Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumours: An assessment of growth potential

1993 ◽  
Vol 422 (6) ◽  
pp. 481-486 ◽  
Author(s):  
Lianjia Yang ◽  
Kouji Hashimura ◽  
Chunlin Qin ◽  
Prashanta Shrestha ◽  
Sinichiro Sumitomo ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Proliferating Cell Nuclear Antigen ◽  
Growth Potential ◽  
Nuclear Antigen ◽  
Salivary Gland Tumours ◽  
Proliferating Cell

The evaluation of salivary gland tumours using proliferating cell nuclear antigen

1997 ◽  
Vol 111 (6) ◽  
pp. 551-555 ◽  
Author(s):  
N. J. Trendell-Smith ◽  
J. Oates ◽  
J. Crocker
Keyword(s):  
Salivary Gland ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Positive Control ◽  
Negative Control ◽  
Anaplastic Carcinoma ◽  
Nuclear Antigen ◽  
Salivary Gland Tumours ◽  
Normal Salivary Gland ◽  
Proliferating Cell

AbstractIn order to assess its discriminating and prognostic value, we studied the immunoreactivity for proliferating cell nuclear antigen (PCNA) in tissue from 52 human salivary gland tumours using the murine monoclonal antibody PC10.The PCNA percentage count, namely, the average number of positive nuclei counted per 100 randomly selected tumour cells was recorded for each tumour. Anaplastic carcinoma was used as a positive control and histologically ‘normal’ salivary gland and tonsil served as a negative control.A PCNA count of 30 per cent was postulated to predict malignancy within a given salivary gland tumour i.e. a PCNA count of 30 per cent or above would indicate malignant potential. This gave a sensitivity of 96.9 per cent and a specificity of 95.2 per cent and a positive predictive value of determining malignancy of 96.8 per cent.We conclude that PCNA immunoreactivity is useful in discriminating between benign and malignant salivary gland tumours and that it may have prognostic value in this diverse group of neoplasms.

scholarly journals Proliferating cell nuclear antigen(PCNA) as a marker of proliferating cells in salivary gland tumors.

1992 ◽  
Vol 34 (4) ◽  
pp. 454-457 ◽  
Author(s):  
Ikuko Ogawa ◽  
Takashi Takata ◽  
Mutsumi Miyauchi ◽  
Hiroshi Ito ◽  
Naokuni Ijuhin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Proliferating Cell Nuclear Antigen ◽  
Salivary Gland Tumors ◽  
Nuclear Antigen ◽  
Proliferating Cells ◽  
Proliferating Cell

scholarly journals Proliferating cell nuclear antigen antibody testing – getting them all

Pathology ◽  
2021 ◽  
Vol 53 ◽  
pp. S47
Author(s):  
Christine Bundell ◽  
Mathew Krummenacher ◽  
Elina Tan ◽  
Paul Sjollema ◽  
Nick Acquarola ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Antibody Testing ◽  
Antigen Antibody ◽  
Proliferating Cell
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