Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: Developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia

1993 ◽  
Vol 423 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Kazushige Dobashi ◽  
Kohtaro Asayama ◽  
Hidemasa Hayashibe ◽  
Afreen Munim ◽  
Akira Kawaoi ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Newborn Infants ◽  
Hyaline Membrane Disease ◽  
Superoxide Dismutases ◽  
Human Fetuses ◽  
Developmental Profile ◽  
Manganese Superoxide ◽  
Hyaline Membrane ◽  
Copper Zinc ◽  
Manganese Superoxide Dismutases

scholarly journals Immunohistochemical localization of copper-zinc and manganese superoxide dismutases in rat tissues.

1989 ◽  
Vol 22 (3) ◽  
pp. 351-365 ◽  
Author(s):  
KAZUSHIGE DOBASHI ◽  
KOHTARO ASAYAMA ◽  
KIYOHIKO KATO ◽  
MAKIO KOBAYASHI ◽  
AKIRA KAWAOI
Keyword(s):  
Immunohistochemical Localization ◽  
Superoxide Dismutases ◽  
Rat Tissues ◽  
Manganese Superoxide ◽  
Copper Zinc ◽  
Manganese Superoxide Dismutases

THE BLOOD PRESSURE OF NEWBORN INFANTS IN ASPHYXIAL STATES AND IN HYALINE MEMBRANE DISEASE

PEDIATRICS ◽  
1960 ◽  
Vol 26 (5) ◽  
pp. 735-744
Author(s):  
Gerald A. Neligan ◽  
D. M. Oxon. ◽  
Clement A. Smith
Keyword(s):  
Initial Level ◽  
Newborn Infants ◽  
Systolic Pressure ◽  
Hyaline Membrane Disease ◽  
Elective Cesarean Section ◽  
Maternal Illness ◽  
Direct Measurements ◽  
Hyaline Membrane ◽  
Elective Cesarean ◽  
Blood Pressures

The early changes in the systolic blood pressures in six clinical groups of newborn infants have been studied. Readings of the sphygmomanometer used have been compared with "direct" measurements during cardiac catheterization, and the results are reported. In 36 normal mature infants the systolic pressure fell by a mean of 25 mm Hg from the initial value recorded within the first 5 minutes after delivery, to the lowest value, reached as a rule between 1 and 4 hours after delivery. In 18 clinically asphyxiated mature infants, the mean fall (38.5 mm Hg) was significantlygreater because the initial level was significantly higher (by 15.1 mm Hg) than the comparable initial level in the infants who breathed promptly. Three episodes of apnea during anesthesia have also been observed in two infants aged less than 48 hours, and on each occasion there has been an abrupt rise in the systolic pressure, with or without a corresponding bradycardia. In a group of premature infants studied from within the first half-hour after delivery, the seven of them diagnosed as hyaline membrane disease had a significant hypotension between 5 minutes and 4 hours after birth, as compared with the lowest systolic pressures found at corresponding times in the 10 infants who remained well. Among infants of diabetic mothers, a similar relative hypotension was observed in the four severe cases of hyaline membrane disease as compared with blood pressures of the 11 who remained well and the three who were mildly affected. A group of 13 mature infants delivered by elective cesarean section, for indications other than maternal illness of any kind, showed no significant differences in the course of their lowest systolic pressures as compared with the group of mature infants delivered from below. Neither the cause nor the significance of the hypotension seen in hyaline membrane disease is yet sufficiently clear to allow recommendation as to treatment.

Early-Onset Haemophilus Sepsis in Newborn Infants: Clinical, Roentgenographic, and Pathologic Features

PEDIATRICS ◽  
1978 ◽  
Vol 62 (3) ◽  
pp. 299-303
Author(s):  
Lawrence D. Lilien ◽  
Tsu F. Yeh ◽  
Gertrude M. Novak ◽  
Norman M. Jacobs
Keyword(s):  
Early Onset ◽  
Polymorphonuclear Leukocytes ◽  
Newborn Infants ◽  
Arterial Oxygen Tension ◽  
Hyaline Membrane Disease ◽  
Arterial Oxygen ◽  
Pathologic Features ◽  
High Incidence ◽  
Hyaline Membrane ◽  
Time Of Infection

Nine infants with early-onset Haemophilus sepsis were seen between January 1973 and July 1977. Of the five isolated strains that were typed, only one was type B. All infants had respiratory distress, metabolic acidosis, and large alveolar-arterial oxygen tension difference gradients. Eight infants weighed less than 1,500 gm and died; one infant weighed 1,701 gm and survived. Roentgenograms in six of eight showed hyaline membrane disease. Pulmonary pathologic specimens in eight infants revealed hyaline membranes in six and polymorphonuclear leukocytes in the alveolar spaces in four. In two infants, small Gram-negative bacilli were noted within proteinaceous exudates in alveolar ducts. The route and time of infection in these infants with early-onset Haemophilus sepsis are unclear. However, the possibility that the infection occurs before birth and that these infants represent septically aborted prematures is suggested by the high incidence of prematurity in infants with early-onset Haemophilus sepsis and early detection of bacteremia in three infants.

THE ADRENAL CORTEX, STEROIDS, AND HYALINE MEMBRANE DISEASE

PEDIATRICS ◽  
1971 ◽  
Vol 47 (4) ◽  
pp. 645-646
Author(s):  
John W. Reynolds
Keyword(s):  
Adrenal Cortex ◽  
Adrenal Glands ◽  
Direct Evidence ◽  
Matched Control ◽  
Newborn Infants ◽  
Hyaline Membrane Disease ◽  
Type Ii ◽  
Hyaline Membrane ◽  
Issue Reports ◽  
Number Of Cells

The paper by Naeye, et al.,1 in this issue reports a very interesting relation between adrenal gland size and the presence of hyaline membrane disease in newborn infants. Those infants with hyaline membrane disease had smaller adrenal glands than weight matched control infants, due to a decreased number of cells in both the permanent and fetal zones of the adrenal cortex. More direct evidence of possible relation between adrenal cortical size and the capacity of the lung to produce surfactant is brought out by their finding of a correlation between adrenal cortical size in anencephalic infants and the osmiophilic granule content of so-called type II alveolar lining cells.

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