Observation and study of a narrow state in a? ?(1,385)K + system

1984 ◽  
Vol 25 (3) ◽  
pp. 205-212 ◽  
Author(s):  
A. N. Aleev ◽  
V. A. Arefiev ◽  
V. P. Balandin ◽  
V. K. Birulev ◽  
A. S. Chvyrov ◽  
...  
Keyword(s):  
Narrow State

scholarly journals Negative Cooperativity between Gemin2 and RNA provides Insights into RNA Selection and the SMN Complex’s Release in snRNP Assembly

2018 ◽  
Author(s):  
Hongfei Yi ◽  
Li Mu ◽  
Congcong Shen ◽  
Xi Kong ◽  
Yingzhi Wang ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Basic Mechanism ◽  
Negative Cooperativity ◽  
Sm Proteins ◽  
Early Step ◽  
Smn Complex ◽  
Narrow State ◽  
Snrnp Core

ABSTRACTThe assembly of snRNP cores, in which seven Sm proteins, D1/D2/F/E/G/D3/B, form a ring around the nonameric Sm site of snRNAs, is the early step of spliceosome formation and essential to eukaryotes. It is mediated by the PMRT5 and SMN complexes sequentially in vivo. SMN deficiency causes neurodegenerative disease spinal muscular atrophy (SMA). How the SMN complex assembles snRNP cores is largely unknown, especially how the SMN complex achieves high RNA assembly specificity and how it is released. Here we show, using crystallographic and biochemical approaches, that Gemin2 of the SMN complex enhances RNA specificity of SmD1/D2/F/E/G via a negative cooperativity between Gemin2 and RNA in binding SmD1/D2/F/E/G. Gemin2, independent of its N-tail, constrains the horseshoe-shaped SmD1/D2/F/E/G from outside in a physiologically relevant, narrow state, enabling high RNA specificity. Moreover, the assembly of RNAs inside widens SmD1/D2/F/E/G, causes the release of Gemin2/SMN allosterically and allows SmD3/B to join. The assembly of SmD3/B further facilitates the release of Gemin2/SMN. This is the first to show negative cooperativity in snRNP assembly, which provides insights into RNA selection and the SMN complex’s release. These findings reveal a basic mechanism of snRNP core assembly and facilitate pathogenesis studies of SMA.

scholarly journals Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly

2019 ◽  
Vol 48 (2) ◽  
pp. 895-911 ◽  
Author(s):  
Hongfei Yi ◽  
Li Mu ◽  
Congcong Shen ◽  
Xi Kong ◽  
Yingzhi Wang ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Basic Mechanism ◽  
Negative Cooperativity ◽  
Sm Proteins ◽  
Early Step ◽  
Smn Complex ◽  
Narrow State ◽  
Snrnp Core

Abstract The assembly of snRNP cores, in which seven Sm proteins, D1/D2/F/E/G/D3/B, form a ring around the nonameric Sm site of snRNAs, is the early step of spliceosome formation and essential to eukaryotes. It is mediated by the PMRT5 and SMN complexes sequentially in vivo. SMN deficiency causes neurodegenerative disease spinal muscular atrophy (SMA). How the SMN complex assembles snRNP cores is largely unknown, especially how the SMN complex achieves high RNA assembly specificity and how it is released. Here we show, using crystallographic and biochemical approaches, that Gemin2 of the SMN complex enhances RNA specificity of SmD1/D2/F/E/G via a negative cooperativity between Gemin2 and RNA in binding SmD1/D2/F/E/G. Gemin2, independent of its N-tail, constrains the horseshoe-shaped SmD1/D2/F/E/G from outside in a physiologically relevant, narrow state, enabling high RNA specificity. Moreover, the assembly of RNAs inside widens SmD1/D2/F/E/G, causes the release of Gemin2/SMN allosterically and allows SmD3/B to join. The assembly of SmD3/B further facilitates the release of Gemin2/SMN. This is the first to show negative cooperativity in snRNP assembly, which provides insights into RNA selection and the SMN complex's release. These findings reveal a basic mechanism of snRNP core assembly and facilitate pathogenesis studies of SMA.

Narrative Pasts

2020 ◽  
Author(s):  
Jyoti Gulati Balachandran
Keyword(s):  
South Asia ◽  
Social History ◽  
Indian Subcontinent ◽  
Western Indian Ocean ◽  
The Social ◽  
Commercial World ◽  
History Of ◽  
Narrow State ◽  
Indian Ocean World ◽  
Literary Materials

Narrative Pasts explores the narrative power of texts—genealogical, historical, and biographical—in creating communities. It retrieves the social history of a Muslim community in Gujarat, a region that has one of the earliest records of Muslim presence in the Indian subcontinent. By reconstructing the literary, social, and historical world of Sufi preceptors, disciples, and descendants from the fifteenth to the seventeenth century, the book reveals the importance of learned Muslim men in imparting a distinct regional and historical identity to Gujarat. The prominence of Gujarat’s maritime location has often oriented the study of Gujarat towards the commercial world of the western Indian Ocean world. Narrative Pasts demonstrates that Gujarat was also an integral part of the historical and narrative processes that shaped medieval and early modern South Asia. Employing new and rarely used literary materials in Persian and Arabic, this book departs from the narrow state-centred visions of the Muslim past and integrates Gujarat’s sultanate and Mughal past with the larger socio-cultural histories of Islamic South Asia.

