):  
Raja Mohamed Beema Shafreen ◽  
Selvaraj Alagu Lakshmi ◽  
Shunmugiah Karutha Pandian ◽  
Yong Seo Park ◽  
Young Mo Kim ◽  
...  
Keyword(s):  
Human Serum ◽  
In Silico ◽  
Serum Proteins ◽  
In Silico Analysis ◽  
Cardiovascular Effects ◽  
In Vivo Studies ◽  
In Silico Studies ◽  
Human Serum Proteins

Our recently published in vivo studies and growing evidence suggest that moderate consumption of beer possesses several health benefits, including antioxidant and cardiovascular effects. Although beer contains phenolic acids and flavonoids as the major composition, and upon consumption, the levels of major components increase in the blood, there is no report on how these beer components interact with main human serum proteins. Thus, to address the interaction potential between beer components and human serum proteins, the present study primarily aims to investigate the components of beer from different industrial sources as well as their mode of interaction through in silico analysis. The contents of the bioactive compounds, antioxidant capacities and their influence on binding properties of the main serum proteins in human metabolism (human serum albumin (HSA), plasma circulation fibrinogen (PCF), C-reactive protein (CRP) and glutathione peroxidase 3 (GPX3)) were studied. In vitro and in silico studies indicated that phenolic substances presented in beer interact with the key regions of the proteins to enhance their antioxidant and health properties. We hypothesize that moderate consumption of beer could be beneficial for patients suffering from coronary artery disease (CAD) and other health advantages by regulating the serum proteins.

scholarly journals Bioactivities of Phenolic Compounds from Kiwifruit and Persimmon

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4405
Author(s):  
Young-Mo Kim ◽  
Faridah Abas ◽  
Yong-Seo Park ◽  
Yang-Kyun Park ◽  
Kyung-Sik Ham ◽  
...  
Keyword(s):  
Human Serum ◽  
Serum Proteins ◽  
Antioxidant Properties ◽  
Fluorescence Measurements ◽  
3D Fluorescence Spectroscopy ◽  
Human Proteins ◽  
Artery Disease ◽  
Spectroscopy Studies ◽  
Human Serum Proteins

Fruit used in the common human diet in general, and kiwifruit and persimmon particularly, displays health properties in the prevention of heart disease. This study describes a combination of bioactivity, multivariate data analyses and fluorescence measurements for the differentiating of kiwifruit and persimmon, their quenching and antioxidant properties. The metabolic differences are shown, as well in the results of bioactivities and antioxidant capacities determined by ABTS, FRAP, CUPRAC and DPPH assays. To complement the bioactivity of these fruits, the quenching properties between extracted polyphenols and human serum proteins were determined by 3D-fluorescence spectroscopy studies. These properties of the extracted polyphenols in interaction with the main serum proteins in the human metabolism (human serum albumin (HSA), α-β-globulin (α-β G) and fibrinogen (Fgn)), showed that kiwifruit was more reactive than persimmon. There was a direct correlation between the quenching properties of the polyphenols of the investigated fruits with serum human proteins, their relative quantification and bioactivity. The results of metabolites and fluorescence quenching show that these fruits possess multiple properties that have a great potential to be used in industry with emphasis on the formulation of functional foods and in the pharmaceutical industry. Based on the quenching properties of human serum proteins with polyphenols and recent reports in vivo on human studies, we hypothesize that HSA, α-β G and Fgn will be predictors of coronary artery disease (CAD).

TESTOSTERONE BINDING BY HUMAN SERUM PROTEINS

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S105 ◽  
Author(s):  
O. A. Lea ◽  
K. F. Støa
Keyword(s):  
Human Serum ◽  
Serum Proteins ◽  
Human Serum Proteins

scholarly journals A Peptide Found in Human Serum, Derived from the C-Terminus of Albumin, Shows Antifungal Activity In Vitro and In Vivo

2020 ◽  
Vol 8 (10) ◽  
pp. 1627
Author(s):  
Tecla Ciociola ◽  
Pier Paolo Zanello ◽  
Tiziana D’Adda ◽  
Serena Galati ◽  
Stefania Conti ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Human Serum ◽  
Fungicidal Activity ◽  
Galleria Mellonella ◽  
Serum Proteins ◽  
Morphological Alterations ◽  
C Terminus ◽  
Different Sources

The growing problem of antimicrobial resistance highlights the need for alternative strategies to combat infections. From this perspective, there is a considerable interest in natural molecules obtained from different sources, which are shown to be active against microorganisms, either alone or in association with conventional drugs. In this paper, peptides with the same sequence of fragments, found in human serum, derived from physiological proteins, were evaluated for their antifungal activity. A 13-residue peptide, representing the 597–609 fragment within the albumin C-terminus, was proved to exert a fungicidal activity in vitro against pathogenic yeasts and a therapeutic effect in vivo in the experimental model of candidal infection in Galleria mellonella. Studies by confocal microscopy and transmission and scanning electron microscopy demonstrated that the peptide penetrates and accumulates in Candida albicans cells, causing gross morphological alterations in cellular structure. These findings add albumin to the group of proteins, which already includes hemoglobin and antibodies, that could give rise to cryptic antimicrobial fragments, and could suggest their role in anti-infective homeostasis. The study of bioactive fragments from serum proteins could open interesting perspectives for the development of new antimicrobial molecules derived by natural sources.

scholarly journals THE CYSTINE CONTENT OF HUMAN SERUM PROTEINS

1933 ◽  
Vol 100 (3) ◽  
pp. 775-778 ◽  
Author(s):  
L.R. Tuchman ◽  
Miriam Reiner
Keyword(s):  
Human Serum ◽  
Serum Proteins ◽  
Cystine Content ◽  
Human Serum Proteins

scholarly journals Proteome analysis of human serum proteins adsorbed onto different titanium surfaces used in dental implants

Biofouling ◽  
2016 ◽  
Vol 33 (1) ◽  
pp. 98-111 ◽  
Author(s):  
Francisco Romero-Gavilán ◽  
N. C. Gomes ◽  
Joaquin Ródenas ◽  
Ana Sánchez ◽  
Mikel Azkargorta ◽  
...  
Keyword(s):  
Human Serum ◽  
Dental Implants ◽  
Serum Proteins ◽  
Proteome Analysis ◽  
Titanium Surfaces ◽  
Human Serum Proteins
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