Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5

1988 ◽  
Vol 14 (5) ◽  
pp. 515-518 ◽  
Author(s):  
Fa-Ten Kao ◽  
Kun C. Wu ◽  
Martha L. Law ◽  
Judith A. Hartz ◽  
Yun-Fai Lau
Keyword(s):  
Lactate Dehydrogenase ◽  
Human Gene ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Lactate Dehydrogenase C

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

Gene ◽  
1993 ◽  
Vol 136 (1-2) ◽  
pp. 355-360 ◽  
Author(s):  
Brian F. O'Dowd ◽  
Michael Heiber ◽  
Audrey Chan ◽  
Henry H.Q. Heng ◽  
Lap-Chee Tsui ◽  
...  
Keyword(s):  
Human Gene ◽  
Angiotensin Receptor ◽  
Chromosome 11 ◽  
Gene Encoding

scholarly journals The ldhA Gene Encoding Fermentative L-Lactate Dehydrogenase in Corynebacterium glutamicum Is Positively Regulated by the Global Regulator GlxR

2021 ◽  
Vol 9 (3) ◽  
pp. 550
Author(s):  
Koichi Toyoda ◽  
Masayuki Inui
Keyword(s):  
Lactate Dehydrogenase ◽  
Binding Site ◽  
Corynebacterium Glutamicum ◽  
Lactate Production ◽  
Exponential Phase ◽  
Aerobic Bacterium ◽  
Global Regulator ◽  
Gene Encoding ◽  
Fermentation Products ◽  
Ldha Gene

Bacterial metabolism shifts from aerobic respiration to fermentation at the transition from exponential to stationary growth phases in response to limited oxygen availability. Corynebacterium glutamicum, a Gram-positive, facultative aerobic bacterium used for industrial amino acid production, excretes L-lactate, acetate, and succinate as fermentation products. The ldhA gene encoding L-lactate dehydrogenase is solely responsible for L-lactate production. Its expression is repressed at the exponential phase and prominently induced at the transition phase. ldhA is transcriptionally repressed by the sugar-phosphate-responsive regulator SugR and L-lactate-responsive regulator LldR. Although ldhA expression is derepressed even at the exponential phase in the sugR and lldR double deletion mutant, a further increase in its expression is still observed at the stationary phase, implicating the action of additional transcription regulators. In this study, involvement of the cAMP receptor protein-type global regulator GlxR in the regulation of ldhA expression was investigated. The GlxR-binding site found in the ldhA promoter was modified to inhibit or enhance binding of GlxR. The ldhA promoter activity and expression of ldhA were altered in proportion to the binding affinity of GlxR. Similarly, L-lactate production was also affected by the binding site modification. Thus, GlxR was demonstrated to act as a transcriptional activator of ldhA.

Association analysis of the Arg220His variation of the human gene encoding the GABA δ subunit with idiopathic generalized epilepsy

2005 ◽  
Vol 65 (1-2) ◽  
pp. 53-57 ◽  
Author(s):  
Kirsten P. Lenzen ◽  
Armin Heils ◽  
Susanne Lorenz ◽  
Anne Hempelmann ◽  
Thomas Sander
Keyword(s):  
Association Analysis ◽  
Human Gene ◽  
Idiopathic Generalized Epilepsy ◽  
Gene Encoding ◽  
Generalized Epilepsy

The Gene Encoding Protein Kinase SEK1 Maps to Mouse Chromosome 11 and Human Chromosome 17

Genomics ◽  
1996 ◽  
Vol 34 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Robert A. White ◽  
Rowland T. Hughes ◽  
Linda R. Adkison ◽  
Gail Bruns ◽  
Leonard I. Zon
Keyword(s):  
Protein Kinase ◽  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 17 ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Human Chromosome 17 ◽  
Mouse Chromosome 11 ◽  
Encoding Protein
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