Intrahemispheric gradients of brain tissue pressure in patients with brain tumours

1988 ◽  
Vol 93 (3-4) ◽  
pp. 129-132 ◽  
Author(s):  
J. Piek ◽  
P. Plewe ◽  
W. J. Bock
Keyword(s):  
Brain Tissue ◽  
Brain Tumours ◽  
Tissue Pressure

Regional brain tissue pressure gradients created by expanding extradural temporal mass lesion

1997 ◽  
Vol 86 (3) ◽  
pp. 505-510 ◽  
Author(s):  
Christopher E. Wolfla ◽  
Thomas G. Luerssen ◽  
Robin M. Bowman
Keyword(s):  
Intracranial Pressure ◽  
Frontal Lobe ◽  
Brain Tissue ◽  
Temporal Lobe ◽  
Mass Lesion ◽  
Pressure Monitor ◽  
Tissue Pressure ◽  
Content Type ◽  
Regional Brain ◽  
The Right

✓ A porcine model of regional intracranial pressure was used to compare regional brain tissue pressure (RBTP) changes during expansion of an extradural temporal mass lesion. Measurements of RBTP were obtained by placing fiberoptic intraparenchymal pressure monitors in the right and left frontal lobes (RF and LF), right and left temporal lobes (RT and LT), midbrain (MB), and cerebellum (CB). During expansion of the right temporal mass, significant RBTP gradients developed in a reproducible pattern: RT > LF = LT > RF > MB > CB. These gradients appeared early, widened as the volume of the mass increased, and persisted for the entire duration of the experiment. The study indicates that RBTP gradients develop in the presence of an extradural temporal mass lesion. The highest RBTP was recorded in the ipsilateral temporal lobe, whereas the next highest was recorded in the contralateral frontal lobe. The RBTP that was measured in either frontal lobe underestimated the temporal RBTP. These results indicated that if a frontal intraparenchymal pressure monitor is used in a patient with temporal lobe pathology, the monitor should be placed on the contralateral side and a lower threshold for therapy of increased intracranial pressure should be adopted. Furthermore, this study provides further evidence that reliance on a single frontal intraparenchymal pressure monitor may not detect all areas of elevated RBTP.

scholarly journals Determination of SOX9 Gene Expression In Brain Tumours Among East Coast Malaysia Population

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Md Dzali NB ◽  
Wan Taib WR ◽  
Zahary MN ◽  
Abu Bakar NH ◽  
Abd Latif AZ ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Brain Tumour ◽  
Brain Tumours ◽  
East Coast ◽  
Rna Extraction ◽  
Slight Modification ◽  
Low Grade ◽  
Normal Brain ◽  
Sox9 Expression ◽  
Sox9 Gene

Introduction: SOX9, a members of SOX family, plays a significant roles in developmental processes during embryogenesis, including brain tissue. Few studies have shown that SOX9 has been involved in tumourigenesis of several types of cancer including brain tumour. However, such studies are still lacking in the Malaysian population. The aim of this study was to determine SOX9 expression level in several types of brain tumours in East Coast Malaysia. Materials and Methods: Five formalin-fixed pariffin-embedded brain tumour samples of Malay descendants were sectioned by using microtome. RNA extraction was performed with slight modification by adding Trizol during tissue lysis. The RNA was converted to cDNA using reverse transcription technique before SOX9 expression was detected using RT q-PCR assay in brain tumours normalized to non-neoplastic brain tissues. Results: Overall results displayed that SOX9 gene in all samples were up-regulated. SOX9 overexpression was found in both high and low grade glioma (anaplastic and pilocytic astrocytoma respectively). This is consistence with both low grade (benign) and atypical meningioma. Secondary brain tumour also showed up-regulation when compared to normal brain tissue. Conclusion: Up-regulation in SOX9 expression in selected brain tumours in Malay patients revealed its significant roles in brain tumourigenesis. Functional studies should be carried out to observe the SOX9 functions and mechanism whether they should reflect their diverse roles in Malaysia population.

Brain Tissue Pressure in Focal Cerebral Ischemia with and without Reperfusion

1986 ◽  
pp. 566-569 ◽  
Author(s):  
F. Iannotti ◽  
G. P. Schielke ◽  
V. Albanese ◽  
P. Picozzi ◽  
M. Rotondo ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Brain Tissue ◽  
Focal Cerebral Ischemia ◽  
Tissue Pressure

Method for measuring brain tissue pressure

1975 ◽  
Vol 43 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Robert M. Clark ◽  
Norman F. Capra ◽  
James H. Halsey
Keyword(s):  
Blood Pressure ◽  
Brain Tissue ◽  
Systemic Blood Pressure ◽  
Systemic Blood ◽  
Tissue Pressure ◽  
Content Type ◽  
Pressure Changes ◽  
Local Brain

