Low glucose-6-phosphate dehydrogenase activity and increased sensitivity to paraquat toxicity

1980 ◽  
Vol 24 (1) ◽  
pp. 369-373 ◽  
Author(s):  
Edward J. Calabrese ◽  
Gary S. Moore ◽  
Soon-Ching Ho
Keyword(s):  
Dehydrogenase Activity ◽  
Paraquat Toxicity ◽  
Increased Sensitivity ◽  
Low Glucose ◽  
Glucose 6 Phosphate Dehydrogenase

Physiological control of alkylsulfatase synthesis in Pseudomonas aeruginosa: effects of glucose, glucose analogs, and sulfur

1977 ◽  
Vol 23 (10) ◽  
pp. 1456-1464 ◽  
Author(s):  
J. W. Fitzgerald ◽  
Lynda C. Kight
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Dehydrogenase Activity ◽  
Glucose Transport ◽  
Parent Strain ◽  
Sodium Sulfide ◽  
Inhibitory Effects ◽  
Physiological Control ◽  
Marked Enhancement ◽  
Low Glucose ◽  
Glucose 6 Phosphate Dehydrogenase

Pseudomonas aeruginosa (isolated from soil) synthesizes an alkylsulfatase allowing this bacterium to utilize sodium hexan-1-yl sulfate as a source of carbon and sulfur for growth. The formation of the enzyme was induced by this and by other (C4–C16) primary alkylsulfate esters as well as by some (C-8 and C-9) primary alkylsulfonates. Secondary (2-yl) alkylsulfate esters did not act as inducers. The induction of alkylsulfatase was markedly inhibited by L-cysteine, L-methionine, sodium sulfide, and by high (>2 mM) concentrations of D-glucose and other related monosaccharides. Similar inhibitory effects by four glucose analogs which will not support growth suggest that prior metabolism was not a requirement for glucose-mediated inhibition. The inhibition by D-glucose of the same inducible system in P. aeruginosa (PAO-57) supported this conclusion since this glucose transport-positive mutant is deficient in the further metabolism of the monosaccharide. At low (0.1–1.0 mM) concentrations, D-glucose or D-glucose 6-O-phosphate (20 mM) caused a marked enhancement of alkylsulfatase induction in the isolate. This novel enhancement was reproduced using P. aeruginosa strain PAO. However, both monosaccharides acted as potent inhibitors of alkylsulfatase formation occurring in mutant PAO-57 which, unlike the parent strain PAO, exhibits low glucose-6-phosphate dehydrogenase activity. These results suggest that D-glucose (0.1–1.0 mM) must be metabolized to enhance the synthesis of the enzyme.

Low Glucose-6-Phosphate Dehydrogenase Activity in Cultured Skin Fibroblasts from Werner's Syndrome

1986 ◽  
Vol 13 (5) ◽  
pp. 396-398 ◽  
Author(s):  
Yasuko Shindo ◽  
Junichi Akiyama ◽  
Kazuhiko Matsumoto ◽  
Yoshio Takase ◽  
Takashi Hashimoto
Keyword(s):  
Dehydrogenase Activity ◽  
Skin Fibroblasts ◽  
Werner’S Syndrome ◽  
Cultured Skin ◽  
Werner's Syndrome ◽  
Low Glucose ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Poor Prognosis in Nasopharyngeal Cancer Patients with Low Glucose-6-phosphate-dehydrogenase Activity

2001 ◽  
Vol 92 (5) ◽  
pp. 576-581 ◽  
Author(s):  
Ann-Joy Cheng ◽  
Daniel Tsun-Yee Chiu ◽  
Lai-Chu See ◽  
Chun-Ta Liao ◽  
I-How Chen ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Dehydrogenase Activity ◽  
Poor Prognosis ◽  
Nasopharyngeal Cancer ◽  
Low Glucose ◽  
Glucose 6 Phosphate Dehydrogenase

ACUTE ENZYME HISTOCHEMICAL CHANGES IN THE ZONA GLOMERULOSA OF THE RAT ADRENAL CORTEX

1968 ◽  
Vol 59 (3) ◽  
pp. 508-518
Author(s):  
J. D. Elema ◽  
M. J. Hardonk ◽  
Joh, Koudstaal ◽  
A. Arends
Keyword(s):  
Peritoneal Dialysis ◽  
Succinate Dehydrogenase ◽  
Dehydrogenase Activity ◽  
Adrenal Cortex ◽  
Isocitrate Dehydrogenase ◽  
Hydroxysteroid Dehydrogenase ◽  
Zona Glomerulosa ◽  
Acute Changes ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Histochemical Changes

ABSTRACT Acute changes in glucose-6-phosphate dehydrogenase and isocitrate dehydrogenase activity in the zona glomerulosa of the rat adrenal cortex were induced by peritoneal dialysis with 5 % glucose. Although less clear, the activity of 3β-ol-hydroxysteroid dehydrogenase also seemed to increase as well. No changes were seen in the activity of succinate dehydrogenase. Dialysis with 0.9 % NaCl had no effect on any of the enzymes investigated. The possible significance of these observations is discussed.

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