Motor nerve conduction velocity (MCV) and lead content in sciatic nerve of lead-exposed rats

1986 ◽  
Vol 37 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Naoki Maehara ◽  
Eiji Uchino ◽  
Kazuyuki Terayama ◽  
Hideki Ohno ◽  
Kohtaroh Yamamura
Keyword(s):  
Sciatic Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Lead Content ◽  
Motor Nerve Conduction

scholarly journals Effect of Treating Streptozotocin-Induced Diabetic Rats With Sorbinil, Myo-Inositol or Aminoguanidine on Endoneurial Blood Flow, Motor Nerve Conduction Velocity and Vascular Function of Epineurial Arterioles of the Sciatic Nerve

2002 ◽  
Vol 3 (1) ◽  
pp. 21-36 ◽  
Author(s):  
Lawrence J. Coppey ◽  
Jill S. Gellett ◽  
Eric P. Davidson ◽  
Joyce A. Dunlap ◽  
Mark A. Yorek
Keyword(s):  
Blood Flow ◽  
Sciatic Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Diabetic Rats ◽  
Motor Nerve Conduction Velocity ◽  
Motor Nerve Conduction ◽  
Endoneurial Blood Flow

Previously we have demonstrated that diabetes causes impairment in vascular function of epineurial vessels, which precedes the slowing of motor nerve conduction velocity. Treatment of diabetic rats with aldose reductase inhibitors, aminoguanidine or myo-inositol supplementation have been shown to improve motor nerve conduction velocity and/or decreased endoneurial blood flow. However, the effect these treatments have on vascular reactivity of epineurial vessels of the sciatic nerve is unknown. In these studies we examined the effect of treating streptozotocin-induced rats with sorbinil, aminoguanidine or myo-inositol on motor nerve conduction velocity, endoneurial blood flow and endothelium dependent vascular relaxation of arterioles that provide circulation to the region of the sciatic nerve. Treating diabetic rats with sorbinil, aminoguanidine or myo-inositol improved the reduction of endoneurial blood flow and motor nerve conduction velocity. However, only sorbinil treatment significantly improved the diabetes-induced impairment of acetylcholinemediated vasodilation of epineurial vessels of the sciatic nerve. All three treatments were efficacious in preventing the appropriate metabolic derangements associated with either activation of the polyol pathway or increased nonenzymatic glycation. In addition, sorbinil was shown to prevent the diabetes-induced decrease in lens glutathione level. However, other markers of oxidative stress were not vividly improved by these treatments. These studies suggest that sorbinil treatment may be more effective in preventing neural dysfunction in diabetes than either aminoguanidine or myoinositol.

scholarly journals Slowing of Motor Nerve Conduction Velocity in Streptozotocin-induced Diabetic Rats is Preceded by Impaired Vasodilation in Arterioles that Overlie the Sciatic Nerve

2000 ◽  
Vol 1 (2) ◽  
pp. 131-143 ◽  
Author(s):  
Lawrence J. Coppey ◽  
Eric P. Davidson ◽  
Joyce A. Dunlap ◽  
Donald D. Lund ◽  
Mark A. Yorek
Keyword(s):  
Blood Flow ◽  
Sciatic Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Vascular Function ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Diabetic Rat ◽  
Motor Nerve Conduction

Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat impaired vasodilator function in arterioles that provide circulation to the region of the sciatic nerve is associated with reduced endoneural blood flow (EBF) and that these defects precede slowing of motor nerve conduction velocity, and thereby may contribute to nerve dysfunction. As early as three days after the induction of diabetes endoneural blood flow was reduced in the STZ-induced diabetic rat. Furthermore, after 1 week of diabetes acetylcholine-induced vasodilation was found to be impaired. This was accompanied by an increase in the superoxide level in arterioles that provide circulation to the region of the sciatic nerve as well as changes in the level of other markers of oxidative stress including an increase in serum levels of thiobarbituric acid reactive substances and a decrease in lens glutathione level. In contrast to the vascular related changes that occur within 1 week of diabetes, motor nerve conduction velocity and sciatic nerveNa+/k+ATPase activity were significantly reduced following 2 and 4 weeks of diabetes, respectively. These studies demonstrate that changes in vascular function in the STZ-induced diabetic rat precede the slowing of motor nerve conduction velocity (MNCV) and are accompanied by an increase in superoxide levels in arterioles that provide circulation to the region of the sciatic nerve.

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