Effect of allogeneic blood transfusion on solid tumor growth and pulmonary metastases in mice

1992 ◽  
Vol 118 (3) ◽  
pp. 176-180 ◽  
Author(s):  
S. Shirwadkar ◽  
M. A. Blajchman ◽  
B. Frame ◽  
D. P. Singal
Keyword(s):  
Blood Transfusion ◽  
Tumor Growth ◽  
Solid Tumor ◽  
Pulmonary Metastases ◽  
Allogeneic Blood Transfusion ◽  
Allogeneic Blood ◽  
Solid Tumor Growth

scholarly journals Allogeneic blood transfusion-induced enhancement of tumor growth: two animal models showing amelioration by leukodepletion and passive transfer using spleen cells [see comments]

Blood ◽  
1993 ◽  
Vol 81 (7) ◽  
pp. 1880-1882
Author(s):  
MA Blajchman ◽  
L Bardossy ◽  
R Carmen ◽  
A Sastry ◽  
DP Singal
Keyword(s):  
Blood Transfusion ◽  
Tumor Growth ◽  
Inbred Mice ◽  
Allogeneic Blood Transfusion ◽  
Allogeneic Blood ◽  
Nodule Formation ◽  
Blood Transfusions ◽  
Spleen Cells ◽  
Promoting Effect ◽  
Growth Promoting

Allogeneic blood transfusions have been reported to induce immunomodulation in recipients of blood products. While the mechanism(s) of this immunomodulatory effect is unknown, it has been suggested that this effect of allogeneic blood transfusions could adversely affect patients with a malignant disorder. These concerns have been supported by a number of nonrandomized, mainly retrospective, clinical studies which indicate that allogeneic blood transfusions can adversely affect prognosis following the surgical treatment of oncology patients. Recently, we have shown that allogeneic blood transfusions enhance primary tumor growth and increase metastatic pulmonary nodule formation in inbred mice. The tumor growth-promoting activity of allogeneic blood transfusions was studied also using outbred rabbits. In this present study, we demonstrate that the tumor growth-promoting effect of allogeneic blood transfusions is mediated by donor leukocytes and that this effect can be abolished by their removal before transfusion. We show also that the allogeneic blood transfusion tumor growth-promoting effect can be passively transferred to naive animals (both mice and rabbits) using spleen cells from allogeneically transfused animals. In these experiments, numbers of metastatic pulmonary nodules were significantly increased in both mice and rabbits that had received spleen cells from allogeneically transfused animals compared with those that had received spleen cells from syngeneically transfused animals, or from animals that had been transfused with leukodepleted allogeneic blood.

scholarly journals Allogeneic blood transfusion-induced enhancement of tumor growth: two animal models showing amelioration by leukodepletion and passive transfer using spleen cells [see comments]

Blood ◽  
1993 ◽  
Vol 81 (7) ◽  
pp. 1880-1882 ◽  
Author(s):  
MA Blajchman ◽  
L Bardossy ◽  
R Carmen ◽  
A Sastry ◽  
DP Singal
Keyword(s):  
Blood Transfusion ◽  
Tumor Growth ◽  
Inbred Mice ◽  
Allogeneic Blood Transfusion ◽  
Allogeneic Blood ◽  
Nodule Formation ◽  
Blood Transfusions ◽  
Spleen Cells ◽  
Promoting Effect ◽  
Growth Promoting

Abstract Allogeneic blood transfusions have been reported to induce immunomodulation in recipients of blood products. While the mechanism(s) of this immunomodulatory effect is unknown, it has been suggested that this effect of allogeneic blood transfusions could adversely affect patients with a malignant disorder. These concerns have been supported by a number of nonrandomized, mainly retrospective, clinical studies which indicate that allogeneic blood transfusions can adversely affect prognosis following the surgical treatment of oncology patients. Recently, we have shown that allogeneic blood transfusions enhance primary tumor growth and increase metastatic pulmonary nodule formation in inbred mice. The tumor growth-promoting activity of allogeneic blood transfusions was studied also using outbred rabbits. In this present study, we demonstrate that the tumor growth-promoting effect of allogeneic blood transfusions is mediated by donor leukocytes and that this effect can be abolished by their removal before transfusion. We show also that the allogeneic blood transfusion tumor growth-promoting effect can be passively transferred to naive animals (both mice and rabbits) using spleen cells from allogeneically transfused animals. In these experiments, numbers of metastatic pulmonary nodules were significantly increased in both mice and rabbits that had received spleen cells from allogeneically transfused animals compared with those that had received spleen cells from syngeneically transfused animals, or from animals that had been transfused with leukodepleted allogeneic blood.

Modulation of tumor growth by allogeneic blood transfusion

1986 ◽  
Vol 111 (1) ◽  
pp. 50-53 ◽  
Author(s):  
R. L. Marquet ◽  
R. W. F. de Bruin ◽  
R. J. Dallinga ◽  
S. K. Singh ◽  
J. Jeekel
Keyword(s):  
Blood Transfusion ◽  
Tumor Growth ◽  
Allogeneic Blood Transfusion ◽  
Allogeneic Blood

Allogeneic blood transfusion and AIS surgery: how the NSQIP database can improve patient safety

2021 ◽  
Author(s):  
Hady Eltayeby ◽  
Catherine Brown ◽  
Brendan T. Campbell ◽  
Craig Bonanni ◽  
Mark Indelicato ◽  
...  
Keyword(s):  
Patient Safety ◽  
Blood Transfusion ◽  
Improve Patient Safety ◽  
Allogeneic Blood Transfusion ◽  
Allogeneic Blood ◽  
Improve Patient
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