Intestinal function after total gastrectomy and possible consequences of gastric replacement

1987 ◽  
Vol 11 (6) ◽  
pp. 713-719 ◽  
Author(s):  
Lars Olbe ◽  
Lars Lundell
Keyword(s):  
Total Gastrectomy ◽  
Intestinal Function ◽  
Gastric Replacement

PS01.158: WHAT IS THE IDEAL RECONSTRUCTIVE TECHNIQUE FOR TYPE 2 GEJ TUMOURS—ESOPHAGOGASTROSTOMY OR ESOPHAGOJEJUNOSTOMY

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 94-94
Author(s):  
Servarayan Chandramohan ◽  
Visvarath Varadharajan ◽  
Madeshwaran Chinnathambi ◽  
Kanagavel Manickavasagam ◽  
Abishai Jebaraj ◽  
...  
Keyword(s):  
Blood Loss ◽  
Functional Outcome ◽  
Total Gastrectomy ◽  
Locally Advanced ◽  
Operating Time ◽  
Distal Margin ◽  
Gastric Replacement ◽  
Ivor Lewis ◽  
Significant Difference

Abstract Background In the management of OG junction tumors the border issue arises in type 2 cancers. It can be managed with various options like esophago gastrectomy (Ivor Lewis), transabdominal extended transhiatal gastrectomy or total esophago gastrectomy depends upon the extent strectomy of the tumor above and below. After resection the reconstruction can be either with stomach or jejunum or colon. However the functional result after either of these procedures varies. The aim of this study is to know the functional outcome of different reconstruction methods after esophagogastrectomy for locally advanced Type 2 OG junction tumours. Methods 148 consecutive patients who underwent surgery for OG junction tumors in the last 6 years were evaluated. Of them 62 locally advanced type2 OG junction tumors were included in our study. 26 underwent Ivor Levis procedure with gastric replacement. 36 underwent extended transhiatal gastrectomy with esophago jejunal anastamosis. Intra operative details like pyloroplasty, Operative time, blood loss, the distal margin, nodal clearance was noted. The functional outcome since immediate postoperative period to 1 year of follow up is reviewed retrospectively and prospectively in few cases. Results There is no significant difference in operating time, blood loss. Two patients with Partial gastrectomy had positive distal margin even though it is not statistically significant. The average number of nodes harvested is higher with total gastrectomy group with jejunal anastamosis and it is statistically significant between 2 groups (P < 0.05).The GERD is more with gastric conduit when compared to Jejunal reconstruction but the weight loss is more with jejunal reconstruction when compared with gastric reconstruction. Conclusion The functional outcome and oncological outcome are superior with jejunal reconstruction after total gastrectomy when compared with gastric reconstruction after Ivor Lewis procedure. Disclosure All authors have declared no conflicts of interest.

Total gastrectomy for cancer: Is reconstruction or a gastric replacement reservoir essential?

1994 ◽  
Vol 18 (6) ◽  
pp. 883-888 ◽  
Author(s):  
Ant�nio Castro Mendes de Almeida ◽  
Noel Medina Dos Santos ◽  
Fernando Jos� Aldeia
Keyword(s):  
Total Gastrectomy ◽  
Gastric Replacement

Hepatic-intestinal function after total gastrectomy

2002 ◽  
Vol 34 (2) ◽  
pp. 152
Author(s):  
A. Tocchi ◽  
G. Mazzoni ◽  
G. Liotta ◽  
L. Lepre ◽  
M. Miccini
Keyword(s):  
Total Gastrectomy ◽  
Intestinal Function

Comparative Analysis of Two Types of Gastric Replacement After Total Gastrectomy

1979 ◽  
pp. 281-286 ◽  
Author(s):  
D. Kummer ◽  
G. Kieninger ◽  
K. Anger ◽  
H. P. Maier
Keyword(s):  
Comparative Analysis ◽  
Total Gastrectomy ◽  
Gastric Replacement

Clinical experience with a new method of gastric replacement following total gastrectomy

1979 ◽  
Vol 3 (6) ◽  
pp. 737-741 ◽  
Author(s):  
G. Kieninger ◽  
L. Koslowski ◽  
J. Durst ◽  
D. Kummer ◽  
K. -J. Wolf
Keyword(s):  
Total Gastrectomy ◽  
Clinical Experience ◽  
New Method ◽  
Gastric Replacement

Pernicious Anemia Following Total Gastrectomy for Giant Hypertrophy of the Gastric Rugae (Menetrier’s Disease)

1960 ◽  
Vol 39 (3) ◽  
pp. 347-350 ◽  
Author(s):  
Earl E. Gambill ◽  
Donald C. Campbell ◽  
Donald C. Balfour ◽  
John M. Waugh ◽  
Malcolm B. Dockerty
Keyword(s):  
Pernicious Anemia ◽  
Total Gastrectomy ◽  
Menetrier’S Disease ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

Total gastrectomy and small intestinal cholesterol synthesis in diabetic rats

Diabetes ◽  
1989 ◽  
Vol 38 (2) ◽  
pp. 219-224
Author(s):  
K. R. Feingold ◽  
Q. H. Zeng ◽  
M. Soued ◽  
A. Siperstein ◽  
M. K. Serio ◽  
...  
Keyword(s):  
Total Gastrectomy ◽  
Cholesterol Synthesis ◽  
Diabetic Rats ◽  
Small Intestinal

MicroRNA Determines the Fate of Intestinal Epithelial Cell Differentiation and Regulates Intestinal Diseases

2019 ◽  
Vol 20 (7) ◽  
pp. 666-673 ◽  
Author(s):  
Sujuan Ding ◽  
Gang Liu ◽  
Hongmei Jiang ◽  
Jun Fang
Keyword(s):  
Target Genes ◽  
Gastrointestinal Disease ◽  
Intestinal Barrier ◽  
Vital Role ◽  
Intestinal Barrier Function ◽  
Intestinal Epithelial ◽  
Intestinal Function ◽  
Cell Fates ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

The rapid self-renewal of intestinal epithelial cells enhances intestinal function, promotes the nutritional needs of animals and strengthens intestinal barrier function to resist the invasion of foreign pathogens. MicroRNAs (miRNAs) are a class of short-chain, non-coding RNAs that regulate stem cell proliferation and differentiation by down-regulating hundreds of conserved target genes after transcription via seed pairing to the 3&#039; untranslated regions. Numerous studies have shown that miRNAs can improve intestinal function by participating in the proliferation and differentiation of different cell populations in the intestine. In addition, miRNAs also contribute to disease regulation and therefore not only play a vital role in the gastrointestinal disease management but also act as blood or tissue biomarkers of disease. As changes to the levels of miRNAs can change cell fates, miRNA-mediated gene regulation can be used to update therapeutic strategies and approaches to disease treatment.

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