FR128998 (a PAF receptor antagonist) counters the increased pulmonary vascular resistance associated with ischemia-reperfusion injury in the canine lung

2011 ◽  
Vol 10 (01) ◽  
pp. 10-14 ◽  
Author(s):  
Shigeru Iwazaki ◽  
Izumi Takeyoshi ◽  
Susumu Ohwada ◽  
Yutaka Sunose ◽  
Masaaki Aiba ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Reperfusion Injury ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Paf Receptor ◽  
Paf Receptor Antagonist

Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance

1990 ◽  
Vol 69 (2) ◽  
pp. 597-603 ◽  
Author(s):  
R. C. Allison ◽  
J. Kyle ◽  
W. K. Adkins ◽  
V. R. Prasad ◽  
J. M. McCord ◽  
...  
Keyword(s):  
Blood Flow ◽  
Reperfusion Injury ◽  
Vascular Permeability ◽  
Vascular Resistance ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pulmonary Vascular Permeability ◽  
Permeability Changes ◽  
Lung Vascular Permeability ◽  
Hypoxia Reoxygenation

The effect of ischemia reperfusion or hypoxia reoxygenation on pulmonary vascular permeability and resistance was studied in 25 isolated blood-perfused dog lungs. Vascular permeability, assessed by determining filtration coefficient (Kf), and vascular resistances were measured at the beginning and end of the experiment. Ischemia reperfusion was produced by occluding blood flow to the lung for 3 h and reperfusing for 1 h, whereas hypoxia reoxygenation was obtained by ventilating the lung with 95% N2-5% CO2 for 3 h and then ventilating with 95% O2-5% CO2 for 1 h with no interruption of perfusion. There was a significant increase in Kf in both ischemia reperfusion and hypoxia reoxygenation groups (51 and 85%, respectively), and total vascular resistance increased greatly in both groups (386 and 532%, respectively). Two additional groups were also studied in which the ischemia reperfusion or hypoxia reoxygenation lungs were pretreated with allopurinol (20 micrograms/ml). The Kf did not significantly increase in either the allopurinol ischemia reperfusion or the allopurinol hypoxia reoxygenation groups (22 and 6%, respectively). However, total vascular resistance significantly increased in both groups (239 and 224%, respectively). Although vascular permeability is modestly increased by both ischemia reperfusion and hypoxia reoxygenation, the predominant change in these conditions is the increased vascular resistance, which predominantly affects the postcapillary resistance and would result in a greater tendency for edema to develop in these slightly damaged lungs. Allopurinol, which inhibits xanthine oxidase, attenuated the permeability changes in both groups and may be useful in preventing ischemia reperfusion injury in certain conditions.

ADENOSINE A1 RECEPTOR ANTAGONIST ATTENUATES ISCHEMIA-REPERFUSION INJURY OF THE LIVER

1999 ◽  
Vol 67 (7) ◽  
pp. S36
Author(s):  
Shinichiro Magata ◽  
Masahiko Taniguchi ◽  
Tomomi Suzuki ◽  
Tsuyoshi Shimamura ◽  
Maeng Bong Jin ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor

CV-11974, angiotensin II type I receptor antagonist, protects against ischemia–reperfusion injury of the small intestine in rats

2006 ◽  
Vol 535 (1-3) ◽  
pp. 283-290 ◽  
Author(s):  
Tomohisa Takagi ◽  
Norimasa Yoshida ◽  
Yutaka Isozaki ◽  
Makoto Shimozawa ◽  
Kazuhiro Katada ◽  
...  
Keyword(s):  
Small Intestine ◽  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Type I
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