Germanium-carbon versus germanium-nitrogen double-bond formation in the reactions between germylenes and diazo compounds

1990 ◽  
Vol 1 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Christopher Glidewell
Keyword(s):  
Double Bond ◽  
Bond Formation ◽  
Diazo Compounds ◽  
Nitrogen Double Bond

Alkylative amination of aldehydes via carbon-carbon bond formation based on radical addition to carbon-nitrogen double bond

Tetrahedron ◽  
1999 ◽  
Vol 55 (37) ◽  
pp. 11209-11218 ◽  
Author(s):  
Hideto Miyabe ◽  
Kumiko Yamakawa ◽  
Naoko Yoshioka ◽  
Takeaki Naito
Keyword(s):  
Double Bond ◽  
Bond Formation ◽  
Radical Addition ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Nitrogen Double Bond

Configuration stability at the carbon-nitrogen double bond

1962 ◽  
Vol 3 (26) ◽  
pp. 1269-1274 ◽  
Author(s):  
D.Y. Curtin ◽  
C.G. McCarty
Keyword(s):  
Double Bond ◽  
Nitrogen Double Bond

ChemInform Abstract: Chemistry of Organolanthanoids. Lanthanoid-Mediated C-C Bond Formation and Cleavage and C-C Double Bond Reduction.

ChemInform ◽  
1988 ◽  
Vol 19 (2) ◽  
Author(s):  
Z. HOU ◽  
Y. FUJIWARA ◽  
T. JINTOKU ◽  
N. MINE ◽  
K. YOKOO ◽  
...  
Keyword(s):  
Double Bond ◽  
Bond Formation

Critical Review of Biotransformational Studies on Steroids by Using Culture of Cunninghamella blakesleeana

2021 ◽  
Vol 18 ◽  
Author(s):  
Azizuddin ◽  
Muhammad Iqbal ◽  
Syed Ghulam Musharraf
Keyword(s):  
Double Bond ◽  
Critical Review ◽  
Structural Modification ◽  
Bond Formation ◽  
Environmentally Friendly ◽  
Side Chain ◽  
Synthetic Compounds ◽  
Efficient Approach ◽  
Cunninghamella Blakesleeana ◽  
Different Strains

: For several decades, biotransformational studies on steroidal compounds have gained a lot of attention because it is an efficient approach for the structural modification of complicated natural or synthetic compounds with high regio-, chemo- and stereoselectivity at environmentally friendly conditions. This review summarizes the use of different strains of Cunninghamella blakesleeana for the biotransformation of sixteen steroids 1-16 into a variety of transformed products. The transformed products may be important as a drug or precursor for the production of important pharmaceuticals. The types of reactions performed by C. blakesleeana include hydroxylation, epoxidation, reduction, demethylation, oxidation, glycosidation, double bond formation, side-chain degradation, isomerisation and opening of an isoxazol ring, which would be difficult to produce by traditional synthesis.

scholarly journals Cathodic hydrodimerization of nitroolefins

2015 ◽  
Vol 11 ◽  
pp. 1163-1174 ◽  
Author(s):  
Michael Weßling ◽  
Hans J Schäfer
Keyword(s):  
Double Bond ◽  
Nitro Group ◽  
Bond Formation ◽  
Cathodic Reduction ◽  
High Yield ◽  
Easy Access ◽  
Electrolysis Cell ◽  
Aldehydes And Ketones ◽  
Nef Reaction

Nitroalkenes are easily accessible in high variety by condensation of aldehydes with aliphatic nitroalkanes. They belong to the group of activated alkenes that can be hydrodimerized by cathodic reduction. There are many olefins with different electron withdrawing groups used for cathodic hydrodimerization, but not much is known about the behaviour of the nitro group. Synthetic applications of this group could profit from the easy access to nitroolefins in large variety, the C–C bond formation with the introduction of two nitro groups in a 1,4-distance and the conversions of the nitro group by reduction to oximes and amines, the conversion into aldehydes and ketones via the Nef reaction and base catalyzed condensations at the acidic CH bond. Eight 1-aryl-2-nitro-1-propenes have been electrolyzed in an undivided electrolysis cell to afford 2,5-dinitro-3,4-diaryl hexanes in high yield. The 4-methoxy-, 4-trifluoromethyl-, 2-chloro- and 2,6-difluorophenyl group and furthermore the 2-furyl and 2-pyrrolyl group have been applied. The reaction is chemoselective as only the double bond but not the nitro group undergoes reaction, is regioselective as a ß,ß-coupling with regard to the nitro group and forms preferentially two out of six possible diastereomers as major products.

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