Role of cyclic AMP in the regulation of renin release from the isolated perfused rat kidney

1978 ◽  
Vol 56 (S1) ◽  
pp. 51-59 ◽  
Author(s):  
K. G. Hofbauer ◽  
A. Konrads ◽  
K. Schwarz ◽  
U. Werner
Keyword(s):  
Cyclic Amp ◽  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney

1990 ◽  
Vol 415 (6) ◽  
pp. 713-717 ◽  
Author(s):  
Rainer Nobiling ◽  
Klaus Münter ◽  
Christian P. Bührle ◽  
Eberhard Hackenthal
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Pulsatile Perfusion

Stimulation of renin release in perfused kidney by low calcium and high magnesium

1977 ◽  
Vol 232 (4) ◽  
pp. F377-F382 ◽  
Author(s):  
J. S. Fray
Keyword(s):  
Sodium Excretion ◽  
Calcium Concentration ◽  
Perfusion Pressure ◽  
Rat Kidney ◽  
Sodium Concentration ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Low Calcium ◽  
Perfused Rat Kidney ◽  
Stimulation Of

These experiments were designed to test whether changing perfusate calcium or magnesium concentrations affected renin release in the isolated perfused rat kidney, and whether kidneys removed from sodium-loaded or sodium-deprived rats released the same amount of renin in response to identical stimuli. Kidneys were perfused with Kreb-Henseleit solution containing albumin. Renin release was inversely related to perfusate calcium concentration, whereas renin release was directly related to perfusate magnesium. Although a low calcium medium or low perfusion pressure (50 mmHg) stimulated renin release, the release was substantially greater in the sodium-deprived rats. Increasing the perfusate sodium concentration from 85 to 206 mM increased excretion, but did not alter renin release. It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release.

Nitric oxide enhancement of erythropoietin production in the isolated perfused rat kidney

1995 ◽  
Vol 269 (4) ◽  
pp. C917-C922 ◽  
Author(s):  
K. Yoshioka ◽  
J. W. Fisher
Keyword(s):  
Nitric Oxide ◽  
Rat Kidney ◽  
Mrna Levels ◽  
Isolated Perfused Rat Kidney ◽  
Intracellular Cgmp ◽  
Perfused Rat Kidney ◽  
Arterial Po2

We have previously reported that nitric oxide (NO) and guanosine 3',5'-cyclic monophosphate (cGMP) may be involved in the regulation of erythropoietin (Epo) production in response to hypoxia both in vivo and in vitro (20). In the present studies, we have used the isolated perfused rat kidney to assess the role of NO in oxygen sensing and Epo production. When arterial PO2 was reduced from 100 mmHg (normoxemic) to 30 mmHg (hypoxemic) in the perfusate of this system, perfusate levels of Epo were significantly increased. This hypoxia-induced increase in Epo production was significantly decreased by the addition of NG-nitro-L-arginine methyl ester (L-NAME; 1 mM) to the perfusates. Hypoxemic perfusion also produced a significant increase, and L-NAME significantly inhibited this increase, in intracellular cGMP levels in the kidney when compared with normoxemic perfused kidneys. Quantitative reverse transcription-polymerase chain reaction also revealed that hypoxemic perfusion produced significant increases in Epo mRNA levels in the kidney, which was blocked by L-NAME. Our findings further support an important role for the NO/cGMP system in hypoxic regulation of Epo production.

scholarly journals Effects of atrial natriuretic peptide on renal function and renin release in the isolated perfused rat kidney.

1987 ◽  
Vol 28 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Shosaku NARUMI ◽  
Toshiyuki YASUI ◽  
Mamoru YOSHIZAWA ◽  
Minako KAWAMURA ◽  
Hiromichi SUZUKI ◽  
...  
Keyword(s):  
Renal Function ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Atrial Natriuretic

scholarly journals Regulation of kallikrein and renin release by the isolated perfused rat kidney

1983 ◽  
Vol 24 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Jiro Misumi ◽  
François Alhenc-Gelas ◽  
Michel Marre ◽  
Jeanine Marchetti ◽  
Pierre Corvol ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

The effects of dopamine on renin release in the isolated perfused rat kidney

1979 ◽  
Vol 35 (9) ◽  
pp. 1205-1205 ◽  
Author(s):  
T. Quesada ◽  
L. Garcia-Torres ◽  
F. Alba ◽  
C. Garcia del Rio
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney
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