Hemodynamically “insignificant” stenoses stimulate neointimal thickening in experimental vein grafts

2011 ◽  
Vol 10 (02) ◽  
pp. 92-95
Author(s):  
Shari Meyerson ◽  
Daniel Refai ◽  
Christopher Skelly ◽  
Michael Curi ◽  
Seymour Glagov ◽  
...  
Keyword(s):  
Vein Grafts ◽  
Neointimal Thickening

Hemodynamically ``Insignificant'' Stenoses Stimulate Neointimal Thickening in Experimental Vein Grafts

2001 ◽  
Vol 10 (2) ◽  
pp. 92-95
Author(s):  
Shari L. Meyerson ◽  
Daniel Refai ◽  
Christopher L. Skelly ◽  
Michael A. Curi ◽  
Seymour Glagov ◽  
...  
Keyword(s):  
Vein Grafts ◽  
Neointimal Thickening

Slower Onset of Low Shear Stress Leads to Less Neointimal Thickening in Experimental Vein Grafts

2006 ◽  
Vol 20 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Zachary K. Baldwin ◽  
Amito Chandiwal ◽  
Wendy Huang ◽  
James E. Vosicky ◽  
Viji Balasubramanian ◽  
...  
Keyword(s):  
Shear Stress ◽  
Vein Grafts ◽  
Neointimal Thickening ◽  
Low Shear Stress ◽  
Low Shear

Control of Autogenous Vein Grafts Prior to Reimplantation, By Electron Microscopy

1972 ◽  
Vol 30 ◽  
pp. 106-107
Author(s):  
John H. L. Watson ◽  
John L. Swedo ◽  
M. Vrandecic
Keyword(s):  
Electron Microscopy ◽  
Light And Electron Microscopy ◽  
Physiological Saline ◽  
Experimental Conditions ◽  
Vein Grafts ◽  
Arterial Blood ◽  
Saphenous Veins ◽  
Autogenous Vein ◽  
Control Of Parameters ◽  
Post Implantation

The ambient temperature and the nature of the storage fluids may well have significant effects upon the post-implantation behavior of venus autografts. A first step in the investigation of such effects is reported here. Experimental conditions have been set which approximate actual operating room procedures. Saphenous veins from dogs have been used as models in the experiments. After removal from the dogs the veins were kept for two hours under four different experimental conditions, viz at either 4°C or 23°C in either physiological saline or whole canine arterial blood. At the end of the two hours they were prepared for light and electron microscopy. Since no obvious changes or damage could be seen in the veins by light microscopy, even with the advantage of tissue specific stains, it was essential that the control of parameters for successful grafts be set by electron microscopy.

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