Assignment of gene coding human T-cell differentiation antigen, Tpl20, to chromosome 11

1985 ◽  
Vol 11 (3) ◽  
pp. 217-222 ◽  
Author(s):  
Ikuya Tsuge ◽  
Kazuhiko R. Utsumi ◽  
Ryuzo Ueda ◽  
Shigeru Takamoto ◽  
Toshitada Takahashi
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Chromosome 11 ◽  
Differentiation Antigen ◽  
Human T Cell ◽  
Gene Coding

Amplification of a gene coding for human T-cell differentiation antigen

Nature ◽  
1983 ◽  
Vol 306 (5941) ◽  
pp. 385-387 ◽  
Author(s):  
Paula Kavathas ◽  
Leonard A. Herzenberg
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Differentiation Antigen ◽  
Human T Cell ◽  
Gene Coding

Molecular cloning of the gene coding for the human T cell differentiation antigen CD7

1991 ◽  
Vol 33 (5-6) ◽  
pp. 352-360 ◽  
Author(s):  
Kazuhiro Yoshikawa ◽  
Masao Seto ◽  
Ryuzo Ueda ◽  
Yuichi Obata ◽  
Kunihiro Notake ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Molecular Cloning ◽  
T Cell Differentiation ◽  
Differentiation Antigen ◽  
Human T Cell ◽  
Gene Coding

scholarly journals Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.

1985 ◽  
Vol 161 (2) ◽  
pp. 429-434 ◽  
Author(s):  
V P Sukhatme ◽  
A C Vollmer ◽  
J Erikson ◽  
M Isobe ◽  
C Croce ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Light Chain ◽  
T Cell Differentiation ◽  
Chromosome 8 ◽  
Kappa Light Chain ◽  
Chromosome 2 ◽  
Differentiation Antigen ◽  
Light Chain Gene ◽  
Human T Cell

We have mapped the gene encoding the T cell differentiation antigen Leu-2/T8 to human chromosome 2 by hybridization of a Leu-2/T8 complementary DNA clone to DNA from a panel of mouse-human cell hybrids. In situ hybridization further localizes the gene to the 2p1 region in close proximity to the Ig kappa light chain gene. The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen.

A new human T-cell differentiation antigen: Unexpected expression on chronic lymphocytic leukemia cells

1980 ◽  
Vol 11-11 (1) ◽  
pp. 429-439 ◽  
Author(s):  
Paul J. Martin ◽  
John A. Hansen ◽  
Robert C. Nowinski ◽  
Melissa A. Brown
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
T Cell Differentiation ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Differentiation Antigen ◽  
Human T Cell

scholarly journals An RFLP associated with pcDLen2–14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12

1986 ◽  
Vol 14 (19) ◽  
pp. 7817-7817 ◽  
Author(s):  
A.M. Bowcock ◽  
P. Kavathas ◽  
R. F. Margolskee ◽  
L. Herzenberg ◽  
L. L. Cavalli-Sforza
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Differentiation Antigen ◽  
Human T Cell

scholarly journals HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling

2020 ◽  
Vol 117 (24) ◽  
pp. 13740-13749 ◽  
Author(s):  
Yusuke Higuchi ◽  
Jun-ichirou Yasunaga ◽  
Yu Mitagami ◽  
Hirotake Tsukamoto ◽  
Kazutaka Nakashima ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Transgenic Mice ◽  
Regulatory T Cell ◽  
T Cell Differentiation ◽  
Cytokine Signaling ◽  
Viral Gene ◽  
Cell Leukemia Virus Type ◽  
Human T Cell

Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of a T cell neoplasm and several inflammatory diseases. A viral gene, HTLV-1 bZIP factor (HBZ), induces pathogenic Foxp3-expressing T cells and triggers systemic inflammation and T cell lymphoma in transgenic mice, indicating its significance in HTLV-1–associated diseases. Here we show that, unexpectedly, a proinflammatory cytokine, IL-6, counteracts HBZ-mediated pathogenesis. Loss of IL-6 accelerates inflammation and lymphomagenesis in HBZ transgenic mice. IL-6 innately inhibits regulatory T cell differentiation, suggesting that IL-6 functions as a suppressor against HBZ-associated complications. HBZ up-regulates expression of the immunosuppressive cytokine IL-10. IL-10 promotes T cell proliferation only in the presence of HBZ. As a mechanism of growth promotion by IL-10, HBZ interacts with STAT1 and STAT3 and modulates the IL-10/JAK/STAT signaling pathway. These findings suggest that HTLV-1 promotes the proliferation of infected T cells by hijacking the machinery of regulatory T cell differentiation. IL-10 induced by HBZ likely suppresses the host immune response and concurrently promotes the proliferation of HTLV-1 infected T cells.

scholarly journals Modulated expression of notch1 during thymocyte development

Blood ◽  
1996 ◽  
Vol 88 (3) ◽  
pp. 970-976 ◽  
Author(s):  
RP Hasserjian ◽  
JC Aster ◽  
F Davi ◽  
DS Weinberg ◽  
J Sklar
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Flow Cytometric Analysis ◽  
T Cell Differentiation ◽  
Thymocyte Development ◽  
Cd8 Cells ◽  
Flow Cytometric ◽  
Human T Cell ◽  
Weak Staining ◽  
Notch Gene

Abstract The Notch gene family encodes transmembrane proteins that have been implicated in control of diverse cellular differentiation events in the fly, frog, and mouse. Mammalian Notch1 is expressed at high levels in thymus and is mutated in a subset of human T-cell acute lymphoblastic neoplasms, suggesting a role in T-cell differentiation. To investigate the patterns of expression of NOTCH1 protein in thymocytes of the developing and mature thymus, antibodies raised against NOTCH1 were used to perform immunohistochemical and flow cytometric analyses. Strong staining for NOTCH1 within the fetal murine thymus was observed as early as 13.5 days postcoitum. By 17.5 days postcoitum, preferential staining of superficial cortical thymocytes was observed, with weak staining of developing medulla. Flow cytometric analysis and immunohistochemical staining of flow-sorted cells confirmed that the highest levels of NOTCH1 expression in adult murine thymus were present in immature cortical thymocytes (CD24high, CD4-CD8-). In contrast, NOTCH1 expression was low or absent in more mature cortical thymocytes (CD24low, CD4+CD8+), whereas intermediate levels of expression were observed in CD4+CD8- and CD4-CD8+ cells. These data indicate a dynamic pattern of NOTCH1 expression during T-cell differentiation and suggest that downregulation of NOTCH1 may be required for maturation of cortical thymocytes.

Human T Cell Differentiation: New Techniques, Old Challenges

2010 ◽  
pp. 351-371
Author(s):  
Jean Plum ◽  
Magda De Smedt ◽  
Georges Leclercq ◽  
Bart Vandekerckhove ◽  
Tom Taghon
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
New Techniques ◽  
Human T Cell
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