✓ The authors report a method for measuring total local brain tissue pressure (BTP) using a miniature catheter transducer stereotaxically introduced into the white matter of the cat's cerebrum. Quantitative rapid phasic pressure changes were satisfactorily demonstrated. Due to some drift of baseline of the transducers and inability to perform in vivo calibration, reliable long-term quantitative pressure measurements sometimes could not be studied. The BTP from each cerebral hemisphere and the cisternal pressure (CP) were monitored during alterations of pCO2 and systemic blood pressure, and distilled H2O injection prior to and after right middle cerebral artery (MCA) ligation. The catheter transducers functioned well on chronic implantation for up to 6 weeks. Compared to the chronically implanted catheters, acutely implanted catheters responded identically except for drift. The response of intracranial pressure and CP to MCA occlusion, alterations in pCO2, and systemic blood pressure were similar. No BTP gradients appeared in response to MCA ligation, hypercapnia, hypertension, or progressive swelling of the resulting infarction.

scholarly journals Measurement of Brain Tissue Pressure

1978 ◽  
Vol 18pt2 (1) ◽  
pp. 11-20
Author(s):  
MASAHIRO FURUSE ◽  
MICHIAKI HASUO ◽  
HIROJI KUCHIWAKI
Keyword(s):  
Brain Tissue ◽  
Tissue Pressure

scholarly journals Ex Vivo Raman Spectrochemical Analysis Using a Handheld Probe Demonstrates High Predictive Capability of Brain Tumour Status

Biosensors ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 49 ◽  
Author(s):  
Danielle Bury ◽  
Camilo Morais ◽  
Katherine Ashton ◽  
Timothy Dawson ◽  
Francis Martin
Keyword(s):  
Gold Nanoparticles ◽  
Brain Tissue ◽  
Brain Tumour ◽  
Sensitivity And Specificity ◽  
Brain Tumours ◽  
Ex Vivo ◽  
Diagnostic Tools ◽  
Low Grade ◽  
Normal Brain ◽  
Raman Probe

With brain tumour incidence increasing, there is an urgent need for better diagnostic tools. Intraoperatively, brain tumours are diagnosed using a smear preparation reported by a neuropathologist. These have many limitations, including the time taken for the specimen to reach the pathology department and for results to be communicated to the surgeon. There is also a need to assist with resection rates and identifying infiltrative tumour edges intraoperatively to improve clearance. We present a novel study using a handheld Raman probe in conjunction with gold nanoparticles, to detect primary and metastatic brain tumours from fresh brain tissue sent for intraoperative smear diagnosis. Fresh brain tissue samples sent for intraoperative smear diagnosis were tested using the handheld Raman probe after application of gold nanoparticles. Derived Raman spectra were inputted into forward feature extraction algorithms to build a predictive model for sensitivity and specificity of outcome. These results demonstrate an ability to detect primary from metastatic tumours (especially for normal and low grade lesions), in which accuracy, sensitivity and specificity were respectively equal to 98.6%, 94.4% and 99.5% for normal brain tissue; 96.1%, 92.2% and 97.0% for low grade glial tumours; 90.3%, 89.7% and 90.6% for high grade glial tumours; 94.8%, 63.9% and 97.1% for meningiomas; 95.4%, 79.2% and 98.8% for metastases; and 99.6%, 88.9% and 100% for lymphoma, based on smear samples (κ = 0.87). Similar results were observed when compared to the final formalin-fixed paraffin embedded tissue diagnosis (κ = 0.85). Overall, our results have demonstrated the ability of Raman spectroscopy to match results provided by intraoperative smear diagnosis and raise the possibility of use intraoperatively to aid surgeons by providing faster diagnosis. Moving this technology into theatre will allow it to develop further and thus reach its potential in the clinical arena.

Complications of brain tissue pressure monitoring with a fiberoptic device

1998 ◽  
Vol 21 (4) ◽  
pp. 254-259 ◽  
Author(s):  
Ahmet Bekar ◽  
Suna G�ren ◽  
Ender Korfali ◽  
Kaya Aksoy ◽  
Suat Boyaci
Keyword(s):  
Brain Tissue ◽  
Pressure Monitoring ◽  
Tissue Pressure ◽  
Fiberoptic Device

Brain tissue pressure gradients in experimental infarction and space occupying lesions

1974 ◽  
Vol 77 (3-4) ◽  
pp. 198-211 ◽  
Author(s):  
Cornelius A.F Tulleken ◽  
John Stirling Meyer ◽  
Erwin O Ott ◽  
Jacob Abraham ◽  
Ronald F Dodson
Keyword(s):  
Brain Tissue ◽  
Pressure Gradients ◽  
Tissue Pressure
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