Globalizing Education in Times of Hyper-Nationalism, Rising Authoritarianism, and Shrinking Worldviews

2020 ◽  
Vol 14 (1) ◽  
pp. 47-68
Author(s):  
Eve Darian-Smith
Keyword(s):  
Liberal Education ◽  
Liberal Arts ◽  
The United States ◽  
Global Studies ◽  
Global Knowledge ◽  
The World ◽  
Narrow State ◽  
Colonial Histories ◽  
Core Mission ◽  
Epistemological Pluralism

AbstractWith the global political tide pushing increasingly narrow state-framed worldviews there is a retrenchment of how people understand their relational place in, and connection to, the world. This essay argues that precisely because of the rise of hyper-nationalism (and accompanying anti-democratic trends) there is an urgent need to pursue the globalizing of public education and the coproduction of global knowledge more generally. I suggest that the emerging field of Global Studies, which has been gaining ground in the United States and even more so around the world in recent decades, offers a pedagogical pathway to promoting critical interdisciplinary perspectives and fostering equality and respect for others. My basic claim is that Global Studies shares with liberal education a core mission to promote peace in a world of cultural diversity. But in calling for epistemological pluralism – and highlighting the American (western) epistemological underpinnings of the liberal arts that are deeply implicated in colonial histories of racism, oppression and silencing of non-western knowledge – Global Studies also highlights the inherent limitations of liberal education that as a new field of inquiry it seeks to overcome.

scholarly journals Meson spectroscopy at VES and COMPASS

2019 ◽  
Vol 212 ◽  
pp. 03010 ◽  
Author(s):  
Dmitry Ryabchikov
Keyword(s):  
Detailed Comparison ◽  
Partial Wave Analysis ◽  
Final States ◽  
Wave Analysis ◽  
Decay Channels ◽  
Diffractive Production ◽  
Meson Spectroscopy ◽  
Narrow State ◽  
The Subject ◽  
Mass Dependent

Diffractive production of π- π- π+ and π- π0 π0 final states is the subject of comprehensive studies performed recently by the VES and the COM-PASS experiments. COMPASS pioneered the application of novel methods of partial-wave analysis: mass-independent PWA inmultiple (m3π, t’)-cells, mass-dependent analysis of spin-density matrices performed simultaneously in all measured t’ bins, the analysis with freed shapes of π+ π- isobars. In addition, COMPASS observed a new narrow state: a1(1420). VES has world-leading data samples on π- π- π+ and π- π0 π0, that yield compatible results and show the potential for a detailed comparison of isospin relations between different decay channels, using the PWA methods with fixed and freed shapes of ππ isobars.

scholarly journals Observation of a Narrow State Decaying intoΞc+π−

1995 ◽  
Vol 75 (24) ◽  
pp. 4364-4368 ◽  
Author(s):  
P. Avery ◽  
A. Freyberger ◽  
K. Lingel ◽  
C. Prescott ◽  
J. Rodriguez ◽  
...  
Keyword(s):  
Narrow State

THE DISCOVERY OF TWO NEW SURPRISING Ds STATES

2004 ◽  
Vol 19 (18) ◽  
pp. 1327-1339
Author(s):  
ANTIMO PALANO
Keyword(s):  
Mass Spectrum ◽  
Invariant Mass ◽  
Mass Distribution ◽  
Invariant Mass Distribution ◽  
B Decays ◽  
Potential Models ◽  
New States ◽  
State Formula ◽  
Narrow State ◽  
Babar Experiment

The BaBar experiment has discovered an unexpected new narrow state, [Formula: see text] in the inclusive [Formula: see text] invariant mass distribution from e+e- annihilation data at energies near 10.6 GeV. The same experiment has also shown evidence for structure in the 2.46 GeV c2 region in the [Formula: see text] mass spectrum. These discoveries have triggered a search in several experiments for new states coupled to the [Formula: see text] meson which have confirmed the existence of [Formula: see text] together with [Formula: see text] both in inclusive e+e- annihilation and in B-decays. These two new states are difficult to explain in terms of potential models.

New evidence for a narrow state of mass 2.02 GeV/c2

1993 ◽  
Vol 558 ◽  
pp. 191-200 ◽  
Author(s):  
A. Ferrer ◽  
A.A. Grigoryan ◽  
V.F. Perepelitsa ◽  
P. Sonderegger
Keyword(s):  
Narrow State ◽  
New Evidence

scholarly journals Pentaquark symmetries, selection rules and another potentially narrow state

2004 ◽  
Vol 586 (1-2) ◽  
pp. 75-82 ◽  
Author(s):  
F.E. Close ◽  
J.J. Dudek
Keyword(s):  
Selection Rules ◽  
Narrow State
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