Inhibition of rat pleural mesothelial cell nitric oxide synthesis by transforming growth factor-β1

Inflammation ◽  
1996 ◽  
Vol 20 (6) ◽  
pp. 637-646 ◽  
Author(s):  
Michael W. Owens ◽  
Shawn A. Milligan ◽  
Matthew B. Grisham
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Mesothelial Cell ◽  
Transforming Growth Factor Β1 ◽  
Nitric Oxide Synthesis

scholarly journals Evidence for Control of Nitric Oxide Synthesis by Intracellular Transforming Growth Factor-β1 in Tumor Cells

1999 ◽  
Vol 154 (6) ◽  
pp. 1867-1876 ◽  
Author(s):  
Patricia Lagadec ◽  
Stéphane Raynal ◽  
Blandine Lieubeau ◽  
Nathalie Onier ◽  
Laurent Arnouldá ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Tumor Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Nitric Oxide Synthesis

scholarly journals Role of Transforming Growth Factor-β1 in Cardiovascular Inflammatory Changes Induced by Chronic Inhibition of Nitric Oxide Synthesis

Hypertension ◽  
2000 ◽  
Vol 35 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Masamichi Koyanagi ◽  
Kensuke Egashira ◽  
Mayuko Kubo-Inoue ◽  
Makoto Usui ◽  
Shiro Kitamoto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Nitric Oxide Synthesis ◽  
Inflammatory Changes

scholarly journals INFLUENCE OF CYTOKINES PRODUCTION, NITROGEN OXIDE METABOLITES AND LIPIDS EXCHANGE ON THE FORMATION OF EXTERNAL GENITAL ENDOMETRIOSIS STAGES IN PATIENTS OF REPRODUCTIVE AGE

2020 ◽  
Vol 17 (35) ◽  
pp. 813-824
Author(s):  
Natalya Victorovna ERMOLOVA ◽  
Yuriy Alekseevich PETROV ◽  
Marina Arkadevna LEVKOVICH ◽  
Ludmila Valerievna KOLESNIKOVA ◽  
Nina Aleksandrovna DRUKKER
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Young Patients ◽  
Reproductive Function ◽  
Transforming Growth Factor Β1 ◽  
Biologically Active ◽  
Reproductive Age ◽  
Nitric Oxide Metabolites ◽  
Factor Α

The relevance of the study is due to the prevalence and increase in the incidence of endometriosis, especially in young patients, its influence on reproductive function, and the lack of reliable non-invasive diagnosis of the disease and its stages. There are no unified views on the etiology and multifactorial pathogenesis of this disease. This article is aimed at revealing the mechanisms of the formation of endometriosis stages basing on the study of the effect of cytokines production, nitric oxide metabolites and lipid metabolism. The main approach to study this problem is both to investigate systemic (blood serum) and local (peritoneal fluid) levels, their comparison. This allows comprehensive consideration of the pathogenesis of the disease and determination of the value of the mentioned biologically active factors depending on the stages of the disease. The article presents new data on the content of high- and low-density lipoproteins, cholesterol, transforming growth factor β1 and tumor necrosis factor α, the content of nitric oxide metabolites and their clinical interpretation is given according to the stages of the disease. The materials of the article are of practical value for researchers of endometriosis and practicing obstetrician-gynecologists.. Keywords: external genital endometriosis, lipoproteins, nitric oxide, transforming growth factor.

Leukocyte recruitment in colon cancer: Role of cell adhesion molecules, nitric oxide, and transforming growth factor β1

2002 ◽  
Vol 122 (4) ◽  
pp. 1122-1132 ◽  
Author(s):  
Xavier Bessa ◽  
J.Ignasi Elizalde ◽  
Francesc Mitjans ◽  
Virgínia Piñol ◽  
Rosa Miquel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Colon Cancer ◽  
Cell Adhesion ◽  
Growth Factor ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Leukocyte Recruitment

Transforming growth factor-β1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways

2018 ◽  
Vol 96 (5) ◽  
pp. 527-534 ◽  
Author(s):  
Brice Ongali ◽  
Nektaria Nicolakakis ◽  
Xin-Kang Tong ◽  
Clotilde Lecrux ◽  
Hans Imboden ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Cerebrovascular Reactivity ◽  
Cerebrovascular Dysfunction ◽  
Tgf Β1

Transgenic mice constitutively overexpressing the cytokine transforming growth factor-β1 (TGF-β1) (TGF mice) display cerebrovascular alterations as seen in Alzheimer’s disease (AD) and vascular cognitive impairment and dementia (VCID), but no or only subtle cognitive deficits. TGF-β1 may exert part of its deleterious effects through interactions with angiotensin II (AngII) type 1 receptor (AT1R) signaling pathways. We test such interactions in the brain and cerebral vessels of TGF mice by measuring cerebrovascular reactivity, levels of protein markers of vascular fibrosis, nitric oxide synthase activity, astrogliosis, and mnemonic performance in mice treated (6 months) with the AT1R blocker losartan (10 mg/kg per day) or the angiotensin converting enzyme inhibitor enalapril (3 mg/kg per day). Both treatments restored the severely impaired cerebrovascular reactivity to acetylcholine, calcitonin gene-related peptide, endothelin-1, and the baseline availability of nitric oxide in aged TGF mice. Losartan, but not enalapril, significantly reduced astrogliosis and cerebrovascular levels of profibrotic protein connective tissue growth factor while raising levels of antifibrotic enzyme matrix metallopeptidase-9. Memory was unaffected by aging and treatments. The results suggest a pivotal role for AngII in TGF-β1-induced cerebrovascular dysfunction and neuroinflammation through AT1R-mediated mechanisms. Further, they suggest that AngII blockers could be appropriate against vasculopathies and astrogliosis associated with AD and VCID.

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