Threonyl-tRNA synthetase gene maps close to leucyl-tRNA synthetase gene on human chromosome 5

1986 ◽  
Vol 12 (5) ◽  
pp. 519-522 ◽  
Author(s):  
Steven C. Gerken ◽  
John J. Wasmuth ◽  
Stuart M. Arfin
Keyword(s):  
Human Chromosome ◽  
Trna Synthetase ◽  
Chromosome 5 ◽  
Gene Maps ◽  
Human Chromosome 5

Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5

1982 ◽  
Vol 2 (10) ◽  
pp. 1220-1228
Author(s):  
S Dana ◽  
J J Wasmuth
Keyword(s):  
Human Chromosome ◽  
Mammalian Species ◽  
Chinese Hamster ◽  
Trna Synthetase ◽  
Gene Organization ◽  
Deletion Mapping ◽  
Chromosome 2 ◽  
Chromosome 5 ◽  
Human Chromosome 5 ◽  
Chinese Hamster Chromosome

Chinese hamster-human interspecific hybrid cells, which contain human chromosome 5 and express four genes linked on that chromosome, were subjected to selective conditions requiring them to retain one of the four linked genes, leuS (encoding leucyl-tRNA synthetase), but lose another, either emtB (encoding ribosomal protein S14) or chr. Cytogenetic and biochemical analyses of spontaneous segregants isolated by using these unique selective pressures have enabled us to determine the order and regional location of the leuS, hexB, emtB, and chr genes on human chromosome 5. These segregants arise primarily by terminal deletions of various portions of the long arm of chromosome 5. Our results indicate that the order of at least three of these genes is the same on human chromosome 5 and Chinese hamster chromosome 2. Thus, there appears to be extensive homology between Chinese hamster chromosome 2 and human chromosome 5, which represents an extreme example of the conservation of gene organization between very divergent mammalian species. In addition, these hybrids and selective conditions provide a very simple and quantitative means to assess the potency of various agents suspected of inducing gross chromosomal damage.

scholarly journals Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.

1982 ◽  
Vol 2 (10) ◽  
pp. 1220-1228 ◽  
Author(s):  
S Dana ◽  
J J Wasmuth
Keyword(s):  
Human Chromosome ◽  
Mammalian Species ◽  
Chinese Hamster ◽  
Trna Synthetase ◽  
Gene Organization ◽  
Deletion Mapping ◽  
Chromosome 2 ◽  
Chromosome 5 ◽  
Human Chromosome 5 ◽  
Chinese Hamster Chromosome

Chinese hamster-human interspecific hybrid cells, which contain human chromosome 5 and express four genes linked on that chromosome, were subjected to selective conditions requiring them to retain one of the four linked genes, leuS (encoding leucyl-tRNA synthetase), but lose another, either emtB (encoding ribosomal protein S14) or chr. Cytogenetic and biochemical analyses of spontaneous segregants isolated by using these unique selective pressures have enabled us to determine the order and regional location of the leuS, hexB, emtB, and chr genes on human chromosome 5. These segregants arise primarily by terminal deletions of various portions of the long arm of chromosome 5. Our results indicate that the order of at least three of these genes is the same on human chromosome 5 and Chinese hamster chromosome 2. Thus, there appears to be extensive homology between Chinese hamster chromosome 2 and human chromosome 5, which represents an extreme example of the conservation of gene organization between very divergent mammalian species. In addition, these hybrids and selective conditions provide a very simple and quantitative means to assess the potency of various agents suspected of inducing gross chromosomal damage.

Backfoot, a Novel Homeobox Gene, Maps to Human Chromosome 5 (BFT) and Mouse Chromosome 13 (Bft)

Genomics ◽  
1997 ◽  
Vol 40 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Jin Shang ◽  
Xu Li ◽  
Huijun Z. Ring ◽  
David A. Clayton ◽  
Uta Francke
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Homeobox Gene ◽  
Chromosome 5 ◽  
Chromosome 13 ◽  
Gene Maps ◽  
Human Chromosome 5

scholarly journals The gene coding for the p68 calcium-binding protein is localised to bands q32?q34 of human chromosome 5, and to mouse chromosome 11

1989 ◽  
Vol 82 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Adelina A. Davies ◽  
Stephen E. Moss ◽  
Mark R. Crompton ◽  
Tania A. Jones ◽  
Nigel K. Spurr ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Chromosome 11 ◽  
Chromosome 5 ◽  
Gene Coding ◽  
Mouse Chromosome 11 ◽  
Human Chromosome 5

Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5

1994 ◽  
Vol 67 (2) ◽  
pp. 69-74 ◽  
Author(s):  
S.K. Loftus ◽  
R. Shiang ◽  
J.A. Warrington ◽  
U. Bengtsson ◽  
J.D. McPherson ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Adrenergic Receptors ◽  
Chromosome 5 ◽  
Genes Encoding ◽  
Human Chromosome 5

IL9 maps to mouse chromosome 13 and human chromosome 5

1990 ◽  
Vol 31 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Beverly A. Mock ◽  
Marianne Krall ◽  
Christine A. Kozak ◽  
Muriel N. Nesbitt ◽  
O. Wesley McBride ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 5 ◽  
Chromosome 13 ◽  
Human Chromosome 5
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