The effect of ketanserin on cerebral blood flow and oxygen metabolism in healthy volunteers

1993 ◽  
Vol 125 (1-4) ◽  
pp. 83-85 ◽  
Author(s):  
K. S. Olsen ◽  
P. L. Madsen ◽  
T. B�rme ◽  
J. F. Schmidt
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Oxygen Metabolism

scholarly journals Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis

2020 ◽  
Vol 41 (1) ◽  
pp. 182-193 ◽  
Author(s):  
Kathryn L West ◽  
Dinesh K Sivakolundu ◽  
Mark D Zuppichini ◽  
Monroe P Turner ◽  
Jeffrey S Spence ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Motor Cortex ◽  
Healthy Volunteers ◽  
Primary Motor Cortex ◽  
Motor Impairment ◽  
Oxygen Metabolism ◽  
Button Press

The neural mechanisms underlying motor impairment in multiple sclerosis (MS) remain unknown. Motor cortex dysfunction is implicated in blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies, but the role of neural–vascular coupling underlying BOLD changes remains unknown. We sought to independently measure the physiologic factors (i.e., cerebral blood flow (ΔCBF), cerebral metabolic rate of oxygen (ΔCMRO2), and flow–metabolism coupling (ΔCBF/ΔCMRO2), utilizing dual-echo calibrated fMRI (cfMRI) during a bilateral finger-tapping task. We utilized cfMRI to measure physiologic responses in 17 healthy volunteers and 32 MS patients (MSP) with and without motor impairment during a thumb-button-press task in thumb-related (task-central) and surrounding primary motor cortex (task-surround) regions of interest (ROIs). We observed significant ΔCBF and ΔCMRO2 increases in all MSP compared to healthy volunteers in the task-central ROI and increased flow–metabolism coupling (ΔCBF/ΔCMRO2) in the MSP without motor impairment. In the task-surround ROI, we observed decreases in ΔCBF and ΔCMRO2 in MSP with motor impairment. Additionally, ΔCBF and ΔCMRO2 responses in the task-surround ROI were associated with motor function and white matter damage in MSP. These results suggest an important role for task-surround recruitment in the primary motor cortex to maintain motor dexterity and its dependence on intact white matter microstructure and neural–vascular coupling.

Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers

2017 ◽  
Vol 31 (7) ◽  
pp. 553-562
Author(s):  
Nobuhiro Yada ◽  
Hideo Onishi ◽  
Masahiro Miyai ◽  
Kentarou Ozasa ◽  
Takashi Katsube ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Resolution Recovery

scholarly journals Cerebral blood flow autoregulation in ischemic heart failure

2017 ◽  
Vol 312 (1) ◽  
pp. R108-R113 ◽  
Author(s):  
J. R. Caldas ◽  
R. B. Panerai ◽  
V. J. Haunton ◽  
J. P. Almeida ◽  
G. S. R. Ferreira ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Neurological Complications ◽  
Ischemic Heart ◽  
Step Response ◽  
Ischemic Heart Failure ◽  
Arterial Blood ◽  
End Tidal

Patients with ischemic heart failure (iHF) have a high risk of neurological complications such as cognitive impairment and stroke. We hypothesized that iHF patients have a higher incidence of impaired dynamic cerebral autoregulation (dCA). Adult patients with iHF and healthy volunteers were included. Cerebral blood flow velocity (CBFV, transcranial Doppler, middle cerebral artery), end-tidal CO2 (capnography), and arterial blood pressure (Finometer) were continuously recorded supine for 5 min at rest. Autoregulation index (ARI) was estimated from the CBFV step response derived by transfer function analysis using standard template curves. Fifty-two iHF patients and 54 age-, gender-, and BP-matched healthy volunteers were studied. Echocardiogram ejection fraction was 40 (20–45) % in iHF group. iHF patients compared with control subjects had reduced end-tidal CO2 (34.1 ± 3.7 vs. 38.3 ± 4.0 mmHg, P < 0.001) and lower ARI values (5.1 ± 1.6 vs. 5.9 ± 1.0, P = 0.012). ARI <4, suggestive of impaired CA, was more common in iHF patients (28.8 vs. 7.4%, P = 0.004). These results confirm that iHF patients are more likely to have impaired dCA compared with age-matched controls. The relationship between impaired dCA and neurological complications in iHF patients deserves further investigation.

Changes in SPECT Cerebral Blood Flow Following Japanese Style, Superficial Acupuncture at LI-4 and LI-11 in Healthy Volunteers

2011 ◽  
Vol 17 (4) ◽  
pp. 357-362 ◽  
Author(s):  
Woo-Sang Jung ◽  
Seong-Uk Park ◽  
Jung-Mi Park ◽  
Deog-Yoon Kim ◽  
Il-Ki Hong ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers

Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis

1993 ◽  
Vol 120 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Makoto Tanaka ◽  
Susumu Kondo ◽  
Shunsaku Hirai ◽  
Xiaoyan Sun ◽  
Takayuki Yamagishi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Amyotrophic Lateral Sclerosis ◽  
Cerebral Blood Flow ◽  
Oxygen Metabolism ◽  
Progressive Dementia ◽  
Lateral Sclerosis
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