The effects of temperature on the blocking action of methyisopropoxyflurophosphine oxide (Soman) of the propagated action potential of the bullfrog sciatic nerve

1971 ◽  
Vol 6 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Ernest R. Whitcomb
Keyword(s):  
Sciatic Nerve ◽  
Action Potential ◽  
Effects Of Temperature

Changes in Crossed Spinal Reflexes After Peripheral Nerve Injury and Repair

2002 ◽  
Vol 87 (4) ◽  
pp. 1763-1771 ◽  
Author(s):  
Antoni Valero-Cabré ◽  
Xavier Navarro
Keyword(s):  
Sciatic Nerve ◽  
Action Potential ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Tibialis Anterior ◽  
Tibial Nerve ◽  
Spinal Reflexes ◽  
Injury And Repair

We investigated the changes induced in crossed extensor reflex responses after peripheral nerve injury and repair in the rat. Adults rats were submitted to non repaired sciatic nerve crush (CRH, n = 9), section repaired by either aligned epineurial suture (CS, n = 11) or silicone tube (SIL4, n = 13), and 8 mm resection repaired by tubulization (SIL8, n = 12). To assess reinnervation, the sciatic nerve was stimulated proximal to the injury site, and the evoked compound muscle action potential (M and H waves) from tibialis anterior and plantar muscles and nerve action potential (CNAP) from the tibial nerve and the 4th digital nerve were recorded at monthly intervals for 3 mo postoperation. Nociceptive reinnervation to the hindpaw was also assessed by plantar algesimetry. Crossed extensor reflexes were evoked by stimulation of the tibial nerve at the ankle and recorded from the contralateral tibialis anterior muscle. Reinnervation of the hindpaw increased progressively with time during the 3 mo after lesion. The degree of muscle and sensory target reinnervation was dependent on the severity of the injury and the nerve gap created. The crossed extensor reflex consisted of three bursts of activity (C1, C2, and C3) of gradually longer latency, lower amplitude, and higher threshold in control rats. During follow-up after sciatic nerve injury, all animals in the operated groups showed recovery of components C1 and C2 and of the reflex H wave, whereas component C3 was detected in a significantly lower proportion of animals in groups with tube repair. The maximal amplitude of components C1 and C2 recovered to values higher than preoperative values, reaching final levels between 150 and 245% at the end of the follow-up in groups CRH, CS, and SIL4. When reflex amplitude was normalized by the CNAP amplitude of the regenerated tibial nerve, components C1 (300–400%) and C2 (150–350%) showed highly increased responses, while C3 was similar to baseline levels. In conclusion, reflexes mediated by myelinated sensory afferents showed, after nerve injuries, a higher degree of facilitation than those mediated by unmyelinated fibers. These changes tended to decline toward baseline values with progressive reinnervation but still remained significant 3 mo after injury.

Effect of High-Intensity X-Radiation on the A Group Fibers of the Frog's Sciatic Nerve

1956 ◽  
Vol 184 (2) ◽  
pp. 333-337 ◽  
Author(s):  
Herbert B. Gerstner
Keyword(s):  
Sciatic Nerve ◽  
Ionizing Radiation ◽  
Action Potential ◽  
Rise Time ◽  
High Intensity ◽  
Dose Range ◽  
Monophasic Action Potential ◽  
Potential Amplitude ◽  
Complete Failure ◽  
Sciatic Nerves

Isolated sciatic nerves of bullfrogs received x-radiation at a dose rate of 9 kr/min. Prior to and following exposure, the monophasic action potential was recorded. In alpha fibers, doses between 75 kr and 200 kr caused a decrease in conduction velocity, an increase in the rise time of the action potential, and an elevated rheobase with shortened chronaxie; the potential amplitude was not obviously affected. In the dose range above 200 kr, the potential amplitude declined rapidly and complete failure of function occurred at about 300 kr. Beta fibers closely resembled alpha fibers in behavior; however, they appeared to be somewhat more radioresistant than a portion of the alpha subdivision. Gamma fibers seemed to be most susceptible to ionizing radiation; their potential disappeared at doses between 150 kr and 200 kr.

Effects of Static Magnetic Field on Compound Action Potential of Isolated Frog Sciatic Nerve

2019 ◽  
Vol 24 (4) ◽  
pp. 668-673
Author(s):  
Serkan Cizmeciogullari ◽  
Yasar Keskin ◽  
N. Hale Saybasili ◽  
Selcuk Paker
Keyword(s):  
Magnetic Field ◽  
Sciatic Nerve ◽  
Action Potential ◽  
Static Magnetic Field ◽  
Compound Action Potential ◽  
Frog Sciatic Nerve ◽  
Compound Action

scholarly journals THE INFLUENCE OF HIGH HYDROSTATIC PRESSURE ON COCAINE AND VERATRINE ACTION IN A VERTEBRATE NERVE

1959 ◽  
Vol 42 (3) ◽  
pp. 647-653 ◽  
Author(s):  
Norman L. Gershfeld ◽  
Abraham M. Shanes
Keyword(s):  
High Pressure ◽  
Hydrostatic Pressure ◽  
Sciatic Nerve ◽  
Action Potential ◽  
High Hydrostatic Pressure ◽  
Elevated Pressure

The application of high hydrostatic pressure to toad sciatic nerve causes a gain in sodium and a loss of potassium which are not affected by cocaine. However, cocaine action is enhanced by high pressure when counteracting veratrine depolarization and when blocking the action potential. Various effects of elevated pressure on the after-potentials are presented and the role of ions in these processes is discussed.

THE EFFECT OF BUPIVACAINE ON COMPOUND ACTION POTENTIAL PARAMETERS OF SCIATIC NERVE FIBERS

2004 ◽  
Vol 114 (1) ◽  
pp. 1-16 ◽  
Author(s):  
NIZAMETTIN DALKILIC ◽  
HULAGU BARISKANER ◽  
NECDET DOGAN ◽  
ILHAMI DEMIREL ◽  
BARKIN ILHAN
Keyword(s):  
Sciatic Nerve ◽  
Action Potential ◽  
Compound Action Potential ◽  
Nerve Fibers ◽  
Potential Parameters ◽  
Compound Action
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