The immune response of inbred mouse strains to DNP-BGG

1977 ◽  
Vol 4 (1) ◽  
pp. 449-462 ◽  
Author(s):  
Robert C. Newton ◽  
Carol M. Warner
Keyword(s):  
Immune Response ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains

scholarly journals ANTIBODY RESPONSE OF INBRED MOUSE STRAINS TO ORDERED TETRAPEPTIDES OF TYROSINE AND GLUTAMIC ACID ATTACHED TO MULTICHAIN POLYALANINE OR POLYPROLINE

1974 ◽  
Vol 140 (2) ◽  
pp. 349-355 ◽  
Author(s):  
Edna Mozes ◽  
Michal Schwartz ◽  
Michael Sela
Keyword(s):  
Immune Response ◽  
Glutamic Acid ◽  
Inbred Mouse ◽  
Cross Reactivity ◽  
Antigenic Determinants ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Linked Gene ◽  
Random Peptide ◽  
Synthetic Polypeptide

Five inbred mouse strains which represent high and low responders to the random synthetic polypeptide poly(LTyr,LGlu)-polyDLAla--polyLLys, designated (T, G)-A--L, to which the immune response is controlled by an H-2-linked gene, were immunized with three ordered tetrapeptides composed of tyrosine and glutamic acid attached either to multichain poly-DL-alanine or to polyproline. Only one of the three antigenic determinants, namely tyrosyl-tyrosyl-glytamyl-glutamic acid (T-T-G-G), resembled the random peptide (T, G) in the pattern of immune responses elicited against it, and in the cross-reactivity of the specific antibodies with (T, G)-A--L. The immune response pattern to the other two ordered tetrapeptides, T-G-T-G and G-T-T-G, was different from that obtained with (T, G)-A--L, and no cross-reactivity was detected between the antibodies provoked with these peptides and (T, G)-A--L. Thus, it is suggested that T-T-G-G is a major determinant in the random (T, G)-A--L.

scholarly journals CLONAL NATURE OF THE IMMUNE RESPONSE TO PHOSPHORYLCHOLINE

1974 ◽  
Vol 140 (3) ◽  
pp. 673-686 ◽  
Author(s):  
J. Latham Claflin ◽  
Joseph M. Davie
Keyword(s):  
Immune Response ◽  
Binding Site ◽  
Inbred Mouse ◽  
Binding Specificity ◽  
Rodent Species ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Myeloma Protein ◽  
Clonal Nature ◽  
Different Strains

A new idiotypic determinant(s) on mouse anti-PC antibodies is described. Antibodies to the determinant(s) were raised in rabbits by immunization with HOPC 8, a PC-binding myeloma protein, and were isolated from HOPC 8 immunoadsorbent by elution with PC. These antibodies react with binding site determinants on anti-PC antibodies raised in all 15 inbred mouse strains tested regardless of histocompatibility or allotype, but fail to react with antibodies of other specificities or with anti-PC antibodies raised in other rodent species. These results correlate closely with other studies which show similar binding specificity of anti-PC antibodies raised in 17 different strains of mice. The site-associated idiotypic determinant(s) is clearly distinct from that detected by mouse anti-HOPC 8 antisera. This latter determinant(s) is present on anti-PC antibodies of only a few strains of mice and may not be in the binding site.

scholarly journals THE Ah PHENOTYPE. SURVEY OF FORTY-EIGHT RAT STRAINS AND TWENTY INBRED MOUSE STRAINS

Genetics ◽  
1982 ◽  
Vol 100 (1) ◽  
pp. 79-87
Author(s):  
Daniel W Nebert ◽  
Nancy M Jensen ◽  
Hisashi Shinozuka ◽  
Heinz W Kunz ◽  
Thomas J Gill
Keyword(s):  
Specific Activity ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Mouse Strains ◽  
Ah Receptor ◽  
Inbred Mouse Strains ◽  
Sprague Dawley ◽  
Rat Strains ◽  
Specific Activities ◽  
Inbred Rat

ABSTRACT Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.

scholarly journals Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains

1999 ◽  
Vol 40 (2) ◽  
pp. 295-301 ◽  
Author(s):  
John J. Albers ◽  
Wendy Pitman ◽  
Gertrud Wolfbauer ◽  
Marian C. Cheung ◽  
Hal Kennedy ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Phospholipid Transfer Protein ◽  
Inbred Mouse Strains ◽  
Protein Activity ◽  
Transfer Protein ◽  
Phospholipid Transfer

scholarly journals Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

2012 ◽  
Vol 13 (1) ◽  
pp. 94 ◽  
Author(s):  
Holger Hackstein ◽  
Andreas Wachtendorf ◽  
Sabine Kranz ◽  
Jürgen Lohmeyer ◽  
Gregor Bein ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Dendritic Cell Subsets ◽  
Lymphocyte Populations
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