Role of macrophages in the host response to Lewis lung peritoneal carcinomatosis

1994 ◽  
Vol 38 (4) ◽  
pp. 233-242
Author(s):  
Malcolm W. Barth ◽  
Page S. Morahan
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Host Response ◽  
Lewis Lung

The role of peritoneal carcinomatosis index in the operative treatment of ovarian cancer

2018 ◽  
Vol 16 (2) ◽  
pp. 82-88
Author(s):  
Włodzimierz Sawicki ◽  
◽  
Nabil Abdalla ◽  
Krzysztof Cendrowski ◽  
◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peritoneal Carcinomatosis ◽  
Operative Treatment ◽  
Peritoneal Carcinomatosis Index

scholarly journals Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 766
Author(s):  
David F. Woods ◽  
Stephanie Flynn ◽  
Jose A. Caparrós-Martín ◽  
Stephen M. Stick ◽  
F. Jerry Reen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bile Acids ◽  
Host Response ◽  
Signal Molecules ◽  
Therapeutic Approaches ◽  
Related Factors ◽  
Host Interactions ◽  
Important Host ◽  
Respiratory Microbiota

The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis (CF). Understanding the microbial and host-related factors that govern the establishment of chronic CF lung inflammation and pathogen colonisation is essential. Specifically, dissecting the interplay in the inflammation–pathogen–host axis. Bile acids are important host derived and microbially modified signal molecules that have been detected in CF lungs. These bile acids are associated with inflammation and restructuring of the lung microbiota linked to chronicity. This community remodelling involves a switch in the lung microbiota from a high biodiversity/low pathogen state to a low biodiversity/pathogen-dominated state. Bile acids are particularly associated with the dominance of Proteobacterial pathogens. The ability of bile acids to impact directly on both the lung microbiota and the host response offers a unifying principle underpinning the pathogenesis of CF. The modulating role of bile acids in lung microbiota dysbiosis and inflammation could offer new potential targets for designing innovative therapeutic approaches for respiratory disease.

CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model

2001 ◽  
Vol 281 (5) ◽  
pp. L1303-L1311 ◽  
Author(s):  
Shan-Ze Wang ◽  
Cynthia L. Rosenberger ◽  
Teresa M. Espindola ◽  
Edward G. Barrett ◽  
Yohannes Tesfaigzi ◽  
...  
Keyword(s):  
Airway Epithelium ◽  
Host Response ◽  
Secretory Protein ◽  
Allergic Airway Disease ◽  
Clara Cell ◽  
Myeloperoxidase Activity ◽  
Wild Type ◽  
Airway Reactivity ◽  
Mucus Production

Clara cell secretory protein (CCSP) is synthesized by nonciliated bronchiolar cells in the lung and modulates lung inflammation to infection. To determine the role of CCSP in the host response to allergic airway disease, CCSP-deficient [(−/−)] mice were immunized twice with ovalbumin (Ova) and challenged by Ova (2 or 5 mg/m3) aerosol. After 2, 3, and 5 days of Ova aerosol challenge (6 h/day), airway reactivity was increased in CCSP(−/−) mice compared with wild-type [CCSP(+/+)] mice. Neutrophils were markedly increased in the bronchoalveolar lavage fluid of CCSP(−/−) Ova mice, coinciding with increased myeloperoxidase activity and macrophage inflammatory protein-2 levels. Lung histopathology and inflammation were increased in CCSP(−/−) compared with wild-type mice after Ova challenge. Mucus production, as assessed by histological staining, was increased in the airway epithelium of CCSP(−/−) Ova mice compared with that in CCSP(+/+) Ova mice. These data suggest a role for CCSP in airway reactivity and the host response to allergic airway inflammation and provide further evidence for the role of the airway epithelium in regulating airway responses in allergic disease.

scholarly journals Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection

2018 ◽  
Vol 12 (1) ◽  
pp. 223-231 ◽  
Author(s):  
Kari Ann Shirey ◽  
Mary E. Sunday ◽  
Wendy Lai ◽  
Mira C. Patel ◽  
Jorge C. G. Blanco ◽  
...  
Keyword(s):  
Host Response ◽  
Influenza Infection ◽  
Gastrin Releasing Peptide

Acute malignant obstruction in patients with peritoneal carcinomatosis: The role of palliative surgery

2019 ◽  
Vol 45 (3) ◽  
pp. 389-393 ◽  
Author(s):  
Nadine L. de Boer ◽  
Jan A.W. Hagemans ◽  
Bob T.A. Schultze ◽  
Alexandra R.M. Brandt-Kerkhof ◽  
Eva V.E. Madsen ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Palliative Surgery ◽  
Malignant Obstruction
Sign in / Sign up

Export Citation Format

Share Document