Primary normal-stress coefficient prediction at high shear rates

1988 ◽  
Vol 27 (6) ◽  
pp. 567-574 ◽  
Author(s):  
Chr Friedrich ◽  
L. Heymann
Keyword(s):  
Normal Stress ◽  
High Shear ◽  
Shear Rates ◽  
High Shear Rates ◽  
Stress Coefficient

scholarly journals Evaluating the exit pressure method for measurements of normal stress difference at high shear rates

2020 ◽  
Vol 64 (3) ◽  
pp. 739-750 ◽  
Author(s):  
Dahang Tang ◽  
Flávio H. Marchesini ◽  
Ludwig Cardon ◽  
Dagmar R. D’hooge
Keyword(s):  
Normal Stress ◽  
Normal Stress Difference ◽  
High Shear ◽  
Stress Difference ◽  
Shear Rates ◽  
Pressure Method ◽  
Exit Pressure ◽  
High Shear Rates

Relative Involvement of GPIb/IX-vWF Axis and GPIIb/IIIa in Thrombus Growth at High Shear Rates in the Guinea Pig

1997 ◽  
Vol 17 (5) ◽  
pp. 919-924 ◽  
Author(s):  
Patrick André ◽  
Patricia Hainaud ◽  
Claire Bal dit Sollier ◽  
Leonard I. Garfinkel ◽  
Jacques P. Caen ◽  
...  
Keyword(s):  
Guinea Pig ◽  
High Shear ◽  
Shear Rates ◽  
High Shear Rates

scholarly journals Microfluidic rheology: A new approach to measure viscosity of ceramic suspensions at extremely high shear rates

Open Ceramics ◽  
2021 ◽  
Vol 5 ◽  
pp. 100052
Author(s):  
V. Carnicer ◽  
C. Alcázar ◽  
M.J. Orts ◽  
E. Sánchez ◽  
R. Moreno
Keyword(s):  
High Shear ◽  
New Approach ◽  
Shear Rates ◽  
High Shear Rates ◽  
Ceramic Suspensions

Flow curves of mixtures of acrylonitrile–styrene copolymers with different molecular weights at extremely high shear rates (abstract)

1991 ◽  
Vol 35 (4) ◽  
pp. 706-706
Author(s):  
Hideroh Takahashi ◽  
Yoshinori Inoue ◽  
Satoru Yamamoto ◽  
Osami Kamigaito
Keyword(s):  
High Shear ◽  
Flow Curves ◽  
Shear Rates ◽  
Molecular Weights ◽  
Styrene Copolymers ◽  
High Shear Rates

Comparison of antithrombotic efficacy between edoxaban, a direct factor Xa inhibitor, and fondaparinux, an indirect factor Xa inhibitor under low and high shear rates

2011 ◽  
Vol 106 (12) ◽  
pp. 1062-1068 ◽  
Author(s):  
Naoki Tsuji ◽  
Yuko Honda ◽  
Chikako Kamisato ◽  
Yoshiyuki Morishima ◽  
Toshiro Shibano ◽  
...  
Keyword(s):  
Shear Rate ◽  
Arterial Thrombosis ◽  
Factor Xa ◽  
High Shear ◽  
Shear Rates ◽  
Thrombosis Model ◽  
Perfusion Chamber ◽  
High Shear Rates ◽  
Antithrombotic Effects ◽  
Antithrombotic Efficacy

SummaryEdoxaban is an oral, direct factor Xa (FXa) inhibitor under late-phase clinical development. This study compared the antithrombotic efficacy of edoxaban with that of an indirect FXa inhibitor, fondaparinux, in in vivo venous and arterial thrombosis models and in ex vivo perfusion chamber thrombosis model under low and high shear rates in rats. Venous and arterial thrombi were induced by platinum wire insertion into the inferior vena cava and by application of FeCl3 to the carotid artery, respectively. The perfusion chamber thrombus was formed by blood perfusion into a collagen-coated capillary at 150 s-1 (low shear rate) and 1,600 s-1 (high shear rate). Effective doses of edoxaban that reduced thrombus formation by 50% (ED50) in venous and arterial thrombosis models were 0.076 and 0.093 mg/kg/h, respectively. In contrast, ED50 of fondaparinux in the arterial thrombosis model (>10 mg/kg/h) was markedly higher compared to ED50 in the venous thrombosis model (0.021 mg/kg/h). In the perfusion chamber thrombosis model, the ratio of ED50 under high shear rate (1.13 mg/kg/h) to that under low shear rate (0.63 mg/kg/h) for edoxaban was 1.9, whereas that for fondaparinux was more than 66. While the efficacy of fondaparinux markedly decreased in arterial thrombosis and in a high-shear state, edoxaban exerted consistent antithrombotic effects regardless of flow conditions. These results suggest that shear rate is a key factor in different antithrombotic effects between edoxaban and fondaparinux.

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