Assignment of human nerve growth factor receptor gene to chromosome 17 and regulation of receptor expression in somatic cell hybrids

1986 ◽  
Vol 12 (5) ◽  
pp. 441-447 ◽  
Author(s):  
Wolfgang J. Rettig ◽  
Timothy M. Thomson ◽  
Barbara A. Spengler ◽  
June L. Biedler ◽  
Lloyd J. Old
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Somatic Cell ◽  
Receptor Gene ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Chromosome 17 ◽  
Somatic Cell Hybrids ◽  
Nerve Growth ◽  
Human Nerve

scholarly journals Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues.

1988 ◽  
Vol 36 (4) ◽  
pp. 383-389 ◽  
Author(s):  
P G Chesa ◽  
W J Rettig ◽  
T M Thomson ◽  
L J Old ◽  
M R Melamed
Keyword(s):  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Normal Development ◽  
Malignant Tumors ◽  
Sympathetic Neurons ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Receptor Expression ◽  
Nerve Growth

Nerve growth factor (NGF) is a polypeptide important for normal development of the nervous system and promotion of survival and differentiation of sensory and sympathetic neurons in culture. The cellular effects of NGF are mediated by a specific cell surface molecule, nerve growth factor receptor (NGF-R). In the present study we have used a monoclonal antibody against human NGF-R to examine, by the avidin-biotin-immunoperoxidase method, the receptor distribution in a wide range of normal tissues and in more than 200 malignant tumors. Our results show that (a) human NGF-R is expressed in the peripheral nervous system but not in any of the central nervous system areas tested; (b) NGF-R expression is not restricted to neural tissues but is also found in a number of normal epithelial, mesenchymal, and lymphoid tissues; (c) NGF-R expression changes during normal development; and (d) NGF-R expression in malignant tumors generally parallels its normal tissue distribution. Thus, NGF-R is detected in a proportion of neuroectoderm-derived tumors, carcinomas, and lymphomas, and also in a characteristic group of small round-cell tumors (Ewing's sarcomas and embryonal rhabdomyosarcomas). These findings suggest a normal regulatory role for NGF in both neuronal and non-neuronal cells and identify a range of human tumors in which the NGF/NGF-R system may contribute to the malignant phenotype.

The T Cell Activation Molecule CD27 Is a Member of the Nerve Growth Factor Receptor Gene Family

1991 ◽  
pp. 131-145 ◽  
Author(s):  
Wil A. M. Loenen ◽  
Rolien de Jong ◽  
Loes A. Gravestein ◽  
René A. W. van Lier ◽  
Jannie Borst
Keyword(s):  
Nerve Growth Factor ◽  
T Cell ◽  
Growth Factor ◽  
Gene Family ◽  
T Cell Activation ◽  
Cell Activation ◽  
Receptor Gene ◽  
Growth Factor Receptor ◽  
Nerve Growth ◽  
Receptor Gene Family

Monoclonal antibodies against mouse nerve growth factor produced by somatic cell hybrids

1981 ◽  
Vol 6 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Rita Businaro ◽  
Richard H. Butler ◽  
Allan E. Rubenstein ◽  
Roberto P. Revoltella
Keyword(s):  
Monoclonal Antibodies ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Somatic Cell ◽  
Somatic Cell Hybrids ◽  
Nerve Growth ◽  
Cell Hybrids
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