Distribution of vasoactive intestinal polypeptide and substance P receptors in human colon and small intestine

1989 ◽  
Vol 34 (7) ◽  
pp. 1100-1108 ◽  
Author(s):  
Louis Y. Korman ◽  
Hassan Sayadi ◽  
Barbara Bass ◽  
Terry W. Moody ◽  
John W. Harmon
1979 ◽  
Vol 27 (9) ◽  
pp. 1283-1284 ◽  
Author(s):  
L I Larsson

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.


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