Neonatal lupus erythematosus with cardiac involvement in offspring of mothers with experimental systemic lupus erythematosus

1994 ◽  
Vol 14 (5) ◽  
pp. 314-322 ◽  
Author(s):  
Francis Kalush ◽  
Ephraim Rimon ◽  
Allex Keller ◽  
Edna Mozes
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cardiac Involvement ◽  
Systemic Lupus ◽  
Neonatal Lupus ◽  
Neonatal Lupus Erythematosus ◽  
Experimental Systemic Lupus Erythematosus

scholarly journals SLICC 2012: Kriteria Klasifikasi SLE

2019 ◽  
Vol 2 (2) ◽  
pp. 48-59
Author(s):  
Prema Hapsari Handayani
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Disease ◽  
Discoid Lupus Erythematosus ◽  
Systemic Lupus ◽  
Neonatal Lupus ◽  
Drug Induced ◽  
Neonatal Lupus Erythematosus

Istilah Lupus diambil dari bahasa latin yang berarti serigala dan dipakai pertama kali pada abad pertengahan untuk menggambarkan lesi kulit yang erosive yang mirip dengan gigitan serigala. Pada tahun 1846 seorang ahli  dari Vienna bernama Ferdinand von Hebra memperkenalkan istilah “kupu-kupu” untuk menggambarkan rash di daerah malar dan menyebutnya sebagai lupus erythematosus . Ilustrasi ini dipublikasikan pertama kali dalam bukunya berjudul Atlas os Skin Disease pada tahun 1856.  Lupus kemudian dibagi menjadi tiga bentuk, yaitu Discoid Lupus Erythematosus,Neonatal Lupus Erythematosus, Drug Induced Lupus dan Systemic Lupus Erythematosus.

Сase of neonatal lupus in one of two children of dichorial diamniotic pregnancy in a woman with unrecognized systemic lupus erythematosus and lupus nephritis

2020 ◽  
Vol 24 (2) ◽  
pp. 88-95
Author(s):  
T. V. Kirsanova ◽  
N. F. Kravchenko ◽  
A. I. Balakireva
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Treatment Options ◽  
Interdisciplinary Approach ◽  
Reproductive Function ◽  
Modern Medicine ◽  
Systemic Lupus ◽  
Neonatal Lupus ◽  
Neonatal Lupus Erythematosus ◽  
Management Approaches

The ability to realize the reproductive function for both patients with systemic lupus erythematosus and patients with a different cause of chronic kidney disease is rightfully considered as one of the most important achievements of modern medicine. The work describes the pregnancy case of the patient with systemic lupus erythematosus and secondary antiphospholipid syndrome. Renal damage with the development of renal thrombotic microangiopathy came to the fore in the clinical picture, which was regarded as nephritis and complicated the diagnosis of systemic lupus erythematosus. A positive pregnancy outcome was achieved with the development of neonatal lupus erythematosus in one twin child. The options for the prevention and treatment of thrombotic complications as well as methods for minimizing gestational complications (including preeclampsia, which the patient had in history) are discussed, inter alia, with the purposed of low-molecular-weight heparins and acetylsalicylic acid preparations. Treatment options are also described to improve the outcome of such pregnancies and to decrease the symptoms of neonatal lupus erythematosus using hydroxychloroquine. The article summarizes current management approaches for these patients with special attention to the interdisciplinary approach.

scholarly journals Cardiac involvement in systemic lupus erythematosus not only limited to pericarditis

2011 ◽  
Vol 11 (5) ◽  
pp. 507.2-507
Author(s):  
Pankaj Garg ◽  
Reza Ashrafi ◽  
Ewan McKay ◽  
Gershan Davis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cardiac Involvement ◽  
Systemic Lupus

scholarly journals Neonatal Lupus and Complete Atrioventricular Block: Case Report in Mexico

2021 ◽  
pp. 1-7
Author(s):  
Carla Eugenia Arenas Alvarez ◽  
Juan Carlos Marin Mireles ◽  
Hebert Israel Flores Leal ◽  
Ana Norma Griselda Becerril Gonzalez ◽  
Carlos Mario Guzman Sanchez
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Gestational Age ◽  
Lupus Erythematosus ◽  
Fetal Echocardiography ◽  
Fetal Mortality ◽  
Complete Atrioventricular Block ◽  
Systemic Lupus ◽  
Neonatal Lupus ◽  
Complete Atrioventricular

Aims: To describe a case of neonatal lupus and complete atrioventricular block in Mexico. Presentation of case: A 38 years old pregnant patient at  28 + 6 weeks of gestational age, diagnosed with systemic lupus erythematosus six years ago, under treatment with hydroxychloroquine and prednisone, this was suspended eight months prior to pregnancy; and resumed at week 20 of gestational age. The ultrasound scan showed alive fetus, female, polyhydramnios and bradycardia. Fetal echocardiography confirmed complete atrioventricular block, without organic and structural alterations at the cardiac level. Furthermore, the immunological panel reports, positive anti-Ro antibodies. At week 33 of gestational age, the patient was admitted to the obstetric emergency room, through colic type pain and 4 cm dilation of the cervix. Alive newborn got vaginally with a weight of 1,990 g, a height of 43 cm and APGAR 8-9. Echocardiography confirmed congenital complete third degree atrioventricular block; without structural abnormalities. Discussion: Patients with systemic lupus erythematosus, are more likely to have complications during pregnancy. Neonatal lupus is a rare disorder with an incidence of 1:10,000 - 1:20,000 newborns. This is caused by the transplacental passage of maternal autoantibodies anti-SSA / Ro and/or anti-SSB / La. Besides Atrioventricular block is a complication of neonatal lupus, occurring in approximately 2% of newborns of mothers who have SSA or SSB antibodies. The most interesting finding is that 20% fetal mortality has been for this cause. Conclusion: The described case is important for its rarity. Besides, the imaging findings and immunological panel emphasized the relevance about complete and adequate evaluation of the fetus, in the context of a mother with systemic lupus erythematosus.

SYSTEMIC LUPUS ERYTHEMATOSUS

PEDIATRICS ◽  
1960 ◽  
Vol 26 (4) ◽  
pp. 570-585
Author(s):  
Charles D. Cook ◽  
Ralph J. P. Wedgwood ◽  
John M. Craig ◽  
John R. Hartmann ◽  
Charles A. Janeway
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Failure ◽  
Lupus Erythematosus ◽  
Clinical Evidence ◽  
Cardiac Involvement ◽  
Disease Process ◽  
Symptomatic Improvement ◽  
Complete Disappearance ◽  
Systemic Lupus ◽  
Urinary Abnormalities

An analysis of 37 cases of systemic lupus erythematosus in children is reported in order to demonstrate the course of this disease and its pathology. In this series 92% of the children were girls. Necropsies of 14 cases of the present series revealed characteristic renal findings in all, even when clinical evidence of renal disease had been absent. Generalized arteriolitis as well as evidence of cardiac involvement was usually present. Renal failure was the most frequent cause of death. Of the 37 children, 10 were alive at the time of this report; 8 of these surviving patients have been followed for more than 2 years. Steroid therapy was associated with partial or complete disappearance of urinary abnormalities in six children. Endocrine therapy was used in 32 of the children with symptomatic improvement in most cases. Until more specific drugs are available, an intensive and prolonged course of therapy with adrenal corticosteroids offers the best, though limited, chance of slowing or halting this disease process.

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