Viral etiology of leukemia

1962 ◽  
Vol 8 (6) ◽  
pp. 321-325 ◽  
Author(s):  
Ludwik Gross
Keyword(s):  
2008 ◽  
Vol 8 (2) ◽  
pp. 76-87 ◽  
Author(s):  
Melanie Cebioglu ◽  
Hans Schild ◽  
Olga Golubnitschaja

1989 ◽  
Vol 140 (3) ◽  
pp. 634-637 ◽  
Author(s):  
Maria M. Avila ◽  
Guadalupe Carballal ◽  
Hugo Rovaletti ◽  
Beatriz Ebekian ◽  
Marcos Cusminsky ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Cheng Lei ◽  
Lisong Yang ◽  
Cheong Tat Lou ◽  
Fan Yang ◽  
Kin Ian SiTou ◽  
...  

Abstract Background Acute respiratory infections (ARIs) are among the leading causes of hospitalization in children. Understanding the local dominant viral etiologies is important to inform infection control practices and clinical management. This study aimed to investigate the viral etiology and epidemiology of respiratory infections among pediatric inpatients in Macao. Methods A retrospective study using electronic health records between 2014 and 2017 at Kiang Wu Hospital was performed. Nasopharyngeal swab specimens were obtained from hospitalized children aged 13 years or younger with respiratory tract diseases. xMAP multiplex assays were employed to detect respiratory agents including 10 respiratory viruses. Data were analyzed to describe the frequency and seasonality. Results Of the 4880 children enrolled in the study, 3767 (77.1%) were positive for at least one of the 13 viral pathogens tested, of which 2707 (55.5%) being male and 2635 (70.0%) under 2 years old. Among the positive results, there were 3091 (82.0%) single infections and 676 (18.0%) multiple infections. The predominant viruses included human rhinovirus/enterovirus (HRV/EV 27.4%), adenovirus (ADV, 15.8%), respiratory syncytial virus B (RSVB, 7.8%) and respiratory syncytial virus A (RSVA, 7.8%). The detection of viral infection was the most prevalent in autumn (960/1176, 81.6%), followed by spring (1095/1406, 77.9%), winter (768/992, 77.4%), and summer (944/1306, 72.3%), with HRV/EV and ADV being most commonly detected throughout the 4 years of study period. The detection rate of viral infection was highest among ARI patients presented with croup (123/141, 87.2%), followed by lower respiratory tract infection (1924/2356, 81.7%) and upper respiratory tract infection (1720/2383, 72.2%). FluA, FluB and ADV were positive factors for upper respiratory tract infections. On the other hand, infection with RSVA, RSVB, PIV3, PIV4, HMPV, and EV/RHV were positively associated with lower respiratory tract infections; and PIV1, PIV2, and PIV3 were positively associated with croup. Conclusions This is the first study in Macao to determine the viral etiology and epidemiology of pediatric patients hospitalized for ARIs. The study findings can contribute to the awareness of pathogen, appropriate preventative measure, accurate diagnosis, and proper clinical management of respiratory viral infections among children in Macao.


2021 ◽  
pp. 104063872110357
Author(s):  
Margherita Orlandi ◽  
Maurizio Mazzei ◽  
Marta Vascellari ◽  
Erica Melchiotti ◽  
Claudia Zanardello ◽  
...  

Numerous canine papillomaviruses (CPVs) have been identified (CPV1–23). CPV1, 2, and 6 have been associated with inverted papillomas (IPs). We retrieved 19 IPs from 3 histopathology archives, and evaluated and scored koilocytes, inclusion bodies, giant keratohyalin granules, cytoplasmic pallor, ballooning degeneration, and parakeratosis. IHC targeting major capsid proteins of PV was performed, and CPV genotyping was achieved by PCR testing. Tissue localization of CPV DNA and RNA was studied by chromogenic and RNAscope in situ hybridization (DNA-CISH, RNA-ISH, respectively). IPs were localized to the limbs (50%), trunk (30%), and head (20%), mainly as single nodules (16 of 19). In 15 of 19 cases, immunopositivity was detected within the nuclei in corneal and subcorneal epidermal layers. PCR revealed CPV1 in 11 IPs and CPV2 DNA in 3 IPs. Overall, 14 of 17 cases were positive by both DNA-CISH and RNA-ISH, in accord with PCR results. A histologic score >5 was always obtained in cases in which the viral etiology was demonstrated by IHC, DNA-CISH, and RNA-ISH. IHC and molecular approaches were useful to ascertain the viral etiology of IPs. Although IHC is the first choice for diagnostic purposes, ISH testing allows identification of PV type and the infection phase. RNA-ISH seems a promising tool to deepen our understanding of the pathogenesis of different PV types in animal species.


Science ◽  
1990 ◽  
Vol 249 (4968) ◽  
pp. 466-466
Author(s):  
Jack W. Shields
Keyword(s):  

2021 ◽  
Author(s):  
Moran Amit ◽  
Gautam Mehta ◽  
Frederico G. Netto ◽  
Diana Bell ◽  
Deborah A. Silverman ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39523 ◽  
Author(s):  
Kari Hemminki ◽  
Richard Houlston ◽  
Jan Sundquist ◽  
Kristina Sundquist ◽  
Xiaochen Shu

2018 ◽  
Vol 52 ◽  
pp. 136-140 ◽  
Author(s):  
Syed Hani Abidi ◽  
Fareena Bilwani ◽  
Kulsoom Ghias ◽  
Farhat Abbas

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