Mammalian cell transformation assays: What role can they play in the identification of carcinogens?

1986 ◽  
Vol 10 (3) ◽  
pp. 205-207
Author(s):  
Raymond W. Tennant
Keyword(s):  
Mammalian Cell ◽  
Cell Transformation

scholarly journals Procaryotic genomic DNA inhibits mammalian cell transformation.

1983 ◽  
Vol 3 (5) ◽  
pp. 956-959 ◽  
Author(s):  
J I Yoder ◽  
A T Ganesan
Keyword(s):  
Thymidine Kinase ◽  
Mammalian Cell ◽  
Genomic Dna ◽  
Cell Transformation ◽  
Phage Dna ◽  
Mouse Cells

Ltk- mouse cells were transformed to thymidine kinase prototrophy in the presence of carrier DNAs isolated from different organisms. Procaryotic genomic and phage DNA was consistently less effective as a carrier than was eucaryotic DNA. Mixing experiments indicate that DNA of procaryotic origin inhibits mammalian cell transformation.

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