Cell fusion-impaired variants of a mouse lymphocytic cell line obtained by single-step selection for polyethylene glycol resistance

1980 ◽  
Vol 6 (1) ◽  
pp. 127-137 ◽  
Author(s):  
J. Stadler ◽  
V. Vaughan ◽  
J. Hanser
Keyword(s):  
Polyethylene Glycol ◽  
Cell Line ◽  
Cell Fusion ◽  
Single Step ◽  
Lymphocytic Cell ◽  
Selection For ◽  
Step Selection ◽  
Lymphocytic Cell Line

Reduced pinosome formation in a cell-fusion-impaired mutant of mouse lymphocytic cell line L5178Y

1986 ◽  
Vol 126 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Peter G. Pauw ◽  
Karen G. Biagi ◽  
Joan K. Stadler
Keyword(s):  
Cell Line ◽  
Cell Fusion ◽  
Lymphocytic Cell ◽  
A Cell ◽  
Lymphocytic Cell Line

Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line

1989 ◽  
Vol 181 (1) ◽  
pp. 273-281 ◽  
Author(s):  
C. Legraverend ◽  
A. Potter ◽  
E. Hölttä ◽  
K. Alitalo ◽  
L.C. Andersson
Keyword(s):  
Cell Line ◽  
Ornithine Decarboxylase ◽  
Interleukin 2 ◽  
Lymphocytic Cell ◽  
Lymphocytic Cell Line

Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine

1984 ◽  
Vol 4 (7) ◽  
pp. 1231-1237
Author(s):  
N Bouck ◽  
D Kokkinakis ◽  
J Ostrowsky
Keyword(s):  
Cell Line ◽  
Cell Fusion ◽  
Somatic Mutation ◽  
Complementation Group ◽  
Single Step ◽  
Permanent Cell Line ◽  
Bhk Cells ◽  
Permanent Cell ◽  
A Cell

The permanent cell line BHK-21/cl 13 can be transformed by mutagenic carcinogens as the result of the induction of a recessive somatic mutation. Yet when these cells were treated with 5-azacytidine under conditions in which no mutants resistant to either ouabain or 6-thioguanine could be detected, they were transformed efficiently. These transformants were induced, not selected. 6-Azacytidine was ineffective at transforming BHK cells; 2'-deoxy-5-azacytidine was exceptionally effective. When tested by cell fusion, transformants induced by 5-azacytidine fell into the same complementation group as those induced by highly mutagenic carcinogens, but they were phenotypically distinct in that they were unstable during prolonged passage and rarely displayed the temperature-limited phenotypes so common among BHK transformants induced by strongly mutagenic carcinogens. These results raise the possibility that a cell can be induced by either genetic or epigenetic means to traverse the same single step in carcinogenesis.

B-lymphocytic cell line Raji expresses the leukotriene A4 hydrolase gene but not the 5-lipoxygenase gene

1989 ◽  
Vol 161 (2) ◽  
pp. 740-745 ◽  
Author(s):  
Juan F. Medina ◽  
Björn Odlander ◽  
Colin D. Funk ◽  
Ji-Yi Fu ◽  
Hans-Erik Claesson ◽  
...  
Keyword(s):  
Cell Line ◽  
Lymphocytic Cell ◽  
Leukotriene A4 Hydrolase ◽  
Lipoxygenase Gene ◽  
Leukotriene A4 ◽  
Lymphocytic Cell Line
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