Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats

1993 ◽  
Vol 53 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Fumiyasu Sato ◽  
Yasuyoshi Ouchi ◽  
Akihiro Masuyama ◽  
Tetsuro Nakamura ◽  
Takayuki Hosoi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Tissue ◽  
Interleukin 1 ◽  
Insulin Like Growth Factor ◽  
Estrogen Replacement ◽  
Factor I ◽  
Growth Factor I

Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue

2009 ◽  
Vol 8 (12) ◽  
pp. 1475-1481 ◽  
Author(s):  
Peter Lakatos ◽  
Matthew D. Caplice ◽  
Vikram Khanna ◽  
Paula H. Stern
Keyword(s):  
Growth Factor ◽  
Thyroid Hormones ◽  
Bone Tissue ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Rat Bone

Down-regulation of Leydig cell insulin-like growth factor-I gene expression by interleukin-1.

Endocrinology ◽  
1992 ◽  
Vol 130 (3) ◽  
pp. 1217-1224
Author(s):  
T Lin ◽  
D Wang ◽  
M L Nagpal ◽  
W Chang ◽  
J H Calkins
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Leydig Cell ◽  
Interleukin 1 ◽  
Insulin Like Growth Factor ◽  
Down Regulation ◽  
Factor I ◽  
Growth Factor I ◽  
I Gene

scholarly journals Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-I

1993 ◽  
Vol 290 (3) ◽  
pp. 901-905 ◽  
Author(s):  
D R Poyner ◽  
M R Hanley ◽  
T R Jackson ◽  
P T Hawkins
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Protein Tyrosine Kinase ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Neuronal Cell ◽  
Insulin Like Growth Factor ◽  
Intact Cells ◽  
Factor I ◽  
Growth Factor I

The activation of phosphoinositide 3-hydroxykinase (P13K) is currently believed to represent the critical regulatory event which leads to the production of a novel intracellular signal. We have examined the control of this pathway by a number of cell-surface receptors in NG115-401L-C3 neuronal cells. Insulin-like growth factor-I stimulated the accumulation of 3-phosphorylated inositol lipids in intact cells and the appearance of P13K in antiphosphotyrosine-antibody-directed immunoprecipitates prepared from lysed cells, suggesting that P13K had been activated by a mechanism involving a protein tyrosine kinase. In contrast, P13K in these cells was not regulated by a variety of G-protein-coupled receptors, nerve growth factor acting via a low affinity receptor, or receptors for transforming growth factor-beta and interleukin-1. The receptor-specificity of P13K activation in these cells places significant constraints on the possible physiological function(s) of this pathway.

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