Early infectious complications in allogeneic marrow transplant recipients with acute leukemia: Effects of prophylactic measures

Infection ◽  
1983 ◽  
Vol 11 (5) ◽  
pp. 243-250 ◽  
Author(s):  
C. D. Buckner ◽  
R. A. Clift ◽  
E. D. Thomas ◽  
J. Hersman ◽  
J. E. Sanders ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Marrow Transplant ◽  
Infectious Complications ◽  
Transplant Recipients ◽  
Prophylactic Measures ◽  
Allogeneic Marrow

scholarly journals Foscarnet for prevention of cytomegalovirus infection in allogeneic marrow transplant recipients unable to receive ganciclovir

1997 ◽  
Vol 20 (6) ◽  
pp. 491-495 ◽  
Author(s):  
C Ippoliti ◽  
A Morgan ◽  
D Warkentin ◽  
K van Besien ◽  
R Mehra ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Marrow Transplant ◽  
Transplant Recipients ◽  
To Receive ◽  
Allogeneic Marrow

scholarly journals Transfusion support using filtered unscreened blood products for cytomegalovirus-negative allogeneic marrow transplant recipients

1998 ◽  
Vol 22 (6) ◽  
pp. 575-577 ◽  
Author(s):  
AB Narvios ◽  
D Przepiorka ◽  
J Tarrand ◽  
K-W Chan ◽  
R Champlin ◽  
...  
Keyword(s):  
Marrow Transplant ◽  
Transplant Recipients ◽  
Blood Products ◽  
Allogeneic Marrow

scholarly journals Neutropenia in Allogeneic Marrow Transplant Recipients Receiving Ganciclovir for Prevention of Cytomegalovirus Disease: Risk Factors and Outcome

Blood ◽  
1997 ◽  
Vol 90 (6) ◽  
pp. 2502-2508 ◽  
Author(s):  
Bernd Salzberger ◽  
Raleigh A. Bowden ◽  
Robert C. Hackman ◽  
Chris Davis ◽  
Michael Boeckh
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Serum Creatinine ◽  
Elevated Serum ◽  
Significant Risk ◽  
Marrow Transplant ◽  
Transplant Recipients ◽  
Elevated Serum Creatinine ◽  
Marrow Cellularity ◽  
Allogeneic Marrow

Abstract To determine risk factors, frequency, time patterns, and outcome of ganciclovir-related neutropenia in allogeneic marrow transplant recipients, 278 consecutive patients receiving ganciclovir from engraftment until day 100 were studied. In this cohort, 159 patients (57%) had absolute neutrophil counts (ANC) less than 1,500/μL, 112 (41%) had an ANC less than 1,000/μL, 87 (31%) less than 750/μL, and 56 (21%) less than 500/μL for at least 2 consecutive days. Statistically significant risk factors for neutropenia in a Cox model were low marrow cellularity between day 21 and 28 (relative risk [RR] 2.4, P = .0002), hyperbilirubinemia ≥6 mg/dL during the first 20 days (RR 2.5, P = .0001), and elevation of serum creatinine ≥2 mg/dL after day 21 after transplant (RR 2.1, P = .001). Restriction to factors present at engraftment resulted in a similar model with low marrow cellularity, hyperbilirubinemia ≥6 mg/dL, and elevated serum creatinine as significant risk factors. Patients with no risk factor had an incidence of neutropenia of 21%, an incidence of 31% for one risk factor, and of 57% for two or more risk factors (RR 3.8, P = .001). Neutropenia was a negative predictor of overall (RR 2.0, P = .0001) and event-free survival (RR 2.1, P < .0001), and a predictor of relapse (RR 1.7, P = .03) and nonrelapse mortality (RR 2.1, P = .003). Thus, early liver dysfunction, elevated serum creatinine, and low marrow cellularity are risk factors for ganciclovir-related neutropenia. Neutropenia in ganciclovir recipients after marrow transplantation is an independent risk factor for mortality.

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